Clinical and Biological Factors Associated with Treatment Outcome of Cerebral Malaria in Children under Five in Yaounde

Monebenimp, Francisca; Bisong, Calvin Ebai; Chiabi, Andréas; Chelo, David; Moyo-Somo, Roger

doi:10.4303/jnp/n100506

Cited by 2 publications

(1 citation statement)

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“…The age distribution of the children with CM in this study is similar to what has been found in previous studies where the incidence of CM was found to be higher in children below 5 years. [394041424344] The age group with the highest incidence of CM in this study (13–24 months) is also similar to previous findings. [414244] This is the period when children are most susceptible to infections, especially severe forms of malaria.…”

Section: Discussionsupporting

confidence: 91%

Plasma and cerebrospinal fluid beta-endorphin levels show a strong association in children with cerebral malaria

et al. 2018

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Background:Beta (β)-endorphins are endogenous neuropeptides found in the plasma and cerebrospinal fluid (CSF) of humans but there have been reports of the relationship between the plasma and CSF β-endorphin levels in different clinical conditions. However, the relationship between β-endorphin levels in the plasma and CSF of children with cerebral malaria (CM) has not been reported.Aim:To determine the relationship between β-endorphin levels in the CSF and plasma of children with CM.Settings and Design:This cross-sectional study involved 40 children, aged between 6 months and 14 years, admitted with a diagnosis of CM at the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Nigeria.Materials and Methods:One milliliter (mL) of venous blood and 1mL of CSF obtained from each subject at admission were used to determine the β-endorphin levels using enzyme-linked immunosorbent assay (ELISA) method.Statistical Analysis:Bivariate linear regression was used to determine the association between plasma and CSF β-endorphin levels using the correlation coefficient (r), coefficient of determination (R2), and P values.Results:The plasma β-endorphin levels significantly positively correlated with CSF β-endorphin (r = 0.568, P = 0.001) such that for every unit rise in plasma β-endorphin, CSF β-endorphin rose by 0.252 pmol/L (confidence interval: 0.132–0.371 pmol/L).Conclusion:The finding of positive correlation between plasma and CSF β-endorphin levels in this study suggests a possible direct link between plasma and CSF in CM, probably from the disruption of the blood–brain barrier that has been reported in CM.

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