Clear-cell hidradenoma.Report of three cases with widespread metastases

Keasbey, Louisa E.; Hadley, G.

doi:10.1002/1097-0142(195409)7:5<934::aid-cncr2820070519>3.0.co;2-5

Cited by 164 publications

(87 citation statements)

References 13 publications

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“…Berg and McDivitt 3 reported 17 hidradenocarcinomas in their series of 102 sweat gland carcinomas, which is the largest series to date. Some of these cases of malignant hidradenomas have been reported as malignant clear cell myoepithelioma, malignant acrospiroma, 7 clear cell hidradenocarcinoma, 4,8 and clear cell eccrine carcinoma. 1,9 Despite the small number of cases and limited follow-up available, an aggressive clinical course characterized by repeated local recurrences and systemic metastasis was often documented.…”

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confidence: 99%

Atypical and malignant hidradenomas: a histological and immunohistochemical study

et al. 2009

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The histological features of atypical hidradenoma are worrisome for increased risk of recurrence and possible malignant potential; however, earlier studies with immunohistochemistry or patient follow-up have not been reported. In addition, immunohistochemical analysis of hidradenocarcinoma exists in the literature mainly as case reports and as a single series of six cases. We compare the histological features and Ki-67, phosphorylated histone H3, epidermal growth factor receptor, and Her2/neu expression profiles of 15 atypical and 15 malignant hidradenomas with those of benign hidradenoma and metastasizing adnexal carcinomas. Infiltrative growth pattern, deep extension, necrosis, nuclear pleomorphism, and Z4 mitoses per 10 high-power fields are specific features of hidradenocarcinomas. Significant difference in mean Ki-67% was observed between benign and malignant hidradenomas (Po0.001), benign and metastasizing adnexal carcinomas (0.002), atypical and malignant hidradenomas (Po0.001), and between atypical hidradenomas and metastasizing adnexal carcinomas (0.002). Significant difference in mean phosphorylated histone H3% was observed between benign and malignant hidradenomas (Po0.001), benign and metastasizing adnexal carcinomas (0.003), atypical and malignant hidradenomas (Po0.001), and between atypical hidradenomas and metastasizing adnexal carcinomas (Po0.001). Mean epidermal growth factor receptor total score was significantly different in benign and atypical hidradenoma when compared with that in metastasizing adnexal carcinoma (P ¼ 0.014 and 0.019, respectively). Equivocal or 2 þ Her2/neu positivity was observed in one hidradenocarcinoma and in two metastasizing adnexal carcinomas. Receiver operating characteristic curve analysis for Ki-67 and phosphorylated histone H3% positivity reveals statistically significant criterion values of 411.425 and 40.7, respectively, for distinguishing malignant hidradenomas from atypical hidradenomas. Despite the presence of some worrisome histological features, the significantly different immunoprofile from the malignant counterpart suggests that atypical hidradenomas are likely to recur but are unlikely to metastasize. A tumor with Ki-67411% and/or phosphorylated histone H340.7% would likely be a malignant rather than an atypical hidradenoma. The infrequent Her2/neu overexpression in hidradenocarcinoma suggests its limited therapeutic role.

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confidence: 99%

Atypical and malignant hidradenomas: a histological and immunohistochemical study

et al. 2009

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“…The malignant hidradenoma is radio-resistant. Overall survival is 15 to 45 months and the progression without recurrence at 5 years is evaluated at 30% [16,17]. The determination of the carcinoembryonic antigen (ACE) is used to detect local recurrent sub-clinical [8].…”

Section: Discussionmentioning

confidence: 99%

Giant Hidradenoma of Limbs: A Report of Two Pediatric Cases

Jlalia¹,

Bahroun²,

Kamoun³

et al. 2017

J Orthop Oncol

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Hidradenoma is a rare benign tumor that develops of the eccrine sweat glands. We report here two cases of benign giant hidradenoma with a clear cell variant in one case and nodular in the other. The tumor was localized on the forearm in a patient aged 6 years and in the foot in a 14-year-old child. An excisional biopsy was performed in both patients. Evolution was marked by a good outcome without recurrence. We try through this paper to review an uncommon tumor which his eccrine origin is controversial and which biological behavior was badly known.

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“…4 Hidradenocarcinoma is a rare aggressive malignant tumour of the eccrine cutaneous sweat glands. 2 Hidradenocarcinoma accounts for approximately 6% of malignant eccrine tumours.…”

Section: Discussionmentioning

confidence: 99%

Hidradenocarcinoma of scalp: a case report and review of literature

Gandla

Chatterjee

Patil

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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<p>Hidradenocarcinoma of the scalp is a rare skin adnexal tumour accounting for less than 0.001% of all tumors. In this study, we describe a rare presentation of the hidradenocarcinoma of the scalp in a 64 years old man. Patient presented with a right side scalp lesion in the occipital area, for which biopsy was done which showed hidradenocarcinoma. Patient underwent wide local excision of the posterior scalp lesion and posterolateral neck dissection and the patient was advised to receive adjuvant chemotherapy and radiotherapy, but the patient refused to undergo adjuvant therapy. Six months postsurgery patient had local recurrence in the posterior margin resection area and lung metastasis, which could have been prevented by adjuvant therapy. Malignant hidradenocarcinoma is a rare aggressive malignant tumour. Patients with this tumour should undergo surgical excision followed by adjuvant therapy.</p>

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Clear-cell hidradenoma.Report of three cases with widespread metastases

Cited by 164 publications

References 13 publications

Atypical and malignant hidradenomas: a histological and immunohistochemical study

Atypical and malignant hidradenomas: a histological and immunohistochemical study

Giant Hidradenoma of Limbs: A Report of Two Pediatric Cases

Hidradenocarcinoma of scalp: a case report and review of literature

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