Clear cell adenocarcinoma of the urinary bladder

Köşem, Mustafa; Sengül, Erdal

doi:10.1080/00365590510007630

Cited by 19 publications

(18 citation statements)

References 6 publications

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“…In general, it is more malignant than common urothelial carcinoma, but more cases and longer follow-up periods are required to elucidate these points. Lymph nodes and bone seem to be the most common metastatic sites for this disease [6,15]. In the current case, the patient was found to have multiple cervical lymphadenectasis and suspected lymphadenectasis around right iliac vessels and inguinal regions after the initial treatment.…”

Section: Discussionmentioning

confidence: 65%

“…Other common locations included trigone, lateral wall and urethra. Unlike urothelial carcinoma, most clear cell adenocarcinomas of bladder were large, solitary masses forming papillary or sessile structures [15]. …”

Section: Discussionmentioning

confidence: 99%

“…No effect of radiotherapy was observed because two cases died with disease in 8 months and 1 year, the other two alive with no evidence of disease in 18 months and 2 years [5-7]. Some patients underwent chemotherapy (including cisplatin, doxorubicin or cyclophosphamide) and/or radiotherapy (40-60 Gy total) as the adjunvant treatment, but with uncertain effects [5,6,15]. …”

Section: Discussionmentioning

confidence: 99%

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Primary clear cell adenocarcinoma of the bladder with recurrence: a case report and literature review

Jiang

et al. 2012

World J Surg Onc

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Clear cell carcinoma of the bladder is a rare tumor of the bladder. There are few reports available on this rare disease, and no cases with recurrence were reported. Here we present a case of 68-year-old woman with primary clear cell carcinoma of the bladder, who underwent repeat TUR-BT and tumor recurrence. We also reviewed the previous treatments and prognoses in previous case reports and evaluate the proper treatment for this disease. Once the diagnosis is determined, the radical surgery should be recommended. The recurrence is not prevented based on post-TUR intravesical therapy.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary clear cell adenocarcinoma of the bladder with recurrence: a case report and literature review

Jiang

et al. 2012

World J Surg Onc

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“…Several hypotheses include derivation from a Müllerian origin, derivation from a urothelial origin due to shared genetic alterations and potentially a non‐Müllerian origin . In contrast to other non‐urothelial bladder carcinomas, there is a female predominance in this category of tumours …”

Section: Tumours Of Müllerian Typementioning

confidence: 99%

“…The major subtypes within this category include clear cell adenocarcinoma and endometrioid adenocarcinoma. At gross examination, clear cell adenocarcinoma occurs most commonly at the bladder neck and appears as a large, solitary mass that is papillary or sessile . The origin is often within the submucosal layers of the bladder, including the lamina propria and muscularis propria.…”

Section: Tumours Of Müllerian Typementioning

confidence: 99%

Non‐urothelial carcinomas of the bladder

2018

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Non‐urothelial carcinomas involving the bladder are uncommon and often diagnostically challenging. These carcinomas may show squamous, adenocarcinomatous or neuroendocrine features, with immunohistochemical stains aiding the diagnosis in only a subset of cases. The clinical history in non‐urothelial bladder carcinomas is important, given that the differential diagnosis often includes secondary involvement of the bladder by direct extension or metastasis from carcinomas at other sites. This paper will review non‐urothelial carcinomas in each of these three morphological categories, emphasising recent changes in diagnostic grouping and challenges in the histopathological diagnosis. Review of bladder cancers with squamous morphology will include discussion of conventional squamous cell carcinoma and verrucous carcinoma and their distinction from urothelial carcinoma with extensive squamous differentiation. Bladder carcinomas with adenocarcinomatous change will include primary bladder adenocarcinoma, urachal adenocarcinoma and tumours of Müllerian type. Finally, neuroendocrine neoplasms of the bladder, including well‐differentiated neuroendocrine tumour and neuroendocrine carcinomas, will be discussed. Associated surface findings, risk factors and prognostic features will be described.

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Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems

Alexiev

Tavora

2013

Virchows Arch

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Clear cell adenocarcinoma (CCAC) of the urethra is a rare neoplasm, morphologically identical to its homologue arising in the female genital tract. The histogenesis of this neoplasm is uncertain. We present clinical, histopathologic, and immunohistochemical findings of four CCAC of the urethra and discuss the histogenesis and difficulties in diagnosis and differential diagnosis. CCAC of the urethra occurred in females (4/4). Two neoplasms were identified in urethral diverticulum; one of the two cases, in close proximity to a nephrogenic adenoma. CCAC exhibited tubulocystic, papillary, and diffuse/solid growth patterns. The neoplastic cells were cuboidal or columnar with eosinophilic or clear cytoplasm, and nuclear pleomorphism of at least moderate degree. Hobnail features and tumor necrosis were also observed. CCAC expressed p53 (4/4), AMACR (3/4), vimentin (3/4), PAX8 (2/4), CK7 (2/4), cytokeratin 34betaE12 (2/4), RCC (1/4), and CK20 (1/4) and were negative for PSA, WT1, ER, CA 125, uroplakin III, p16, and p63. The immunohistochemical profile supports a possible renal tubular cell differentiation/mesonephric origin for some urethral CCAC. Nephrogenic adenoma and metastatic clear cell carcinoma are the most important differential diagnostic considerations. Multicenter studies on more cases may improve our understanding of this malignancy.

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Clear cell adenocarcinoma of the urinary bladder

Cited by 19 publications

References 6 publications

Primary clear cell adenocarcinoma of the bladder with recurrence: a case report and literature review

Primary clear cell adenocarcinoma of the bladder with recurrence: a case report and literature review

Non‐urothelial carcinomas of the bladder

Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems

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