Clerodane diterpenes of croton ururucana

Peres, Marize Terezinha Lopes Pereira; Pizzolatti, Moacir Geraldo; Yunes, Rosendo A.; Monachè, Franco Delle

doi:10.1016/s0031-9422(97)00873-x

Cited by 24 publications

(23 citation statements)

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“…The semipurified FDM and FAE fractions caused expressive mortality to A. kuehniella larvae, especially FAE (2.0%), reaching 100% mortality rate. Previous chemical studies on this fraction resulted in the isolation of the phenolic compounds catechin and gallocatechin, which played a role in the insecticidal activity (Peres et al, 1998). According to Shirley (2001) condensed tannins, catechin and gallocatechin are phenolic compounds responsible for the astringency of many fruits as well as defense against the pests, as they attach to insects' digestive proteins, becoming an important mechanism for the plant defense against the pathogens .…”

Section: Discussionmentioning

confidence: 99%

“…The methanolic extract from J. curcas has insecticidal activity against Helicoverpa armigera (Lepidoptera) and Sitophilus zeamais (Coleoptera) (Solsoloy, 1995), and Culex quinquefasciatus (Diptera) (Karmegam et al, 1997). Although innumerous species of the genus Croton (Euphorbiaceae) present several biological activities (Peres et al,1997 and1998;Suárez et al, 2003;Anazetti et al, 2004;Fisher et al, 2004), there are no reports for Croton urucurana on insecticidal, deterrent, repellent activities or inhibiting action on insects' digestive enzymes. Anagasta kuehniella (Zeller) (Lepidoptera: Pyralidae), popularly known as Mediterranean flour moth is found worldwide, particularly in the stored grains as a flour and grain feeder: it is often a severe pest in flour mills.…”

Section: Introductionmentioning

confidence: 99%

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Effects of croton urucurana extracts and crude resin on Anagasta kuehniella (Lepidoptera: Pyralidae)

Silva

Macedo

et al. 2009

Braz. arch. biol. technol.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of croton urucurana extracts and crude resin on Anagasta kuehniella (Lepidoptera: Pyralidae)

Silva

Macedo

et al. 2009

Braz. arch. biol. technol.

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“…13,15,16 Fucoarabinogalactan, a polysaccharide, has been isolated from the gum exudate of C. urucurana. 17 In this study, we report the chemical composition, antioxidant 29 and antimicrobial activities of the essential oil obtained from the stem bark of Croton urucurana.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and evaluation of antibacterial and antioxidant activities of the essential oil of Croton urucurana Baillon (Euphorbiaceae) stem bark

