2019
DOI: 10.1007/s10787-019-00670-w
|View full text |Cite
|
Sign up to set email alerts
|

Clindamycin inhibits nociceptive response by reducing tumor necrosis factor-α and CXCL-1 production and activating opioidergic mechanisms

Abstract: Clindamycin, a bacteriostatic semisynthetic lincosamide, is useful in the management of infections caused by aerobic and anaerobic Gram-positive cocci, including bacteremic pneumonia, streptococcal toxic shock syndrome and sepsis. It has been recently demonstrated that clindamycin inhibits in vitro and in vivo inflammatory cytokine production. In the present study, we investigated the effects of clindamycin in acute and chronic models of pain and inflammation in mice and the underlying mechanisms. Intraperiton… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
4
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 6 publications
(4 citation statements)
references
References 75 publications
0
4
0
Order By: Relevance
“…Moreover, it can also lead to the movement of neutrophils, interfere with the function of gastric mucosal endothelial cells and cause gastric mucosal damage (44). TNF receptor can transmit survival and death signals to cells, which plays an important role in cell proliferation, differentiation, apoptosis, regulation of immune response, and induction of inflammation (45).…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, it can also lead to the movement of neutrophils, interfere with the function of gastric mucosal endothelial cells and cause gastric mucosal damage (44). TNF receptor can transmit survival and death signals to cells, which plays an important role in cell proliferation, differentiation, apoptosis, regulation of immune response, and induction of inflammation (45).…”
Section: Discussionmentioning
confidence: 99%
“…Antibiotics aid the immune system in battling infection and subsequently dismiss the cause of inflammation and pain; however, some studies [ 30 , 31 ] state that such an action may be attributed to non-microbial activity. Although the antimicrobial effect of clindamycin is indisputable, some studies [ 32 , 33 ] have demonstrated that clindamycin may inhibit the production of tumor necrosis factor-alpha (TNFα), interleukin-1(IL-1), and cytokines. Therefore, its non-antimicrobial immunomodulatory influence should be emphasized.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, clindamycin suppresses the release of proinflammatory cytokines, such as TNF-α and IL-1β, that cause further destruction to the periodontal tissues when released in excess by bacteria and neighboring cells. Thus, the reduced production of TNF-α and chemokine CXCL-1 is another mechanism mediating the clindamycin inhibitory effect on inflammatory conditions such as periodontitis [6].…”
Section: Clindamycin and Its Mechanisms Of Actionmentioning
confidence: 99%
“…It can also be administered intravenously and has a remarkable tissue distribution and increased efficiency for S. aureus infections [5]. Furthermore, clindamycin has been suggested to exert immunomodulatory properties due to the suppression of proinflammatory cytokine release and its effects on phagocyte function, which is considered superior to dexamethasone with regard to Porphyromonas gingivalis [6,7]. Finally, clindamycin induces morphological changes at the surface of bacteria to facilitate their destruction and stimulates chemotaxis, thus inducing the mobilization of polymorphonuclear leukocytes at the site of infection and bacteria phagocytosis [8].…”
Section: Introductionmentioning
confidence: 99%