Clinic Pathological Study of Aneurysmal Fibrous Histiocytoma

Abstract

Aneurysmal fibrous histiocytoma (AFH) is a rare variant of benign fibrous histiocytoma (FH), Characterized by blood-filled spaces within the fibrohistiocytic tumor. AFH has a higher recurrence rate than FH. The diagnosis of AFH is often problematic due to its overlapping morphological features with other skin tumors. The diagnosis of AFH depends on histological features and immunohistochemistry. The aim of this study is to understand the clinical and histopathological diagnostic criteria for AFH.

A scalp nodule with a gray purple pattern

“…Immuno-histochemical staining can be helpful in these cases. 6 While the pathogenesis of AFH remains unknown, several authors explained the extravasation of erythrocytes from the vessel walls and the pseudovascular cystic spaces to repeated trauma or microtrauma. 1 The patient in our case had a history of trauma at the site.…”

“…These vascular spaces have no endothelial lining, as it was in our case. 6 Complete surgical resection is accepted as the optimal treatment for AFH. A high risk of local recurrence after incomplete excision with positive tumor margins has been reported.…”

Aneurysmal Fibrous Histiocytoma: A Rare Variant

“…Aneurysmal fibrous histiocytoma (AFH) is a rare variant of benign fibroushistiocytoma (FH), posing diagnostic difficulty due to morphological resemblance to malignant melanoma, angiomatoid fibrous histicytoma, kaposi sarcoma and angiosarcoma. Since AFH has a benign course but higher recurrence rate than FH (1) it is essential to differentiate it from the other close differentials. This tumor accounts for less than 2% of all fibrous histiocytomas, and it is typically known to occur in the extremities of middleaged patients (2)(3) .…”