Clinic and semiotics of digestive lesions with coronavirus SARS-CoV-2

Kucherenko, N. G.; Ratnikova, A. K.; Гриневич, В. Б.; Ткаченко, Е. И.; Kravchuk, Yu. A.

doi:10.31146/1682-8658-ecg-186-2-20-26

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…Так, согласно дынным клинических исследований, распространенность жалоб со стороны желудочно-кишечного тракта (ЖКТ) сильно варьирует -они регистрируются от 3% до 80% пациентов с COVID-19 [3]. Основные гастроинтестинальные проявления COVID-19 у пациентов включают в себя диарею, тошноту, рвоту, анорексию, боль в животе, изменение или потерю вкусовой чувствительности [4][5][6][7].…”

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Some clinical and pathogenetic aspects of irritable bowel syndrome in patients who have undergone COVID-19

Nalyotov,

Shapchenko,

Guz

2024

jour

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One of the manifestations of COVID-19 are complaints from the gastrointestinal tract, the frequency of which ranges from 3% to 80% of patients. The article presents up-to-date data on the pathogenesis of irritable bowel syndrome and features of the clinical picture of this disorder in patients who have undergone COVID-19. The influence of SARS-Cov-2 on the main pathogenetic links of irritable bowel syndrome is indicated. The problem of gastrointestinal tract damage in COVID-19 has not been fully studied and remains no less relevant for the occurrence of pathological processes in the respiratory tract.

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Some clinical and pathogenetic aspects of irritable bowel syndrome in patients who have undergone COVID-19

Nalyotov,

Shapchenko,

Guz

2024

jour

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Diseases of the digestive organs and COVID-19

Гриневич

Kravchuk

2021

Russian Military Medical Academy Reports

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With a new coronavirus infection (COVID-19), gastroenterological symptoms are often detected, which is due to both the damage to the digestive organs by the SARS-CoV-2 coronavirus and the exacerbation of chronic diseases, as well as aggressive multicomponent therapy. The severity of gastroenterological manifestations, primarily impaired liver function, is associated with a more severe and complicated course of COVID-19 infection. Numerous mechanisms of damage to the digestive organs in COVID-19 have been identified: direct damage by the virus due to resuscitation and multicomponent therapy, impaired central and peripheral nervous regulation, immunothrombotic syndrome, virus persistence in the gastrointestinal tract, induction of autoimmune reactions by the virus, humoral disorders (changes in serotonin levels, bradykinin, activation of mast cells). Violation of the microbial-tissue complex of the intestine and the permeability of the intestinal barrier, induced by the SARS-CoV-2 virus, ensures the formation and progression of chronic systemic inflammation, cytokine aggression, insulin resistance, endothelial dysfunction, which affect the severity of the infection. Therapy for patients with COVID-19 should include therapeutic approaches aimed at correcting disorders of the intestinal microbiota, intestinal barrier permeability, and relief of gastroenterological manifestations (bibliography: 20 refs).

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The duration of gastrointestinal symptom persistence at various periods of coronavirus infection

Sadretdinova

Gantseva

Galina

et al. 2023

Almanac of Clinical Medicine

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Aim: To analyze prevalence and type of symptomatic gastrointestinal involvement during symptomatic COVID-19 (up to 412 weeks after the disease) and post-COVID-19 syndrome (more than 12 weeks from the disease onset). Materials and methods: We retrospectively analyzed the data from 785 in-patients with the diagnosis of COVID-19, who were treated in the infectious disease hospital from May to December 2020. At the first phase of the study we analyzed how frequently they were referred for out-patient care by a gastroenterology specialist after they were discharged from the hospital (all 785 patient medical files). At the 2nd study phase we performed phone calls to 247 patients, that were discharged from the infectious disease hospital, during which a specially designed questionnaire was filled with items on their comorbidities, general and specific complaints, as well as the standardized Gastrointestinal Symptom Rating Scale (GSRS). Results: Within 2 years after their discharge from the infectious disease hospital, 88 patients asked for specialized gastroenterological care on an out-patient basis. The most common diagnoses were pancreatic diseases (33%), gastric disorders (31%), intestinal disorders (25%), liver and biliary disorders (11%). At referral, the most common complaints were dyspeptic: nausea, bitter taste in the mouth, heartburn, bloating (25%), abdominal pains of various location (17%) and stool abnormalities, such as diarrhea and constipation (11%). Among patients who participated in the phone survey (N = 247), symptomatic COVID-19 was observed in 90 (11.46%) cases, with predominant complaints being loss of taste, loss of smell, and fever. Post-COVID-19 syndrome was identified in 157 (20%) cases, with their main complaints being weakness, shortness of breath and joint pain. Stool abnormalities and abdominal pain occurred during symptomatic COVID-19 and in the post-COVID-19 period with the same frequency (9% and 10%, respectively). According to the GSRS results, the post-COVID-19 dyspeptic syndrome was characterized by prevailing complaints of heartburn (24%), upper abdominal pain and discomfort (20%), and bloating (15%). Conclusion: In the patients with a history of COVID-19, along with respiratory syndromes, gastrointestinal symptoms are seen, with their types being variable at various period of the coronavirus infection. In the early COVID-19, these are stool abnormalities and abdominal pain, and during the post-COVID-19 syndrome, nausea, bitter taste in the mouth, heartburn and bloating are more common.

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Clinic and semiotics of digestive lesions with coronavirus SARS-CoV-2

Cited by 4 publications

References 18 publications

Some clinical and pathogenetic aspects of irritable bowel syndrome in patients who have undergone COVID-19

Some clinical and pathogenetic aspects of irritable bowel syndrome in patients who have undergone COVID-19

Diseases of the digestive organs and COVID-19

The duration of gastrointestinal symptom persistence at various periods of coronavirus infection

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