Primary amelanotic melanoma of the cervix: case report with review of literature

Duggal, Rajan; Srinivasan, Radhika

doi:10.3802/jgo.2010.21.3.199

Cited by 16 publications

(6 citation statements)

References 10 publications

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“…Amelanotic melanoma is rare in the uterine cervix and is frequently misdiagnosed as carcinoma, sarcoma or lymphoma as was seen in our case also 10. Definitive diagnosis can be achieved in immunohistochemical evaluation using monoclonal antibodies for S100 (more sensitive), HMB45 (more specific), Melan-A and antityrosinase.…”

Section: Discussionmentioning

confidence: 51%

Primary amelanotic malignant melanoma of cervix masquerading as squamous cell carcinoma presenting with extensive metastases

et al. 2018

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Amelanotic melanoma of cervix is a rare and aggressive neoplasm and only few cases have been reported in the literature. We report a rare case of an amelanotic melanoma of the uterine cervix with extensive metastases and multiple subcutaneous nodules. Due to the unusual site and amelanotic nature of the lesion, chances of misdiagnosis are high and immunohistochemical markers for melanoma help establish the diagnosis. The possibility of metastasis from a primary malignant melanoma of the skin needs to be ruled out. The present case was initially misdiagnosed and treated on the regimen for squamous cell carcinoma, but progressed despite chemotherapy. After a thorough re-evaluation and applying extensive panel of immunohistochemistry, the diagnosis of an amelanotic malignant melanoma of uterine cervix was established.

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Section: Discussionmentioning

confidence: 51%

Primary amelanotic malignant melanoma of cervix masquerading as squamous cell carcinoma presenting with extensive metastases

et al. 2018

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“…In such cases, the differential diagnoses included poorly differentiated carcinoma, sarcoma or lymphoma, warranting a panel of immunohistochemical stains to arrive at a definite diagnosis. Literature gives a small series of cases of amelanotic melanomas initially misdiagnosed as anaplastic carcinoma, clear cell carcinoma, chorioepithelioma, sarcoma and lymphoma [15]. In our case, the initial small biopsy was amelanotic, misleading us to a diagnosis of the most common primary entity seen here, that is, large cell non keratinizing squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 69%

Uterine Cervical Melanocytic Tumours—A Single Institution Experience with Review of Literature

Nair¹,

Rajanbabu²,

Jojo³

et al. 2016

OJOG

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Primary melanocytic tumours of the uterine cervix are rare. These include blue nevi and malignant melanoma. Blue nevi are benign melanocytic lesions which occur as incidental finding. Primary cervical melanomas are rare mucosal melanomas with aggressive behaviour. In small biopsies, they can mimic poorly differentiated carcinomas. Here we present the cases of melanocytic tumours reported from our institute during the last 6 years.

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“…[5] However, owing to the relatively limited blood supply and the presence of a fibrous stroma, which is not suitable for growth of a metastatic neoplasm, some controversy remains regarding metastases to the cervix. [6] Interestingly, in our patient, the tumor synchronously involved the vulva and uterine cervix. This presentation has not been reported earlier in the literature.…”

Section: Discussionmentioning

confidence: 70%

Primary malignant melanoma of the female genital tract synchronously involving the vulva and uterine cervix

et al. 2019

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Rationale Primary melanomas of the female genital tract are rare and usually occur in the vulva and vagina. Involvement of the cervix, uterus, and ovary are extremely rare. Surgery and adjuvant therapy remain the mainstay of treatment. The majority of patients experience poor long-term survival. This report aimed at highlighting an extremely rare case of primary melanoma of the female genitalia, synchronously involving the vulva and uterine cervix. Patient concerns A 58-year-old multiparous female presented with postmenopausal bleeding for 10 days. Diagnoses Speculum examination and histologic analysis of the surgical specimens revealed synchronous involvement of the vulva and uterine cervix by malignant melanoma. According to the American Joint Committee on Cancer stage grouping for melanoma, this tumor was at stage V. Interventions The patient subsequently underwent radical surgery and postoperative chemotherapy. Outcomes She has been on regular follow-up, and is now free of disease for 50 months after the operation. Lessons Primary melanomas of the female genital tract have biologically aggressive characteristics. Optimal management consists of individualized surgery and adjuvant therapy. However, early recognition and prompt intervention offer maximal benefit from treatment.

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Primary amelanotic melanoma of the cervix: case report with review of literature

Cited by 16 publications

References 10 publications

Primary amelanotic malignant melanoma of cervix masquerading as squamous cell carcinoma presenting with extensive metastases

Primary amelanotic malignant melanoma of cervix masquerading as squamous cell carcinoma presenting with extensive metastases

Uterine Cervical Melanocytic Tumours—A Single Institution Experience with Review of Literature

Primary malignant melanoma of the female genital tract synchronously involving the vulva and uterine cervix

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