Clinical and anatomical heterogeneity in autistic spectrum disorder: a structural MRI study

Toal, Fiona; Daly, Eileen; Page, Lisa; Deeley, Quinton; Hallahan, Brian; Bloemen, Oswald; Cutter, William; Brammer, Michael; Curran, Sarah; Robertson, Dene; Murphy, Clodagh; Murphy, Kieran C.; Murphy, Declan

doi:10.1017/s0033291709991541

Cited by 109 publications

(117 citation statements)

References 62 publications

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“…This is in accord with many previous VBM studies (Abell et al 1999;Boddaert et al 2004;Brieber et al 2007;Salmond et al 2007;Ke et al 2009;Dziobek et al 2010;Kosaka et al 2010;Toal et al 2010;Riva et al 2011;Via et al 2011;Yu et al 2011). However, other studies have found gray matter increases in some of these and other regions in ASD, making the current picture on structural brain differences in ASD somewhat inconsistent (Amaral et al 2008).…”

Section: Regional Gray Matter Abnormalities and Their Correlation Witsupporting

confidence: 87%

“…Interestingly, morphological changes such as reduced gray matter volume have been reported in ASD in both these regions (Boddaert et al 2004;Brieber et al 2007;Salmond et al 2007;Ke et al 2009;Toal et al 2010;Via et al 2011;Yu et al 2011). The question arises whether the variation of social behavior deficits and of other behavioral aspects of ASD can be related to the morphology of brain regions associated with the disorder.…”

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confidence: 99%

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Right Temporoparietal Gray Matter Predicts Accuracy of Social Perception in the Autism Spectrum

David

Schultz

Milne

et al. 2013

J Autism Dev Disord

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Individuals with an autism spectrum disorder (ASD) show hallmark deficits in social perception. These difficulties might also reflect fundamental deficits in integrating visual signals. We contrasted predictions of a social perception and a spatialndash;temporal integration deficit account. Participants with ASD and matched controls performed two tasks: the first required spatiotemporal integration of global motion signals without social meaning, the second required processing of socially relevant local motion. The ASD group only showed differences to controls in social motion evaluation. In addition, gray matter volume in the temporalndash;parietal junction correlated positively with accuracy in social motion perception in the ASD group. Our findings suggest that socialndash;perceptual difficulties in ASD cannot be reduced to deficits in spatialndash;temporal integration

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Section: Regional Gray Matter Abnormalities and Their Correlation Witsupporting

confidence: 87%

mentioning

confidence: 99%

Right Temporoparietal Gray Matter Predicts Accuracy of Social Perception in the Autism Spectrum

David

Schultz

Milne

et al. 2013

J Autism Dev Disord

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“…On the other hand, the sparse literature on CC volume in low-functioning ASD (Riva et al 2011) prevents us from drawing inferences about the influence of IQ on CC volume and calls for further investigation. Only a relatively few studies did not reveal significant CC volume differences between ASD patients and typically developing controls; in particular, this finding has been reported more often in voxel-based morphometry (Waiter et al 2004;Bonilha et al 2008;Ke et al 2008;Ecker et al 2010;Toal et al 2010;Cheng et al 2011;Mengotti et al 2011;Calderoni et al 2012) than in region of interest-based (Hong et al 2011) analyses. Notably, to our knowledge, there have been no published studies reporting volumetric increase of CC (Table 1).…”

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confidence: 92%

Brain anatomy of autism spectrum disorders I. Focus on corpus callosum

Bellani

Calderoni

Muratori

et al. 2013

Epidemiol Psychiatr Sci

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This Section of Epidemiology and Psychiatric Sciences regularly appears in each issue of the Journal to describe relevant studies investigating the relationship between neurobiology and psychosocial psychiatry in major psychoses. The aim of these Editorials is to provide a better understanding of the neural basis of psychopathology and clinical features of these disorders, in order to raise new perspectives in every-day clinical practice. This brief review aims to examine the structural magnetic resonance imaging (sMRI) studies on corpus callosum in autism spectrum disorders (ASD) and discuss the clinical and demographic factors involved in the interpretation of results.

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“…Investigaciones posteriores señalaron resultados similares en adolescentes y adultos con este síndrome (O'Brien et al, 2010;Murphy et al, 2012). Sin embargo, Toal et al (2010) y Yu et al observaron reducción de la sustancia gris en hipocampos de individuos adultos con SA en comparación con los controles.…”

Section: Características Neuroanatómicasunclassified

Características Neuroanatómicas del Síndrome de Asperger

Vásquez

Sol

2017

Int. J. Morphol.

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VÁSQUEZ, B. & DEL SOL, M.Características neuroanatómicas del Síndrome de Asperger. Int. J. Morphol., 35(1):376-385, 2017. RESUMEN:El síndrome de Asperger (SA) es un trastorno del neurodesarrollo que se caracteriza por presentar deterioros cualitativos de las interacciones sociales recíprocas y de los modos de comunicación, como también por la restricción del repertorio de intereses y de actividades que se aprecian estereotipadas y repetitivas. En la actualidad, el Manual Diagnóstico y Estadístico de Trastornos Mentales (DSM-V) decide eliminar esta subcategoría e incorporarla en una categoría general conocida como trastorno del espectro autista (TEA), lo que ha producido muchos debates y desacuerdos principalmente por distingirlo o no, con el autismo del alto funcionamiento (AAF). Un enfoque para resolver esta cuestión corresponde a los esfuerzos que se realizan por comprender la neuroanatomía estructural y funcional del TEA y del SA en particular, sin embargo, estas aproximaciones han dado lugar a resultados variables, debido a las diferencias en la edad, género, subcategorías y coefieciente intelectual de los sujetos de estudio, así como por criterios de inclusión y metodología de estudio. En base a lo anterior, el objetivo de esta revisión fue exponer el conocimiento actual de las características neuroanatómicas del SA considerando para esto aquellas investigaciones del TEA que individualizan este trastorno como entidad diagnóstica y lo diferencian del AAF.

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Clinical and anatomical heterogeneity in autistic spectrum disorder: a structural MRI study

Abstract: Adults with ASD have significant differences from controls in the anatomy of brain regions implicated in behaviours characterizing the disorder, and this differs according to clinical subtype.

Cited by 109 publications

References 62 publications

Right Temporoparietal Gray Matter Predicts Accuracy of Social Perception in the Autism Spectrum

Right Temporoparietal Gray Matter Predicts Accuracy of Social Perception in the Autism Spectrum

Brain anatomy of autism spectrum disorders I. Focus on corpus callosum

Características Neuroanatómicas del Síndrome de Asperger

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