Spotlighting the Role of Photodynamic Therapy in Cutaneous Malignancy: An Update and Expansion

Abstract

We find sufficient evidence to recommend the use of PDT in certain patients in the treatment of AK, Bowen's disease, sBCC, and nBCC. It is especially useful in those with contraindications to surgery, widespread areas of involvement, and large lesions. Not only can it be considered superior to other therapies as far as recovery time, tolerance, and cosmetic outcomes, but it also should be considered, when indicated, as first-line treatment in the above conditions. Investigations continue for the use of PDT in the treatment of melanoma, SCC, chemoprevention, and CTCL.

Nonthermal Ablation by Using Intravascular Oxygen Radical Generation with WST11: Dynamic Tissue Effects and Implications for Focal Therapy

“…As observed in trials with small animals (19), when WST11 is activated by light, super oxide and hydroxyl radicals produced in the blood mediate a cascade of events that resemble profound, transient, and localized ischemia-reperfusion injury that results in a complete tumor vascular arrest, including feeding arteries and draining veins, followed by localized necrosis (19,20). WST11 VTP profoundly differs from classic photodynamic therapy (21)(22)(23)(24)(25)(26)(27) and offers major advantages, including absence of prolonged toxicity, a major drawback of classic photodynamic therapy (4,(28)(29)(30). WST11 VTP was applied successfully and safely in phase II clinical trials in patients with early-stage prostate cancer (31).…”

Er:YAG ablative fractional laser‐primed photodynamic therapy with methyl aminolevulinate as an alternative treatment option for patients with thin nodular basal cell carcinoma: 12‐month follow‐up results of a randomized, prospective, comparative trial

“…4 Despite having some negative consequences, PDT is especially useful for patients who have contraindications for surgery, widespread areas of involvement or large lesions. 5 Its recovery time, tolerance and cosmetic outcome can be considered superior to those of other treatments. 5 Topical PDT with methyl aminolevulinate (MAL-PDT) has been introduced as an alternative procedure for BCC.…”

“…5 Its recovery time, tolerance and cosmetic outcome can be considered superior to those of other treatments. 5 Topical PDT with methyl aminolevulinate (MAL-PDT) has been introduced as an alternative procedure for BCC. 6 However, conventional PDT is considered to be an inappropriate method of treating nodular BCC (nBCC) because of its lower efficacy.…”

The preparation of rat’s acellular spinal cord scaffold and co-culture with rat’s spinal cord neuron in vitro

“…The study of Ribatti et al showed that the prepared natural acellular material promoted the growth of vascular cells. 61 In this experiment, the rat's spinal cord neurons and ASCS were co-cultured in vitro, the results showed that the neurons grew in good condition in the channel space of the ASCS. Cell axons were intact and also grew in good condition.…”