Clear Cell Variant of Malignant Melanoma of the Uterine Cervix: A Case Report and Review of the Literature

Primary amelanotic melanoma of the cervix: case report with review of literature

“…An occasional series or case reports have been documenting amelanotic melanoma originating exclusively in the vulva and uterine cervix. [2][3][4][5][6][7][8][9] Ragnarsson-Olding reported that 27% of all vulvar melanomas are amelanotic type, however the incidence of cervical amelanotic melanoma is not yet known.…”

“…[3][4][5][6][7][8][9] Moreover, delayed diagnosis and advanced stage can further increase the difficulty in management. For amelanotic melanoma in the cervix, most authors have recommended radical hysterectomy and if necessary, to obtain clean surgical margins of at least 2 cm.…”

“…However, the prognosis is usually poor, most patients die within 3 years of diagnosis. [7][8][9] Biopsy for the malignant melanoma in cervix has high misdiagnosis rate. Special staining and immunohistochemistry should be resorted to, whenever needed, to reach the diagnosis of amelanotic melanoma as early as possible.…”

“…The absence or rarity of melanin granules in amelanotic melanomas can lead to their misdiagnoses as carcinomas, sarcomas or lymphoma. [2][3][4][5][6][7][8][9] In this context, ancillary immunohistochemistry is of value and the use of vimentin, S-100 and HMB-45 monoclonal antibody is reported to vastly improve the accuracy of diagnosing malignant melanomas. [3][4][5][6][7][8][9] We present a rare case of primary amelanotic melanoma of the cervix, which was initially suspected to be a poorly differentiated malignant tumor with a wide differential diagnosis of carcinoma, sarcoma, lymphoma and amelanotic melanoma but was subsequently correctly diagnosed by immunohistochemistry.…”

Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature

“…No clear standard for management of this disease is observed. The difficulties in diagnosis and treatment in turn aggravate the poor prognosis [1][2][3]. Here we report two cases of AMFGT, originating in vulva and uterine cervix, respectively.…”