Clear cell chondrosarcoma mimicking chondroblastoma in a skeletally immature patient

Cannon, Christopher P.; Nelson, Scott D.; Seeger, Leanne L.; Eċkardt, Jeffrey J.

doi:10.1007/s00256-002-0519-7

Cited by 21 publications

(4 citation statements)

References 12 publications

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“…The differential diagnosis of chondroblastoma arises especially in adults with clear cell chondrosarcoma, with a much more severe prognosis. The radiographic, CT and MRI aspects of these two lesions can be strictly identical and only histological analysis can distinguish them [4,5]. And this is the case with our patient.…”

Section: Discussionsupporting

confidence: 65%

Primary aggressive chondroblastoma of the tibia

et al. 2020

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Chondroblastoma is a primary bone tumor in children, adolescents and young adults, which accounts for 1% of all bone tumors. Epiphyseal or epiphysometaphyseal localization, this lesion usually develops from secondary ossification centers close to the knee, shoulder and hip. Although chondroblastoma is a nonaggressive benign tumor, it can very rarely show a locally aggressive character or a malignant transformation or even metastases. We describe a histologically proven case of an aggressive, primary chondroblastoma of the tibia invading soft tissue in a 22-year-old girl.

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Section: Discussionsupporting

confidence: 65%

Primary aggressive chondroblastoma of the tibia

et al. 2020

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“…[6]200016N/AN/AN/AN/A–––––Cannon et al. [49]20021N/ANED24R00–0––Memis et al. [50]20022N/AN/AN/A2 × R00–0––Itälä et al.…”

Section: Resultsmentioning

confidence: 99%

Clear cell chondrosarcoma is an underestimated tumor: Report of 7 cases and meta-analysis of the literature

Klein¹,

Tauscher²,

Birkenmaier³

et al. 2019

Journal of Bone Oncology

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IntroductionClear cell chondrosarcoma (CCC) is a rare subtype of chondrosarcoma and it is commonly considered a low-grade tumor and less aggressive than atypical cartilaginous tumor (grade 1 central chondrosarcoma). However, the experience even of musculoskeletal tumor centres with this rare entity is limited. The aim of this study is to analyse our own treatment results and those of the literature regarding the therapy and outcome of this lesion.Material and Methods7 cases of CCC have been treated in our department between 2003 and 2015. Their follow-up data were collected retrospectively. 187 literature cases with histopathological and clinical characteristics were retrieved by means of a PubMed search with the key word “clear cell chondrosarcoma”. The data pertaining to treatment and follow up were extracted. We analysed the survival of patient and the risk factors for local recurrence (LR) as well as metastatic disease (MD).ResultsThe mean age at the time of diagnosis was 40 years. Two thirds of the patients were male. The mean follow-up time was 109 months. To our surprise, there was a high rate of LR (30%) and of MD (20%) when compared to low-grade conventional chondrosarcomas. 15% of LR and 20% of metastatic disease were observed after more than 10 years follow-up. Uncommon locations of MD such as in the spine is a unique observation in chondrosarcomas and underlines the high aggressiveness of this tumor. 10-year overall survival was almost 80%, 10-years disease free survival 60%. Positive margins (p = 0.038) and metastases (p = 0.006) impaired the overall survival significantly. The rate of local recurrence was significantly dependent on resection margin (p < 0.001); however there was no correlation with the grade of differentiation of the tumor. The development of MD was affected by local recurrence (p = 0.006), but we could not detect a significant association with margin status (p = 0.184).ConclusionsA wide resection is the advocated treatment option. Long term follow-up for at least 10 years is necessary in order to not overlook late LR or MD. This work demonstrates for the first time the apparent aggressiveness of the CCC.

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“…10 CCCS affects males more commonly than females and has been reported in individuals aged 11 to 74 years, but is typically discovered in the third and fourth decades of life. 1-3,7,10-12 The tumor frequently arises at the epimetaphyseal region of the long bones with a predilection for the femoral or humeral head, but has been found to originate at a variety of locations including spine, ribs, and thyroid cartilage. 2,10,13,14…”

Section: Discussionmentioning

confidence: 99%

Clear Cell Chondrosarcoma With Chondroblastoma-Like Features: A Case for Team Diagnosis

et al. 2018

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Clear cell chondrosarcoma (CCCS) is a rare variant of conventional chondrosarcoma with low-grade malignant features that may be confused radiographically and histologically with chondroblastoma. We report a case of a 50-year-old female who presented with 6 months of left hip pain. Initial radiographs demonstrated an osteolytic lesion with adjacent area of sclerosis in the proximal left femur. Magnetic resonance imaging demonstrated a marrow-infiltrative lesion with periosteal reaction and thickened enhancing periosteum. Biopsy of the sclerotic area demonstrated chondroblastoma-like findings, whereas biopsy of the lytic area showed features suggestive of CCCS. The patient eventually underwent en bloc resection and reconstruction with a proximal femoral megaprosthesis. The final diagnosis was CCCS. We present this unusual case with review of the radiographic and histologic features of CCCS with attention to its ability to mimic chondroblastomas. This case highlights the importance of sampling radiographically heterogeneous areas within a bone lesion to facilitate accurate diagnosis and appropriate management.

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Clear cell chondrosarcoma mimicking chondroblastoma in a skeletally immature patient

Cited by 21 publications

References 12 publications

Primary aggressive chondroblastoma of the tibia

Primary aggressive chondroblastoma of the tibia

Clear cell chondrosarcoma is an underestimated tumor: Report of 7 cases and meta-analysis of the literature

Clear Cell Chondrosarcoma With Chondroblastoma-Like Features: A Case for Team Diagnosis

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