Clay-based nanocomposite hydrogel with attractive mechanical properties and sustained bioactive ion release for bone defect repair

Zhai, Xinyun; Ruan, Changshun; Shen, Jie; Zheng, Chuping; Zhao, Xiaoli; Pan, Haobo; Lu, William W.

doi:10.1039/d1tb00184a

Cited by 26 publications

(29 citation statements)

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“…MBGNs acting as cell signaling cues can deliver biologically active ions such as calcium and silicon to form an induced microenvironment which stimulates osteogenic differentiation, of importance for bone regeneration. [65][66][67][68] The use of bioactive ions as biochemical cues has attracted great interest in recent years to improve bone tissue formation by using bioactive additives such as hydroxyapatite (HA), [13,69] tricalcium phosphate (TCP), [70,71] calcium phosphate, [72] and bioactive glasses. [73] Because of the natural similarity to the inorganic component in bones, those Ca-containing fillers are highly applied toward activating the extracellular-signal-regulated kinase (ERK1/2), and thus to upregulate osteogenic differentiation.…”

Section: Discussionmentioning

confidence: 99%

3D Bioprinting of Multifunctional Dynamic Nanocomposite Bioinks Incorporating Cu‐Doped Mesoporous Bioactive Glass Nanoparticles for Bone Tissue Engineering

Zhu

Monavari

Zheng

et al. 2022

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Bioprinting has seen significant progress in recent years for the fabrication of bionic tissues with high complexity. However, it remains challenging to develop cell‐laden bioinks exhibiting superior physiochemical properties and bio‐functionality. In this study, a multifunctional nanocomposite bioink is developed based on amine‐functionalized copper (Cu)‐doped mesoporous bioactive glass nanoparticles (ACuMBGNs) and a hydrogel formulation relying on dynamic covalent chemistry composed of alginate dialdehyde (oxidized alginate) and gelatin, with favorable rheological properties, improved shape fidelity, and structural stability for extrusion‐based bioprinting. The reversible dynamic microenvironment in combination with the impact of cell‐adhesive ligands introduced by aminated particles enables the rapid spreading (within 3 days) and high survival (>90%) of embedded human osteosarcoma cells and immortalized mouse bone marrow‐derived stroma cells. Osteogenic differentiation of primary mouse bone marrow stromal stem cells (BMSCs) and angiogenesis are promoted in the bioprinted alginate dialdehyde‐gelatin (ADA‐GEL or AG)‐ACuMBGN scaffolds without additional growth factors in vitro, which is likely due to ion stimulation from the incorporated nanoparticles and possibly due to cell mechanosensing in the dynamic matrix. In conclusion, it is envisioned that these nanocomposite bioinks can serve as promising platforms for bioprinting complex 3D matrix environments providing superior physiochemical and biological performance for bone tissue engineering.

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Section: Discussionmentioning

confidence: 99%

3D Bioprinting of Multifunctional Dynamic Nanocomposite Bioinks Incorporating Cu‐Doped Mesoporous Bioactive Glass Nanoparticles for Bone Tissue Engineering

Zhu

Monavari

Zheng

et al. 2022

Small

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“…Mineral of the bone matrix is commonly used to reflect the formation of now bone tissue by sequential fluorescent labeling. 73,74 Fluorescent pigments can bind to calcium ions of new bone and merge with the mineralized area of new bone. And the bone newly formed at different time points can be distinguished from different colors of the fluorochrome.…”

Section: Fluorescence Of Newly Formed Bonementioning

confidence: 99%

A conductive photothermal non-swelling nanocomposite hydrogel patch accelerating bone defect repair

Zhou

et al. 2022

Biomater. Sci.

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“…5 The SI in H 2 O was calculated as 45.8% ± 2.7 higher than previously reported values for films containing Priamine 1074. 18 Since Priamine 1074 is derived from fatty acids, it provides hydrophobicity to the films in which it is present, but in this case, ACMO is water-soluble, 19,20 so the final photocurable thermosets show a water resistance balance between their hydrophobic and hydrophilic components.…”

Section: Photocurable Thermosets and Degradation Studymentioning

confidence: 99%

Bio‐based and hydrolytically degradable hydroxyurethane acrylates as photocurable thermosets

Younes

Marić

2021

J of Applied Polymer Sci

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This study focuses on the synthesis of bio-based and hydrolytically degradable photocurable thermosets made from hydroxyurethane acrylates (HUA). The hydroxyurethanes (HUs) are prepared from the reaction between ethylene carbonate and a bio-based diamine, Priamine 1074. Subsequently, the HU initiates the ring opening polymerization of ε-caprolactone (CL), resulting in telechelic groups of 5 CL units at both ends of the HU. The resulting HU-CL 5 is finally acrylated to prepare the degradable HUA (HU-CL 5 -A) with transformations confirmed following each step via proton nuclear magnetic resonance ( 1 H-NMR) and Fourier-transform infrared (FTIR) spectroscopies. HU-CL 5 -A is photocured with 4-acryloylmorpholine (ACMO) as a photosensitive reactive diluent. The photocurable thermosets exhibit slight water swelling (swelling index of 46%), as Priamine 1074 and ACMO are hydrophobic and hydrophilic, respectively, leading to the slow and partial degradation of the films in water at 85 C for 14 days. The cleavage of the CL units from the film networks is proven via 1 H-NMR and FTIR, which demonstrates the main objective of this study in synthesizing photocurable and degradable HUA resins.

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Clay-based nanocomposite hydrogel with attractive mechanical properties and sustained bioactive ion release for bone defect repair

Abstract: Although clay-based nanocomposite hydrogels have been widely explored, the instability of them in hot water and saline solution inhibit their applications in biomedical engineering, and the exploration of clay-based nanocomposite...

Cited by 26 publications

References 50 publications

3D Bioprinting of Multifunctional Dynamic Nanocomposite Bioinks Incorporating Cu‐Doped Mesoporous Bioactive Glass Nanoparticles for Bone Tissue Engineering

3D Bioprinting of Multifunctional Dynamic Nanocomposite Bioinks Incorporating Cu‐Doped Mesoporous Bioactive Glass Nanoparticles for Bone Tissue Engineering

A conductive photothermal non-swelling nanocomposite hydrogel patch accelerating bone defect repair

Bio‐based and hydrolytically degradable hydroxyurethane acrylates as photocurable thermosets

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