Clearance of a Thick Invasive Squamous Cell Carcinoma After Multiple Treatments with Topical Photodynamic Therapy

Li, Qiang; Gao, Tianwen; Long, Heather A.; Ujiie, Hideyuki

doi:10.1089/pho.2009.2610

Cited by 16 publications

(6 citation statements)

References 29 publications

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“…Also for MAL-PDT, the efficacy of the technique is inversely related to the thickening of the lesion, as consequence of the physical ability of the luminous radiation to penetrate the skin. A study conducted on 95 BCCs of different thickness, stratified the results depending on the thickness of the lesion, as it follows: CR in lesions with thickness less than 1.3 mm, partial response in lesions between 1.3 and 1.8 mm and lack of response in those that exceeded 1.8 mm in thickness, with a two-year overall response rate of 75.8% [ 76 ].…”

Section: Pdt In the Treatment Of Localized Bccmentioning

confidence: 99%

Usefulness of Photodynamic Therapy as a Possible Therapeutic Alternative in the Treatment of Basal Cell Carcinoma

Savoia

Deboli

Previgliano

et al. 2015

IJMS

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Basal cell carcinoma (BCC) is the most common cancer in individuals with fair skin type (I–II) and steadily increasing in incidence (70% of skin malignancy). It is locally invasive but metastasis is usually very rare, with an estimated incidence of 0.0028%–0.55%. Conventional therapy is surgery, especially for the H region of the face and infiltrative lesions; in case of inoperable tumors, radiotherapy is a valid option. Recently, topical photodynamic therapy (PDT) has become an effective treatment in the management of superficial and small nodular BCC. PDT is a minimally invasive procedure that involves the administration of a photo-sensibilizing agent followed by irradiation at a pre-defined wavelength; this determines the creation of reactive oxygen species that specifically destroy target cells. The only major side effect is pain, reported by some patients during the irradiation. The high cure rate and excellent cosmetic outcome requires considering this possibility for the management of patients with both sporadic and hereditary BCC. In this article, an extensive review of the recent literature was made, in order to clarify the role of PDT as a possible alternative therapeutic option in the treatment of BCC.

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Section: Pdt In the Treatment Of Localized Bccmentioning

confidence: 99%

Usefulness of Photodynamic Therapy as a Possible Therapeutic Alternative in the Treatment of Basal Cell Carcinoma

Savoia

Deboli

Previgliano

et al. 2015

IJMS

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“…Recent studies have compared excimer dye and metal halide light sources and red and green light, but the literature is consistent that depth of light penetration correlates with clearance rate. 34 One case has shown successful treatment of an SCC with 5.5-cm 5 It may even be considered as first-line therapy for large or widespread lesions or those in difficult to treat areas.…”

Section: Bowen's Diseasementioning

confidence: 99%

“…34 A small case series evaluated MAL-PDT in the treatment of keratoacanthomas. 34 A small case series evaluated MAL-PDT in the treatment of keratoacanthomas.…”

Section: Bowen's Diseasementioning

confidence: 99%

“…Usually thickness less than 2 to 3 mm below the epidermis is considered the effective response depth. 34 One case has shown successful treatment of an SCC with 5.5-cm…”

Section: Bowen's Diseasementioning

confidence: 99%

“…depth using seven treatments of MAL-PDT 1 week apart at 791 J/cm 2 . 34 A small case series evaluated MAL-PDT in the treatment of keratoacanthomas. 35 All four lesions disappeared completely, with no recurrence at 3 years and excellent cosmetic outcomes.…”

Section: Bowen's Diseasementioning

confidence: 99%

See 2 more Smart Citations

Spotlighting the Role of Photodynamic Therapy in Cutaneous Malignancy: An Update and Expansion

Ross¹,

Cherpelis²,

Lien³

et al. 2013

Dermatologic Surgery

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We find sufficient evidence to recommend the use of PDT in certain patients in the treatment of AK, Bowen's disease, sBCC, and nBCC. It is especially useful in those with contraindications to surgery, widespread areas of involvement, and large lesions. Not only can it be considered superior to other therapies as far as recovery time, tolerance, and cosmetic outcomes, but it also should be considered, when indicated, as first-line treatment in the above conditions. Investigations continue for the use of PDT in the treatment of melanoma, SCC, chemoprevention, and CTCL.

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A Comprehensive Analysis of Near‐Contact Photobiomodulation Therapy in the Host–Bacteria Interaction Model Using 3D‐Printed Modular LED Platform

et al. 2020

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One well‐studied bacterial factor recognized by the host immune system is lipopolysaccharides (LPS) that stimulate host cells, resulting in cell inflammation. Although photobiomodulation (PBM) therapy demonstrates its potency on anti‐inflammatory activity, the complete mechanism of action in the host–bacteria interaction model is still elusive. In addition, many studies were performed regarding a distance between the light source and biological sample (non‐contact therapy) that may result in disparate reports on the efficacy of PBM therapy. Thus, it is critical to clearly understand the effect of this approach to maximize efficacy and minimize side effects. Here, a custom‐built light‐emitting diode (LED) platform that mimics near‐contact therapy is developed. The effect and mechanism of PBM therapy on epithelial cells in response to LPS is systematically investigated under various conditions (wavelength, irradiation‐time, pulse‐frequency). The data show that the irradiation of near‐infrared (NIR‐LED) significantly improves the viability of inflamed cells. It reveals that NIR‐LED inhibits the production of reactive oxygen species by regulating the Nox4‐NF‐κB pathway. Interestingly, however, high‐pulse frequency stimulus causes the collapse of the mitochondrial membrane potential (ΔΨm) of cells, resulting in cell death. These results suggest that the optimized “PBM condition” is critical to assist the healthy immune system of the host against bacterial invasion.

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Clearance of a Thick Invasive Squamous Cell Carcinoma After Multiple Treatments with Topical Photodynamic Therapy

Abstract: PDT may offer a noninvasive, well-tolerated, and effective therapy for inoperable low-risk SCC with an outgrowing pattern. It suggests that tumor depth is not an absolute predictor, but only a suggested reference.

Cited by 16 publications

References 29 publications

Usefulness of Photodynamic Therapy as a Possible Therapeutic Alternative in the Treatment of Basal Cell Carcinoma

Usefulness of Photodynamic Therapy as a Possible Therapeutic Alternative in the Treatment of Basal Cell Carcinoma

Spotlighting the Role of Photodynamic Therapy in Cutaneous Malignancy: An Update and Expansion

A Comprehensive Analysis of Near‐Contact Photobiomodulation Therapy in the Host–Bacteria Interaction Model Using 3D‐Printed Modular LED Platform

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