Clinical analysis of lectin-like oxidized low-density lipoprotein receptor-1 in patients with in-stent restenosis after percutaneous coronary intervention

Liu, Junfeng; Liu, Yunde; Ke, Jia; Huo, Zhixiao; Huo, Qianyu; Liu, Zhili; Li, Yongshu; Han, Xuejing; Wang, Rong

doi:10.1097/md.0000000000010366

Cited by 9 publications

(5 citation statements)

References 36 publications

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“…To the best of our knowledge, this association in OSA patients has not been studied previously. The correlation between LOX-1 and uric acid was described in healthy men [33] and in patients with coronary artery disease [34]. In vitro study show, that xanthine oxidase, which catalyzes the oxidation of xanthine to uric acid, stimulates LOX-1 expression on macrophages and vascular smooth muscle cells and induces foam cell formation through LOX-1 [35].…”

Section: Discussionmentioning

confidence: 99%

Endothelin-1 and LOX-1 as Markers of Endothelial Dysfunction in Obstructive Sleep Apnea Patients

Kosacka

Brzecka

2021

IJERPH

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Introduction: The search of biochemical markers of endothelial dysfunction: lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1)—involved in atherosclerotic plaques formation—and endothelin-1 (ET-1)—potent vasoconstrictor-might help in detecting obstructive sleep apnea (OSA) patients at high risk of cardiovascular diseases. Material and Methods: In 71 OSA patients (apnoea/hypopnoea index, AHI 28.2 ± 17.9/hour) and in 21 healthy controls the serum levels of LOX-1 and ET-1 were measured. Results: There were increased levels of ET-1 (1.58 ± 0.65 vs. 1.09 ± 0.38 pg/mL; p < 0.001) but not of LOX-1 in OSA patients as compared with healthy controls. In the patients’ group ET-1 levels negatively correlated with serum LDL levels. LOX-1 levels positively correlated with fasting glucose levels and were higher in the patients with than without diabetes. Neither ET-1 nor LOX-1 correlated with OSA severity. In mild OSA patients, there was a negative correlation between LOX-1 and mean arterial oxygen saturation during sleep. In severe OSA patients, there was a positive correlation between LOX-1 levels and uric acid. Conclusion: There is endothelial dysfunction in OSA patients as indicated by increased serum levels of ET-1 and possibly endothelial dysfunction in diabetic OSA patients as indicated by increased serum levels of LOX-1 and its correlation with fasting glucose levels.

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Section: Discussionmentioning

confidence: 99%

Endothelin-1 and LOX-1 as Markers of Endothelial Dysfunction in Obstructive Sleep Apnea Patients

Kosacka

Brzecka

2021

IJERPH

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“…Since the introduction of percutaneous transluminal coronary angioplasty (PTCA) in 1977, restenosis, which has an occurrence rate of 32%–40% at 6 months after PTCA, has hampered the long‐term efficacy of PTCA. 2 , 17 Use of drug‐eluting stents (DES), which are coated with antiproliferative drugs, such as sirolimus or paclitaxel, has dramatically reduced the occurrence rate of ISR. 18 However, despite the use of dual antiplatelet and intensive statins therapy, the incidence of ISR after PCI remains high.…”

Section: Discussionmentioning

confidence: 99%

Value of M2BP in predicting in‐stent restenosis in patients after coronary drug‐eluting stent implantation

Yang

Zhu

Sun

et al. 2022

Clinical Cardiology

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Objective We evaluated the association between plasma levels of mac‐2 binding protein (M2BP) with the risk of in‐stent restenosis (ISR) after percutaneous coronary intervention (PCI). Methods Plasma M2BP levels were compared between 258 patients who experienced ISR at 12‐months post‐PCI and 258 patients, matched for age and sex, without angiographic evidence of ISR. Results The plasma M2BP level was significantly higher in the ISR than in the non‐ISR group. On multivariate analysis, adjusted for potential clinical, biochemical, and angiography characteristics, M2BP remained as an independent significant predictor of ISR. Conclusions M2BP may be an important predictive biomarker of ISR and may be useful in identifying at‐risk patients.

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“…CAG examination is the “criterion standard” for the judgment of coronary restenosis after PCI, but CAG is an invasive examination and the compliance of patients is low. [ 26 , 27 ] Cardiovascular clinical attention is focused on finding serum markers that can effectively and easily reflect coronary restenosis after PCI. Therefore, some researchers have suggested that the detection of serum inflammatory markers may be more effective in predicting coronary restenosis after PCI.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of inflammatory factors on coronary restenosis after percutaneous coronary intervention in patients with coronary heart disease

Chu¹,

Wang²,

Song³

et al. 2021

Medicine

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Background Evidence reveals that inflammatory factors can predict coronary restenosis in patients suffering from coronary heart disease (CHD) after percutaneous coronary intervention (PCI). Perhaps, inflammatory factors are promising biomarkers for the diagnosis of coronary restenosis after PCI. However, the accuracy of inflammatory factors has not been systematically evaluated. Therefore, it is necessary to perform a meta-analysis to certify the diagnostic values of inflammatory factors on coronary restenosis after PCI. Methods China National Knowledge Infrastructure (CNKI), Wanfang, VIP, China Biology Medicine disc (CBM), PubMed, EMBASE, Cochrane Library and Web of Science were searched for relevant studies to explore the potential diagnostic values of inflammatory factors on coronary restenosis after PCI from inception to January 2021. All data were extracted by 2 experienced researchers independently. The risk of bias about the meta-analysis was confirmed by the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). The data extracted were synthesized and heterogeneity was investigated as well. All of the above statistical analyses were carried out with Stata 16.0. Results The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. Conclusion This study clarified confusions about the specificity and sensitivity of inflammatory factors on coronary restenosis after PCI, thus further guiding their promotion and application. Ethics and dissemination Ethical approval will not be necessary since this systematic review and meta-analysis will not contain any private information of participants or violate their human rights. Trial Registration Number: DOI 10.17605/OSF.IO/N28JX.

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Clinical analysis of lectin-like oxidized low-density lipoprotein receptor-1 in patients with in-stent restenosis after percutaneous coronary intervention

Abstract: Supplemental Digital Content is available in the text

Cited by 9 publications

References 36 publications

Endothelin-1 and LOX-1 as Markers of Endothelial Dysfunction in Obstructive Sleep Apnea Patients

Endothelin-1 and LOX-1 as Markers of Endothelial Dysfunction in Obstructive Sleep Apnea Patients

Value of M2BP in predicting in‐stent restenosis in patients after coronary drug‐eluting stent implantation

Predictive value of inflammatory factors on coronary restenosis after percutaneous coronary intervention in patients with coronary heart disease

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