Climate change, airborne allergens, and three translational mitigation approaches

Beggs, Paul J.; Clot, Bernard; Sofiev, Mikhail; Johnston, Fay

doi:10.1016/j.ebiom.2023.104478

Cited by 16 publications

(12 citation statements)

References 84 publications

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“…Climate change is already having an impact on the seasonality, production, and concentration, allergenicity, and geographic dissemination of airborne allergens, with subsequent consequences on human allergic disease [ 30 , 31 ]. Tenerife is the largest and highest oceanic island of the Canary archipelago, with a climate dominated by the influence of the cool humid northeast trade winds, associated with the Azores anticyclone [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular Mapping of Allergen Exposome among Different Atopic Phenotypes

González‐Pérez

Poza‐Guedes

Pineda

et al. 2023

IJMS

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Climate change and exposure to environmental pollutants play a key role in the onset and aggravation of allergic diseases. As different climate-dependent patterns of molecular immunoglobulin E (IgE) reactivity have been regionally described, we sought to investigate the evolving allergen exposome in distinctive allergic phenotypes and subtropical weather conditions through a Precision Allergy Molecular Diagnosis (PAMD@) model. Concurrent sensitization to several house dust mites (HDM) and storage mite molecules were broadly dominant in the investigated cohort, followed by the major cat allergen Fel d 1, and regardless of the basal allergic disease. Although a complex repertoire of allergens was recognized, a steadily increasing number of IgE binding molecules was associated with the complexity of the underlying atopic disease. Besides the highly prevalent IgE responses to major HDM allergens, Der p 21, Der p 5, and Der p 7 also showed up as serodominant molecules, especially in subjects bothered by asthma and atopic dermatitis. The accurate characterization of the external exposome at the molecular level and their putative role as clinically relevant allergens is essential to elucidate the phenotypic diversity of atopic disease in terms of personalized diagnosis and therapy.

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Section: Discussionmentioning

confidence: 99%

Molecular Mapping of Allergen Exposome among Different Atopic Phenotypes

González‐Pérez

Poza‐Guedes

Pineda

et al. 2023

IJMS

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“…Among the most significant repercussions of environmental degradation and warming on human health lies in its influence on plant physiology and the behavior of airborne aeroallergens, thereby exacerbating allergic respiratory conditions like asthma and allergic rhinitis (15)(16)(17).…”

Section: Atmospheric Pollution and Climate Changementioning

confidence: 99%

Air pollution and rhinitis

Rosario,

Urrutia-Pereira,

Murrieta-Aguttes

et al. 2024

Front. Allergy

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Rhinitis arises from either allergic or non-allergic inflammation of the nasal mucosa, characterized by the infiltration of inflammatory cells into the tissue and nasal secretions, along with structural alterations in the nasal mucosa. The pathways through which air pollution affects rhinitis may diverge from those affecting asthma. This article aims to review the effects of diverse air pollutants on the nose, the correlation of climate change and pollution, and how they aggravate the symptoms of patients with rhinitis.

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“…Rising air temperatures and the escalation of atmospheric CO 2 levels can affect the timing, creation, concentration, allergenic properties, and global spread of airborne allergens such as pollen. This, in turn, will lead to repercussions on allergic respiratory conditions such as allergic asthma and rhinitis [154].…”

Section: Side Effects Allergies and Food Safetymentioning

confidence: 99%

Chemical Properties and Biological Activity of Bee Pollen

Rodríguez-Pólit,

Gonzalez-Pastor,

Heredia-Moya

et al. 2023

Molecules

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Pollen, a remarkably versatile natural compound collected by bees for its abundant source of proteins and nutrients, represents a rich reservoir of diverse bioactive compounds with noteworthy chemical and therapeutic potential. Its extensive biological effects have been known and exploited since ancient times. Today, there is an increased interest in finding natural compounds against oxidative stress, a factor that contributes to various diseases. Recent research has unraveled a multitude of biological activities associated with bee pollen, ranging from antioxidant, anti-inflammatory, antimicrobial, and antifungal properties to potential antiviral and anticancer applications. Comprehending the extensive repertoire of biological properties across various pollen sources remains challenging. By investigating a spectrum of pollen types and their chemical composition, this review produces an updated analysis of the bioactive constituents and the therapeutic prospects they offer. This review emphasizes the necessity for further exploration and standardization of diverse pollen sources and bioactive compounds that could contribute to the development of innovative therapies.

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Climate change, airborne allergens, and three translational mitigation approaches

Cited by 16 publications

References 84 publications

Molecular Mapping of Allergen Exposome among Different Atopic Phenotypes

Molecular Mapping of Allergen Exposome among Different Atopic Phenotypes

Air pollution and rhinitis

Chemical Properties and Biological Activity of Bee Pollen

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