Clinical and biochemical findings in ten patients with benign myalgic encephalomyelitis

Ramsay, A. Melvin; Rundle, A. T.

doi:10.1136/pgmj.55.650.856

Cited by 11 publications

(2 citation statements)

References 3 publications

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“…However, specific mechanisms are involved in FM which 1) increase Pyr in contrast to glycogenosis [10], chronic pain [5], and benign myalgic encephalomyelitis [22], and 2) decrease L in contrast to mitochondrial my opathies and hypoxic conditions usually associated with a marked rise of L [23]. Moreover, FM can be differentiated from thyroid dysfunction by normal GAPDH activity and pH recuperation [8] in exercising muscle, both of which are impaired in HO [12,13].…”

Section: Discussionmentioning

confidence: 99%

Glycolysis abnormalities in fibromyalgia.

Eisinger

Plantamura

Ayavou

1994

Journal of the American College of Nutrition

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Section: Discussionmentioning

confidence: 99%

Glycolysis abnormalities in fibromyalgia.

Eisinger

Plantamura

Ayavou

1994

Journal of the American College of Nutrition

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“…A study of 10 Class B patients detected elevated serum levels of myoglobin in 8, of gamma glutamyl transpeptidase (GGTP) in 3, of glutamic-oxaloacetic transaminase (SGOT) in 10, and of glutamic-pyruvic transaminase (SGPT) in 4. Studies in 5 of these patients detected normal levels of serum pyruvate and adenosine triphosphate (ATP) in all 5 patients, and of serum lactate in 4 (Ramsay and Rundle 1979). Excessive acidosis has been detected in skeletal muscle cells following exertion in 1 Class B patient , and slightly subnormal state III respiration rates in isolated mitochondria have been detected in 2 Class B patients .…”

Section: Skeletal Muscle Studiesmentioning

confidence: 98%

Infectious Mononucleosis

1989

Clinical Topics in Infectious Disease

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Infectious mononucleosis is a clinical entity characterized by pharyngitis, cervical lymph node enlargement, fatigue and fever, which results most often from a primary Epstein-Barr virus (EBV) infection. EBV, a lymphocrytovirus and a member of the γ-herpesvirus family, infects at least 90% of the population worldwide, the majority of whom have no recognizable illness. The virus is spread by intimate oral contact among adolescents, but how preadolescents acquire the virus is not known. During the incubation period of approximately 6 weeks, viral replication first occurs in the oropharynx followed by viremia as early as 2 weeks before onset of illness. The acute illness is marked by high viral loads in both the oral cavity and blood accompanied by the production of immunoglobulin M antibodies against EBV viral capsid antigen and an extraordinary expansion of CD8 + T lymphocytes directed against EBV-infected B cells. During convalescence, CD8 + T cells return to normal levels and antibodies develop against EBV nuclear antigen-1. A typical clinical picture in an adolescent or young adult with a positive heterophile test is usually sufficient to make the diagnosis of infectious mononucleosis, but heterophile antibodies are not specific and do not develop in some patients especially young children. EBV-specific antibody profiles are the best choice for staging EBV infection. In addition to causing acute illness, long-term consequences are linked to infectious mononucleosis, especially Hodgkin lymphoma and multiple sclerosis. There is no licensed vaccine for prevention and no specific approved treatment. Future research goals are development of an EBV vaccine, understanding the risk factors for severity of the acute illness and likelihood of developing cancer or autoimmune diseases, and discovering anti-EBV drugs to treat infectious mononucleosis and other EBV-spurred diseases.

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The Chronic Fatigue Syndrome

Holmes¹

1989

Clinical Topics in Infectious Disease

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Clinical and biochemical findings in ten patients with benign myalgic encephalomyelitis

Cited by 11 publications

References 3 publications

Glycolysis abnormalities in fibromyalgia.

Glycolysis abnormalities in fibromyalgia.

Infectious Mononucleosis

The Chronic Fatigue Syndrome

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