Primary clear cell adenocarcinoma of the bladder with recurrence: a case report and literature review

Lu, Junyan; Xu, Zhihui; Jiang, Fengjing; Wang, Yan; Hou, Yuchuan; Wang, Handong; Chen, Qihui

doi:10.1186/1477-7819-10-33

Cited by 16 publications

(34 citation statements)

References 18 publications

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“…In bladder cancer, which is the 9 th most common cancer diagnosis worldwide [20], the expression of decorin has previously been shown to be decreased [21]–[24]. As decorin acts as a natural antagonist for IGF-IR in tumours, its decreased expression may contribute to increased IGF-IR activity, thus leading to the progression of IGF-IR-dependent cancers through enhanced cellular motility and invasion [23]–[24].…”

Section: Introductionmentioning

confidence: 99%

Lack of Decorin Expression by Human Bladder Cancer Cells Offers New Tools in the Therapy of Urothelial Malignancies

et al. 2013

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Decorin, a multifunctional small leucine-rich extracellular matrix proteoglycan, has been shown to possess potent antitumour activity. However, there is some uncertainty whether different cancer cells express decorin in addition to non-malignant stromal cells. In this study we clarified decorin expression by human bladder cancer cells both in vivo and in vitro. In addition, the effect of adenovirus-mediated decorin expression on human bladder cancer cells in vitro was examined. We first demonstrated using the publicly available GeneSapiens databank that decorin gene expression is present in both normal and malignant human bladder tissues. However, when we applied in situ hybridization with digoxigenin-labeled RNA probes for decorin on human bladder carcinoma tissue samples derived from a large radical cystectomy patient cohort (n = 199), we unambiguously demonstrated that invasive and non-invasive bladder carcinoma cells completely lack decorin mRNA. The cancer cells were also negative for decorin immunoreactivity. Instead, decorin expression was localized solely to original non-malignant stromal areas of bladder tissue. In accordance with the aforementioned results, human bladder cancer cells in vitro were also negative for decorin expression as shown by RT-qPCR analyses. The lack of decorin expression by bladder cancer cells was shown not to be due to the methylation of the proximal promoter region of the decorin gene. When bladder cancer cells were transfected with a decorin adenoviral vector, their proliferation was significantly decreased. In conclusion, we have shown that human bladder cancer cells are totally devoid of decorin expression. We have also shown that adenovirus-mediated decorin gene transduction of human bladder cancer cell lines markedly inhibits their proliferation. Thus, decorin gene delivery offers new potential therapeutic tools in urothelial malignancies.

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Section: Introductionmentioning

confidence: 99%

Lack of Decorin Expression by Human Bladder Cancer Cells Offers New Tools in the Therapy of Urothelial Malignancies

et al. 2013

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“…Clear cell adenocarcinoma of the urinary bladder is one of the rarest histological variants of bladder cancer, and predominantly affects women 7. The exact embryological root remains controversial, with competing theories proposing urothelial versus Müllerian origins 8 9.…”

Section: Discussionmentioning

confidence: 99%

Clear cell adenocarcinoma of the bladder with intravesical cervical invasion

et al. 2015

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“…Since there are no distinguishing symptoms of CCA, diagnosis is based on histopathological identification of these characteristics. Due to its rarity, information on the characteristics and prognosis of CCA have been limited to case reports, with less than 50 cases reported to date [19][20][21]. The largest existing literature review was performed by Lu et al, consisting of 38 case reports [21].…”

Section: Introductionmentioning

confidence: 99%

“…Due to its rarity, information on the characteristics and prognosis of CCA have been limited to case reports, with less than 50 cases reported to date [19][20][21]. The largest existing literature review was performed by Lu et al, consisting of 38 case reports [21]. The review supported surgical resection as initial treatment for CCA and noted a possible increase in metastasis risk compared to urothelial carcinomas.…”

Section: Introductionmentioning

confidence: 99%

“…The review supported surgical resection as initial treatment for CCA and noted a possible increase in metastasis risk compared to urothelial carcinomas. However, the study determined that the prognosis of CCA was unclear as longer follow up periods were needed to more accurately assess survival characteristics [21]. No incidence and mortality data have been reported yet.…”

Section: Introductionmentioning

confidence: 99%

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Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis

Zhou

Kinslow

Wang

et al. 2020

JCM

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Clear cell adenocarcinoma (CCA) is a rare variant of urinary bladder carcinoma with a glycogen-rich phenotype and unknown prognosis. Using the National Cancer Institute’s surveillance, epidemiology, and end results (SEER) program database, we documented recent trends in incidence, mortality, demographical characteristics, and survival on this rare subtype of urinary bladder cancer. The overall age-adjusted incidence and mortality of CCA was 0.087 (95% confidence interval (CI): 0.069–0.107) and 0.064 (95% CI: 0.049–0.081) respectively per million population. In comparison to non-CCAs, CCAs were more commonly associated with younger age (<60 years old, p = 0.005), female (p < 0.001), black ethnicity (p = 0.001), grade III (p < 0.001), and higher AJCC 6th staging (p < 0.001). In addition, CCA patients more frequently received complete cystectomy (p < 0.001) and beam radiation (p < 0.001) than non-CCA patients. Our study showed a poorer prognosis of CCAs compared to all other carcinomas of the urinary bladder (p < 0.001), accounted for by higher tumor staging of CCA cases. This study adds to the growing evidence that glycogen-rich cancers may have unique characteristics affecting tumor aggressiveness and patient prognosis. Additional mechanistic studies are needed to assess whether it’s the excess glycogen that contributes to the higher stage at diagnosis.

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Primary clear cell adenocarcinoma of the bladder with recurrence: a case report and literature review

Cited by 16 publications

References 18 publications

Lack of Decorin Expression by Human Bladder Cancer Cells Offers New Tools in the Therapy of Urothelial Malignancies

Lack of Decorin Expression by Human Bladder Cancer Cells Offers New Tools in the Therapy of Urothelial Malignancies

Clear cell adenocarcinoma of the bladder with intravesical cervical invasion

Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis

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