Clear cell myoepithelial carcinoma of minor salivary gland: a case report

Yang, Shaodong; Zeng, Ming; Zhang, J.; Chen, Xinming

doi:10.1016/j.ijom.2009.10.013

Cited by 9 publications

(8 citation statements)

References 9 publications

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“…Past reports and reviews have suggested candidate markers to predict the prognosis of MEC (Table 1). MECs originating from a minor salivary gland reportedly have relatively better prognoses [17]. However, whether prognosis for MEC ex benign tumor, particularly PA, is better than for de novo MEC remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports

et al. 2016

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BackgroundMyoepithelial carcinoma (MEC) is a rare salivary gland tumor. Its long-term prognosis remains unknown because of the paucity of reported cases with long-term follow-up. Although some case series exist, the clinical features of MEC vary considerably depending on the site of origin. Therefore, accumulation of these rare cases is important.Case presentationCase 1: An 89-year-old man presented with a 10-year history of a mass originating from the right parotid gland and involving the neck. The mass grew rapidly for 3 months, reaching approximately 8 cm. There was no facial paralysis. MEC ex pleomorphic adenoma (PA) was suspected. Superficial parotid gland resection was performed in 2013; the tumor grade was pT3N0M0, and the resection margins were free of carcinoma. Because of several high-risk factors for metastasis (i.e., invasive carcinoma ex PA, high MIB1 index, and mutant p53 protein positivity), radiotherapy and chemotherapy were recommended as adjuvant therapy. Although the patient refused adjuvant therapy, he was recurrence-free at 36 months after surgery.Case 2: A 54-year-old woman presented with a >10-year history of a right submandibular mass, which grew rapidly for 1 year, reaching approximately 6 cm. Preoperative diagnosis was PA of the right submandibular gland. Submandibular gland resection was performed in 2013. Pathological analysis revealed invasive MEC ex PA, pT3N0M0; in addition, the carcinoma portion had an extra capsule and had invaded the platysma muscle close to the margin. An MIB1 index of 40 % and mutant p53 protein positivity indicated a high risk for metastasis. Additional resection and right neck dissection revealed no residual carcinoma. The patient refused adjuvant chemotherapy. One year after surgery, metastasis to the right pulmonary hilar node and both lungs were detected. Chemotherapy prevented recurrent growth of the lesion and extended survival. The patient was alive with cancer 30 months after the first surgery.ConclusionsHigh expression of the Ki67 labeling index might reflect prognosis of these cases. Chemotherapy for distant metastasis was effective, as expected. Further accumulation of cases and long follow-up data are needed to elucidate the pathophysiology and prognosis of MEC ex PA.

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Section: Discussionmentioning

confidence: 99%

Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports

et al. 2016

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“…The cellular configurations in myoepithelial carcinoma are the same as those in benign myoepithelioma these include spindle,[19] plasmacytoid, epithelioid, clear and mixed cells. [2021] The epithelioid cell type is the most common and purely clear cell myoepithelial carcinomas are rare and hard to distinguish from other types of clear cell neoplasms. [418]…”

Section: Discussionmentioning

confidence: 99%

“…For myoepithelial carcinoma, complete excision with tumor-free margin remains the first choice of treatment,[6171822] in spite of the possibilities of local recurrence and distant metastasis to lung, kidney and brain. [220] Adjuvant radiotherapy and postoperative chemotherapy do not seem to improve their prognosis significantly. The role of radiation in the treatment of malignant myoepithelioma is still controversial.…”

Section: Discussionmentioning

confidence: 99%

Myoepithelial carcinoma of buccal mucosa: A rare tumor

Lata

Ahmad²,

Chand³

2014

Contemp Clin Dent

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Myoepithelial carcinoma is a rare neoplasm of salivary glands that account for < 1% of all salivary gland tumors. The most common sites of involvement are major salivary glands mainly parotid gland. Intraorally, it can arise from minor salivary glands; palate is the most common site of occurrence. It also occurs in nasopharynx, paranasal sinuses, nasal cavity and larynx in head and neck region. Myoepithelial tumors were first described in 1943. Their malignant variant, myoepithelial carcinoma, was first reported by Stromeyer et al., in 1975, characterized by distinct morphologic heterogeneity and an infiltrative growth pattern into adjacent tissues. Here, we report a rare case of a 55-year-old female with myoepithelial carcinoma of buccal mucosa. It was also rare because of unusual location of tumor. Our patient was treated with wide local resection and remained free of disease for 15 months.

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“…By examination of the site of tumor development, 9 cases involved the parotid gland, 4 cases involved the submandibular gland and one case involved the maxillary sinus. Three cases occurred in the oral cavity, 2 cases occurred in the palate and one case occurred in the retromolar region (2)(3)(4)(5)(6)(7). This is the first study to report a case of CCMC in the base of the tongue.…”

Section: Discussionmentioning

confidence: 99%

Clear cell myoepithelial carcinoma in the base of the tongue: Case report and review of the literature

et al. 2012

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Abstract. Clear cell myoepithelial carcinoma is a very rare disease which develops primarily in the parotid gland. To date, only 17 cases of clear cell myoepithelial carcinoma have been reported worldwide. Among them, only three cases developed in the minor salivary gland in the oral cavity. No cases developed in the base of the tongue. Here, we report a new case of clear cell myoepithelial carcinoma that developed in the tongue base of a 52-year-old female patient. A mass was discovered on the left side of the tongue base. We successfully removed the mass through suprahyoid pharyngotomy approach. The light microscopy examination and various immunohistochemical stainings revealed clear cell myoepithelial carcinoma. During a two year follow-up period, there was no recurrence or local or distant metastasis.

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Clear cell myoepithelial carcinoma of minor salivary gland: a case report

Cited by 9 publications

References 9 publications

Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports

Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports

Myoepithelial carcinoma of buccal mucosa: A rare tumor

Clear cell myoepithelial carcinoma in the base of the tongue: Case report and review of the literature

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