Clerodane Diterpenoids from Croton crassifolius

Abstract

Seven new clerodane diterpenoids (1-7) were isolated from roots of Croton crassifolius, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of 1, 3, 4, and 7 were confirmed by single-crystal X-ray diffraction analyses. Compounds 1-13 were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay.

Halimane diterpenoids: sources, structures, nomenclature and biological activities

“…Other halimanes show interesting biological activities, such as antibacterial, 50 antiviral, 78 antifungal, 53 and antimalarial. 79 Others exert anti-inammatory, 45 anti-ulcerogenic, 80 antihyperlipidemic 81 or hepatogenic activities.…”

“…This journal is © The Royal Society of Chemistry 2018 The study of genus Halimium plants has made possible to determine the presence of ve chemotypes of Halimiun viscosum, known in accordance with the harvesting place: Villarino de los Aires, (Salamanca, Spain), 17 La Fregeneda, (Salamanca, Spain), 26,27 Valparaiso, (Zamora, Spain), 28 Celorico da Beira, (Portugal) 29 and San João da Pesqueira, (Portugal). 30 In this group, the Euphorbiaceae, 78,108,109,[111][112][113][114] Cistaceae, 17,26,27,29,30,110,[115][116][117][118] Leguminoseae, 48,119,120 Compositae, 21,24 Jungermanniaceae, 121 Velloziaceae 52 and Annonaceae 122,123 plant families have been studied together with marine organisms of genus Spurilla 124 and Agelas. 74,125 The most numerous compounds of this group (Fig.…”

“…8, Table S2 †). Compounds of this type have been isolated from plants of the families Euphorbiaceae, 44,78,105,107,109,[111][112][113][114][136][137][138][139][140][141][142][143][144][145][146][147][148][149][150][151] Compositae, 45 Annonaceae, 122 Lamiaceae, 91 Jungermanniaceae, 152,153 Asteraceae, 76 and Meliaceae, 154 and in sponges of genus Agelas. 79,135 Among them, chettaphanin II (102) 111 is found.…”

Diterpenoid Alkaloids from Delphinium ajacis and Their Anti-RSV Activities

“…As a part of our ongoing research to find the active antiviral compounds from Chinese medicinal plants [17][18][19][20], all of the isolated compounds were tested for their activities against RSV. As shown in ▶…”

New Cytotoxic Tigliane Diterpenoids from Croton caudatus

“…Phytochemical investigations on the genus Croton have revealed its predominant secondary metabolites as diterpenoids including clerodanes, kauranes, labdanes, tiglianes, etc. [1][2][3][4][5][6]. Among them, the latter attracted much attention due to their diverse structures and significant cytotoxic activity [6][7][8][9].…”