Clinical and Bacteriological Characteristics of Neonatal Sepsis in an Intensive Care Unit in Kashan, Iran: A 2 Year Descriptive Study

Mosayebi, Ziba; Movahedian, A H; Soori, Tahereh

doi:10.5812/pedinfect.7875

Cited by 9 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, respiratory distress was more common in EOS while jaundice, fever and seizure were associated with LOS. Respiratory distress and poor feeding were the most common signs reported in various studies (2,14). It is presumed that there is an association between poor feeding and jaundice as common presentations of LOS.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Assessing the Role of Clinical Manifestations and Laboratory Findings in Neonatal Sepsis

Hematyar

Najibpour

Bayesh

et al. 2016

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

Background: Neonatal sepsis is one of the major causes of morbidity and mortality in newborns. Since early diagnosis of neonatal septicemia is important for timely initiation of correct antimicrobial therapy and considering the existence of variability in nonspecific clinical laboratories, we assessed the role of clinical manifestations and laboratory findings to find the right diagnosis. Objectives: The aim of this study was to evaluate, record and rank the clinical manifestations and lab data of neonates with clinical sepsis. Methods: In a cross sectional descriptive prospective study in 2013, a total of 110 consecutive infants with clinical manifestations of sepsis were studied in two groups including early onset sepsis (EOS) taking place at 72 hours of age or younger, and late onset sepsis (LOS) occurring after 72 hours. Check list of infant's data, presenting symptoms or signs and laboratory data in both groups were evaluated and recorded. Significant differences were set at as P < 0.05. Results: Overall, 81.8% of infants had EOS while 18.2% of infants had LOS. The mean age at the time of EOS and LOS presentation was one to two days and four to twelve days, respectively. The most common clinical manifestations were respiratory distress in 49 (44.5%), jaundice in 28 (25.5%), vomiting in 26 (23.6%) and poor feeding in 23 (20.9%) of the infants. Other clinical manifestations were lethargy (weakness), decreased sucking reflex, fever, tremor, abdominal distention and seizure, found in 12 (10.9%), 10 (9.1%), 4 (3.6%), 4 (3.6%), 3 (2.7%) and 2 (1.8%) neonates, respectively. Early Onset Sepsis was considerably associated with respiratory distress (P < 0.001), while LOS in neonates was followed by jaundice (P < 0.001), seizure (P = 0.02) and fever (P < 0.001). Anemia, leukocytopenia, leukocytosis, thrombocytopenia and C-reactive protein (CRP) positive results and blood culture was detected in 36 (32.7%), 2 (1.8%), 0 (0%), 2 (1.8%), 19 (17.3%) and 110 (100 %) neonates, respectively. Cerebrospinal Fluid (CSF) cultures were negative in all infants. Positive urine culture was seen in 10 (9.1%) infants. Conclusions: Respiratory distress is more common in EOS whereas jaundice, fever and seizure are more likely to be observed in LOS infants. Considering the results, clinical manifestations should be regarded as an important part of early diagnosis of sepsis.

show abstract

Section: Discussionmentioning

confidence: 95%

“…Neonatal sepsis causes high morbidity and mortality of newborns (1,2). The world health organization (WHO) has estimated four million neonate deaths in the first four weeks of life, in which one million of them is allocated to neonatal sepsis with occurrence of 42% in the first week of life (3,4).…”

Section: Introductionmentioning

confidence: 99%

Assessing the Role of Clinical Manifestations and Laboratory Findings in Neonatal Sepsis

Hematyar

Najibpour

Bayesh

et al. 2016

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

show abstract

“…ganism from blood cultures was Flavobacterium (22). The extensive use of invasive devices to care for immunologically-immature neonates, especially preterm and low birth weight (LBW), is the main cause of CoNS bacteremia in NICU; determination of the identity of CoNS isolates whether being true pathogens or contaminants is still problematic (16).…”

mentioning

confidence: 99%

Prevalence and Antibiotic Resistance of Neonatal Sepsis Pathogens in Neyshabour, Iran

