Clearance of cardiac troponin T with and without kidney function

Fridén, Vincent; Starnberg, Karin; Muslimović, Aida; Ricksten, Sven‐Erik; Bjurman, Christian; Forsgard, Niklas; Wickman, Anna; Hammarsten, Ola

doi:10.1016/j.clinbiochem.2017.02.007

Cited by 110 publications

(98 citation statements)

References 36 publications

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“…Intact and degraded cTnI are detectable by immunoblot as early as 90 minutes after onset of symptoms with additional degradation products detectable at 165 minutes [29]. Although renal function influences cTnI clearance [30], the overall magnitude and its influence on the diagnostic accuracy of cTnI in patients with AMI remains unclear.…”

Section: Limitations and Open Questions In Clinical Ctni Biomarker Anmentioning

confidence: 99%

The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform

Soetkamp

Raedschelders

Mastali

et al. 2017

Expert Review of Proteomics

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Introduction: The troponin complex consists of three proteins that fundamentally couple excitation with contraction. Circulating cardiac-specific Troponin I (cTnI) serves as diagnostic biomarker tools for risk stratification of acute coronary syndromes and acute myocardial infarction (MI). Within the heart, cTnI oscillates between inactive and active conformations to either block or disinhibit actinomyosin formation. This molecular mechanism is fine-tuned through extensive protein modifications whose profiles are maladaptively altered with co-morbidities including hypertrophic cardiomyopathy, diabetes, and heart failure. Technological advances in analytical platforms over the last decade enable routine baseline cTnI analysis in patients without cardiovascular complications, and hold potential to expand cTnI readouts that include modified cTnI proteoforms. Areas covered: This review covers the current state, advances, and prospects of analytical platforms that now enable routine baseline cTnI analysis in patients. In parallel, improved mass spectrometry instrumentation and workflows already reveal an array of modified cTnI proteoforms with promising diagnostic implications. Expert commentary: New analytical capabilities provide clinicians and researchers with an opportunity to address important questions surrounding circulating cTnI in the improved diagnosis of specific patient cohorts. These techniques also hold considerable promise for new predictive and prescriptive applications for individualized profiling and improve patient care.

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Section: Limitations and Open Questions In Clinical Ctni Biomarker Anmentioning

confidence: 99%

The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform

Soetkamp

Raedschelders

Mastali

et al. 2017

Expert Review of Proteomics

View full text Add to dashboard Cite

show abstract

“…Immer et al found a prolonged postoperative course after open heart surgery in children, presenting with higher TnI levels at ICU admission after surgery. Nevertheless, patients with higher TnI levels also showed a reduced renal function in comparison to those patients with lower TnI values, which needs to be discussed as a confounding parameter, even though TnI clearance is less dependent on renal function than TnT . In all these analysis, dTGA patients are only a subgroup of CHD and not analyzed separately.…”

Section: Discussionmentioning

confidence: 99%

“…TnT. 25 In all these analysis, dTGA patients are only a subgroup of CHD and not analyzed separately. Imura et al 26 focused on TnI values up to 48 h after ASO in 31 neonates with simple and complex TGA.…”

Section: Troponin T Valuesmentioning

confidence: 99%

Risk factor analysis for a complicated postoperative course after neonatal arterial switch operation: The role of troponin T

Christmann

Wipf

Dave

et al. 2018

Congenital Heart Disease

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“…Rather, cTn reflects the evidence of ongoing myocyte damage [1], clinically silent "micro-MI" [5], or left ventricular hypertrophy [6]. Studies from rats with or without clamped kidney vessels showed that at high levels of cTnT similar to those observed after a large MI extrarenal clearance dominates, whereby there was no difference in cTnT clearance in rats with intact kidney function [7]. However, kidney clearance does play a role in the setting of stable low cTnT levels.…”

Section: Cardiac Troponinmentioning

confidence: 99%

“…However, kidney clearance does play a role in the setting of stable low cTnT levels. Fridén et al [7] examined 3 heart failure patients undergoing renal vein catheterization and determined the extraction index of cTnT to be 8-19%.…”

Section: Cardiac Troponinmentioning

confidence: 99%

Utility of Cardiac Biomarkers in the Setting of Kidney Disease

Savoj

Becerra

Kim

et al. 2019

Nephron

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Cardiovascular disease is prevalent in patients with chronic kidney disease (CKD) and responsible for approximately half of all CKD-related deaths. Unfortunately, the presence of CKD can lead to a challenging interpretation of cardiac biomarkers essential in accurate diagnosis and prompt management of heart failure and acute coronary syndrome. There is growing interest in novel cardiac biomarkers that may improve diagnostic accuracy reflecting myocardial injury, inflammation, and remodeling. Interpretation of these biomarkers in CKD can be complicated, since elevated levels may not reflect myocardial injury or wall tension but rather decreased urinary clearance with retention of solutes and/or overall CKD-associated chronic inflammation. In this review, we discuss the latest data on major and emerging cardiac biomarkers including B-type natriuretic peptide, troponin, suppression of tumorigenicity 2, growth and differentiation factor-15, galectin-3, and matrix gla protein, and their diagnostic and prognostic utility in the CKD population.

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Clearance of cardiac troponin T with and without kidney function

Cited by 110 publications

References 36 publications

The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform

The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform

Risk factor analysis for a complicated postoperative course after neonatal arterial switch operation: The role of troponin T

Utility of Cardiac Biomarkers in the Setting of Kidney Disease

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