Clear cell mesothelioma presenting as an incarcerated abdominal hernia

Ordóñez, Nelson G.

doi:10.1007/s00428-005-0023-2

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…Clinically, primary peritoneal epithelioid mesothelioma of clear cell type occurs mainly in aged people (Table 8 ). [ 3 , 8 – 11 ] The majority of patients were males (male: female ratio of 6:2).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics of primary peritoneal epithelioid mesothelioma of clear cell type

Du¹,

Wei²,

Gao³

et al. 2021

Medicine

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Rationale: Primary peritoneal epithelioid mesothelioma of clear cell type is an extremely rare entity composed of clear cytoplasm. It is challenging to diagnose because of the morphological resemblance to clear cell tumor. Patient's concerns: A 69-year-old male patient had swollen lymph nodes in the right inguinal region for 7 months and was constipated for 1 month. Diagnosis: The patient was diagnosed as peritoneal epithelioid mesothelioma of clear cell type based on computed tomography scan, pathology, immunohistochemistry, special staining and whole-exome sequencing. This patient harbored VHL gene alteration in exon 1 and homologous recombination defect (with a score of 45). This finding indicated that this patient might be sensitive to platinum-based therapy and Poly ADP-ribose Polymerase (PARP) inhibitor. This patient carried no microsatellite instability, a low level of tumor mutation burden, and a high extent of intratumoral heterogeneity. Eighteen neoantigens were detected. Interventions: The patient received surgery-based multidisciplinary treatment by integrating cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). HIPEC was administered with docetaxel 120 mg plus cisplatin 120 mg, at 43°C, for 60 minutes. After operation, the patient received intravenous (IV) chemotherapy with docetaxel 60 mg, pemetrexed 750 mg and cisplatin 100 mg, and then intraperitoneal (IP) chemotherapy with docetaxel 40 mg. The patient received interventional therapy of hepatic artery embolization for 5 times. Outcomes: Regular follow-up was performed until Oct 14, 2020. The patient died 31.6 months later owing to incomplete intestinal obstruction. Lessons: Primary peritoneal epithelioid mesothelioma of clear cell type needs to be differentiated from a variety of clear cell tumors. This disease is characterized by specific genetic alteration. Whole-exome sequencing contributes to guide individualized therapy. CRS-HIPEC helps achieve long-term overall survival.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics of primary peritoneal epithelioid mesothelioma of clear cell type

Du¹,

Wei²,

Gao³

et al. 2021

Medicine

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“…Among the aforementioned markers, calretinin, a vitamin D-dependent calcium-binding protein, is the most definitive in differentiating mesothelioma from adenocarcinoma ( 26 ); calretinin is largely present in mesothelioma, but absent in adenocarcinoma. Renal cell carcinoma may also complicate the diagnosis of MPM; calretinin and cytokeratin are positively expressed in epithelioid mesothelioma, but not in renal cell carcinoma ( 8 ). Strong EMA expression and negative desmin expression also indicate malignant mesothelioma, and may be used as reliable markers to distinguish malignant mesothelioma from benign reactive mesothelial proliferation ( 2 , 25 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

“…In rare cases, tumors may exhibit deciduoid, pleomorphic, signet-ring or clear cell features ( 6 ). Clear cell-type mesothelioma is extremely rare, with only a few individual case reports published previously ( 1 , 6 – 8 ). In the present study, a rare case of clear cell MPM is reported in a 60-year-old female with no history of asbestos exposure.…”

Section: Introductionmentioning

confidence: 99%

Malignant peritoneal mesothelioma in a patient with intestinal fistula, incisional hernia and abdominal infection: A case report

Hong

Zhao

et al. 2016

Oncology Letters

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Malignant mesothelioma is a rare type of cancer, most commonly associated with exposure to asbestos. Mesothelioma of the peritoneum, the membrane lining the abdominal cavity, is extremely rare. The current study reports the case of a 60-year-old female who presented with intestinal fistula, recurrent incisional hernia and abdominal infection, with no history of asbestos exposure, and was diagnosed with clear cell MPM. Computed tomography scans of the abdomen revealed extensive small bowel adhesions and massive peritoneal effusion. Histological examination of biopsy specimens indicated a diagnosis of malignant peritoneal mesothelioma with clear cell morphology. A laparotomy was performed, with subsequent resection of the bowel with fistula. Follow-up examination performed at 1-year post-surgery revealed that the patient was alive and in generally good health.

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“…Squamous cell carcinomas may present with clear cell features, due to the accumulation of intracytoplasmic glycogen [7]. Markers used to differentiate their pleural metastases from mesothelioma include p63, Ber-EP4, and CEA.…”

Section: Ultrastructural Pathologymentioning

confidence: 99%

“…After their first description in 1996 by Ordóñez et al [2], only a few cases of epithelioid mesotheliomas with clear cell morphology have since been described [3][4][5][6][7]. Pathologists should be aware of this uncommon type of clear cell mesothelioma in order to avoid misdiagnosis.…”

Section: Introductionmentioning

confidence: 97%

Primary Pleural Epithelioid Mesothelioma of Clear Cell Type: A Case Report and Review of Current Literature

Gkogkou¹,

Samitas²,

Foteinou³

2011

Ultrastructural Pathology

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Primary pleural epithelioid mesothelioma with clear cell morphology is a particularly rare neoplasm, with only a few documented cases. Here, the authors report a case of a 76-year-old man, with a history of asbestos exposure, admitted for mild dyspnea. Radiologic examination revealed right pleural effusion and pleural thickening. Cytological examination of aspirated pleural samples was consistent with non-small cell carcinoma. Histological examination of the resected, via VATS, plural specimens was consistent with the diagnosis of clear cell epithelioid mesothelioma. The authors further analyze the main morphological and immunohistochemical features of clear cell epithelioid mesothelioma, emphasizing the algorithm for excluding other clear cell tumors metastatic to the pleura.

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Clear cell mesothelioma presenting as an incarcerated abdominal hernia

Cited by 10 publications

References 26 publications

Clinicopathological characteristics of primary peritoneal epithelioid mesothelioma of clear cell type

Clinicopathological characteristics of primary peritoneal epithelioid mesothelioma of clear cell type

Malignant peritoneal mesothelioma in a patient with intestinal fistula, incisional hernia and abdominal infection: A case report

Primary Pleural Epithelioid Mesothelioma of Clear Cell Type: A Case Report and Review of Current Literature

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