Simionatto¹,

Bonani²,

Morel³

et al. 2007

J. Braz. Chem. Soc.

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O óleo essencial obtido a partir das cascas do caule de Croton urucurana Baillon (Euphorbiaceae) foi analisado por CG e CG-EM. 83 compostos foram identificados, sendo borneol (14,7%), acetato de bornila (5,2%), 1-isopropil-7-metil-4-metileno-1,3,4,5,6,8-hexaidro-2H-naftalen-4a-ol (14,7%), sesquicineol (10,5%) e epóxido de γ-gurjuneno (5,4%) os principais componentes. Para o óleo essencial bruto, foi determinada em 3,21 mg mL -1 a EC 50 no ensaio de atividade antioxidante frente ao radical livre DPPH. A fração do óleo essencial bruto que apresentou atividade antioxidante foi purificada por CCD sobre sílica gel. Análises de CG e CG-EM revelaram que α-bisabolol (38,3%), α-eudesmol (9,3%) e guaiol (8,2%) são os principais componentes da fração antioxidante. A EC 50 medida no teste frente ao DPPH foi de 1,05 mg mL -1 para a fração bioativa. Foi determinada a atividade antimicrobiana do óleo essencial bruto frente a sete bactérias Gram-positivas e Gram-negativas e três fungos. Os valores de CIM medidos variaram de 1,25 a 10,00 mg mL -1 .The essential oil obtained from the stem bark of Croton urucurana Baillon (Euphorbiaceae) was analysed by GC and GC-MS. 83 compounds were identified and borneol (14.7%), bornyl acetate (5.2%), 1-isopropyl-7-methyl-4-methylene-1,3,4,5,6,8-hexahydro-2H-naphthalen-4a-ol (14.7%), sesquicineole (10.5%) and γ-gurjunene epoxide (5.4%) were the main components. The EC 50 value of the crude essential oil in the DPPH free radical scavenging assay was 3.21 mg mL -1 . The fraction of the crude essential oil that presented antioxidant activity was purified by prep-TLC on silica gel. GC and GC-MS analysis revealed that α-bisabolol (38.3%), α-eudesmol (9.3%) and guaiol (8.2%) were the main components of the antioxidant fraction. The EC 50 value measured for the bioactive oil fraction in the DPPH assay was 1.05 mg mL -1 . The antimicrobial activity of the crude essential oil was assayed against seven Gram-positive and Gram-negative bacteria and three yeasts. Measured MIC values ranged from 1.25 to 10.00 mg mL -1 . Keywords:Croton urucurana, essential oil, antioxidant, DPPH assay, antimicrobial acticity IntroductionCroton (Euphorbiaceae) is one of the largest genera of flowering plants, with nearly 1,300 species of herbs, shrubs, and trees that are ecologically prominent and often important elements of secondary vegetation in the tropics and subtropics worldwide. Previous works reported that the essential oils from northeastern Brazilian Croton species, C. zenhtneri, C. nepetaefolius and C. argyrophylloides, exhibited good antioxidant activities. 9 Croton urucurana Baillon (Euphorbiaceae) is a tree commonly found in Paraguay, northern Argentina, southern Brazil, and Uruguay. Three different products from this species are used primarily in folk medicine: the red sap, the stem bark, and the gum exudate. 10 Many pharmacological effects of Croton urucurana have been described in literature, which include wound and ulcer healing, antidiarrhoeic, anticancer, intestinal anti-inflammatory, antioxidant and an...

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“…As cascas de C. urucurana, descrevem a presença de ácido acetilaleuritólico; dos flavonóides catequina e galocatequina; dos diterpenos clerodanos sonderianino, 12-epi-metilbarsbacoato e 15,16-epoxy-3,13(16)-clerodatrieno-2-ona; e dos esteróis: campesterol, stigmasterol, sitosterol e seu glicosídeo (PERES et al, 1997;PERES et al, 1998a;PERES et al, 1998b). A atividade antitumoral de vários flavonóides está atribuída a sua eficiência em inibir as enzimas topoisomerases I e II (SUKAR-DIMAN et al, 2000), diminuir a proliferação celular como consequência de sua ligação ao receptor de estrógeno (PRIMIANO et al, 2001), apresentar atividade inibidora de proteínas quinases (GAMETPAYRASTRE et al, 1999), e/ou induzir apoptose e liberação do citocromo c (LU et al, 2010).…”

Section: Avaliação Do Mecanismo De Morte Celularunclassified

Atividade Citotóxica Do Extrato De Croton Urucurana Baill Contra Linhagens De Células Leucêmicas Humanas U937 E Thp1

Vieira

Oliveira

Monteiro

et al. 2017

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Clerodane diterpenes of croton ururucana

Cited by 24 publications

References 8 publications

Effects of croton urucurana extracts and crude resin on Anagasta kuehniella (Lepidoptera: Pyralidae)

Effects of croton urucurana extracts and crude resin on Anagasta kuehniella (Lepidoptera: Pyralidae)

Chemical composition and evaluation of antibacterial and antioxidant activities of the essential oil of Croton urucurana Baillon (Euphorbiaceae) stem bark

Atividade Citotóxica Do Extrato De Croton Urucurana Baill Contra Linhagens De Células Leucêmicas Humanas U937 E Thp1

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