Behmadi

Borji

Taghavi-Rad

et al. 2016

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

Background: Neonatal sepsis is a systemic inflammatory response syndrome that is secondary to infection. It is a major cause of neonatal mortality in the world, particularly in developing countries. A definitive diagnosis requires the isolation of pathogens from a normally sterile body site, including blood, cerebrospinal fluid and urine. Empirical antibiotic therapy is based on the physician's knowledge of the anticipated bacterial species and their expected antibiotic susceptibilities. Objectives: The aim of this study was to determine the prevalence and evaluate the antimicrobial susceptibility patterns of bacterial infections at a neonatal unit. Patients and Methods:This study was conducted at the neonatal intensive care unit and neonatal ward of Hakim hospital, Neyshabour, Iran. Blood, cerebrospinal fluid (CSF) and urine specimens were collected before institution of empirical antibiotic therapy. Antibiotic resistance pattern of the isolates was studied by the disc diffusion technique. Results: Coagulase-negative staphylococci (CoNS) were the most prevalent pathogens isolated from blood specimens in early and late-onset disease. Escherichia coli and Klebsiella were the most causative pathogens in early and late-onset urinary tract infections. They had high resistance to our empirical antibiotic regimens. Prevalence of bacterial meningitis was low in our study. Conclusions: Due to the increasing resistance of pathogens to usual empirical antibiotics, it is reasonable to stress upon preventive measures, so that a minimum number of neonates develop sepsis.

show abstract

“…Shamsizadeh Hayat Davodi et al (2008) and Gheibi et al (2005) reported coagulase-negative staphylococcus . Mosayebi (2013) reported Flavobacterium that is an uncommon agent for nosocomial infection, the most common cause of neonatal sepsis in an intensive care unit in Kashan.…”

Section: Discussionmentioning

confidence: 99%

Clinical Findings Leading to the Diagnosis of Sepsis in Neonates Hospitalized in Imam Khomeini and Bu Ali Hospitals, Sari, Iran: 2011-2012

Farhadi¹,

Yaghobian²,

Saravi³

2014

GJHS

View full text Add to dashboard Cite

Background:One of the important diseases in neonatal period is sepsis. Clinical sign and symptoms in addition to lab tests are the most important way to accurate diagnosis and prevention of mortality. This study was conducted with the aim of determining the most clinical sign and symptoms which leading to diagnosis of sepsis.Materials and Methods:This is a descriptive cross-sectional study. The medical records of patients hospitalized in hospitals of Mazandaran University of Medical Sciences during 2011-2012 were reviewed. Variables were age, sex, birth and admission weight, clinical sign and symptoms, methods of delivery, admission and discharge condition, discharge status, the time elapsed between showing the symptom and admission to hospital, gestational age and the result of cultures. The data were recorded in a checklist and analyzed with SPSS and descriptive statistics.Results:finding showed that 120 patients discharged during period of study with diagnosis of sepsis. Discharged status of 27 (%22/5) were expired. Median age was 1 day with 8 hours SD, length of stay were 12±1 days, gestational age was 34±3 weeks and median birth weight was 2477±977 grams. The median time elapsed between showing the symptom and admission to hospital was 38±31 hours. Blood culture in 10 (%8/3) and urine culture in 8 (%7/6) patients were positive. None of patients have positive lumbar puncture culture. The frequent sign and symptpms in patients were respiratory distress, poor feeding and lethargy.Conclusion:Early diagnosis of neonatal sepsis is not possible only by specific laboratory exams. Clinical sign and symptoms can help us to prediction and diagnosis of neonatal sepsis. Results of this research revealed that it is not clear which one of manifestations was started first or the second because of medical history sheets don’t show this process.

show abstract

Clinical and Bacteriological Characteristics of Neonatal Sepsis in an Intensive Care Unit in Kashan, Iran: A 2 Year Descriptive Study

Cited by 9 publications

References 17 publications

Assessing the Role of Clinical Manifestations and Laboratory Findings in Neonatal Sepsis

Assessing the Role of Clinical Manifestations and Laboratory Findings in Neonatal Sepsis

Prevalence and Antibiotic Resistance of Neonatal Sepsis Pathogens in Neyshabour, Iran

Clinical Findings Leading to the Diagnosis of Sepsis in Neonates Hospitalized in Imam Khomeini and Bu Ali Hospitals, Sari, Iran: 2011-2012

Contact Info

Product

Resources

About