Clays as Biomaterials in Controlled Drug Release: A Scientific and Technological Short Review

Abstract

fields that encompass the applications of clays are mainly in civil engineering, paper industry, effluent treatment, photocatalysis, tissue engineering, cosmetics, controlled drug release and others. These materials can be used in manipulations for drug encapsulation both for dermatological application and for oral administration, thus being important material to be exploited in various technological processes, specifically in the pharmaceutical industry [2,[4][5][6][7][8][9][10][11][12][13][14][15]. The objective of this works a bibliographical and technological prospection regarding clays and clay minerals, including their characteristics and modifications, with emphasis on their use as biomaterials, controlled release of drugs.

Magnesium aminoclays as plasmid delivery agents for non-competent Escherichia coli JM109 transformation

“…Sepiolite is a more robust transformation material with more reports in the literature than arginine-glucose functionalized hydroxyapatite nanoparticles and has a 5.9 times higher transformation efficiency than Mg aminoclays using the same host and plasmid (Mendes et al, 2015). However, Mg aminoclays have a higher potential than sepiolite for acquiring enhanced properties that can become a complement to transformation of microorganisms as it has been demonstrated in their use as biosensors (Mann, 2009;Mousty, 2010;Song et al, 2018) or drug delivery nanocarriers (Patil et al, 2005;Patil and Mann, 2008;Chaturbedy et al, 2010;Silva Filho, 2019), making aminoclay-based materials more promising for future implementations of DNA delivery agents since these additional properties can potentially be exploited synergistically with transformation during interaction with cells.…”

Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release

“…Different materials for controlled release are reported in the literature, which have in common the use of phyllosilicates, which is justified because these materials are abundant in nature, are low cost, non-toxic, and have the ability to adsorb ions and/or molecules in their interlamellar space [10,11]. In addition, there is the potential diversity of their use, which is due to the ease with which these materials are modified [12,13,14,15].…”