Status of Selected Hematological and Biochemical Parameters in Malaria and Malaria-typhoid Co-infection

Kayode, Omowumi Titilola; Kayode, Abolanle A.A.; Awonuga, Olalekan

doi:10.3923/jbs.2011.367.373

Cited by 27 publications

(34 citation statements)

References 7 publications

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“…Statistically Significant difference between the values of hemoglobin and pack cell volume obtained among those with malaria and the co-infection shows that presence of the coinfection suppressed the effects of Plasmodium parasites on red blood cells. Lower levels of heamoglobin and pack cell obtained in this study are in agreement with several studies (Taha, 2007;Eze, 2009;Etang, 2010;George, 2011;Kayode, 2011;Shamin, 2012;Akanninwor, 2013) on the effect of malaria on hematological parameters. Though there is no significant difference between the groups, the mean white blood cell counts in both Malaria, control and the co-infection are relatively the same higher than what was obtained among those with HBV infection.…”

Section: Discussionsupporting

confidence: 92%

“…Changes in hematological parameters in malaria infection and HBV infection have been studied by various researchers (Kayode, 2011;George, 2001;Akaninwor, 2013) but there are little or no findings as for the changes in co-infection of Malaria and HBV. These two infections are both endemic in this part of the world and both represent a key threat to humanity.…”

Section: Discussionmentioning

confidence: 99%

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Malaria and Hepatitis B co-infection in patients with febrile illnesses attending general outpatient unit of the Murtala Muhammed Specialist Hospital, Kano, Northwest Nigeria

Dabo¹,

Sharif²,

Muhammed³

et al. 2015

Bayero J. Pure App. Sci.

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Malaria and Hepatitis B Virus (HBV) infections are co-endemic throughout much of the tropical and sub-Saharan Africa and both present major threat to public health. A study on the prevalence of HBV and Malaria co-infection was carried out on 200 patients presenting with fever at the General Outpatient Department (GOPD) of the Murtala Muhammed Specialist Hospital (MMSH), Kano using Gold Standard microscopy and rapid diagnostic test (RDT). The effect of mono and co-infection on hematological parameters was also investigated. Fifty one (25.5%) out of the 200 patients studied were Malaria positive. Females had higher prevalence rate(18%) of Malaria infection than males with 7.5%. Age group 15-24 had the highest Malaria prevalence (11%) followed by age group 25-34 with 6.5%. Higher mean parasite density (1,200/µl) was recorded among subjects with monoinfection of Malaria than mean parasite density (518/µl) obtained among the co-infected. Mean parasite density was higher in female than male subjects. Thirteen (6.5%) subjects were HBV positive. Males had higher rate of infection with 4.5% prevalence than females with 2.0%. Nine individuals representing 4.5% of the total population had co-infection with higher prevalence (3%) among the males. Age groups 25-34 were observed to have high co-infection rate of 1.5% and the least prevalence was observed among the age group 15-24 with 0.5% prevalence for both males and females. Hematological evaluation carried out on all the categories of subjects shows significant difference in mean values of PCV (P=0.041), Hb (P=0.018) between the co-infection group and those with malaria infection and control groups. However, no significant difference (P>0.05) was observed in the values of WBC, PLT and Red cell indices among the co-infected and other test group. It was concluded that co-infection with the two ailments had no profound effect on hematologic parameters.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Malaria and Hepatitis B co-infection in patients with febrile illnesses attending general outpatient unit of the Murtala Muhammed Specialist Hospital, Kano, Northwest Nigeria

Dabo¹,

Sharif²,

Muhammed³

et al. 2015

Bayero J. Pure App. Sci.

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show abstract

“…Contrary to this present study, Kayode et al, 2011 indicated hypoglycemia in both malaria and typhoid co-infected patients. They posited that the level of hypoglycemia correlated with severity of infection, which was elicited by hyper-secretion of insulin [39]. Their report corroborates the studies by Onyesom and Agho 2011, who noted the incidence of hypoglycemia in malaria patients in Edo-Delta state [40].…”

Section: Discussionsupporting

confidence: 72%

Estimation of Stress Induces By Malaria Parasite Infection and Effect of Anti-malaria Drugs on Stress Index, Lipid Profile in Uncomplicated Acute Malaria Infected Adult Individuals

Ayodele¹,

E²

2014

AJCMR

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Malaria infection is accompanied by increased production of reactive oxygen species which indicates the environment for oxidative stress. Oxidative stress in malaria may originate from several sources including intracellular parasitized erythrocytes and extra-erythrocytes as a result of haemolysis and host response. The aim of this study is to estimate level of stress induces by malaria parasite infection and effect of anti malaria drugs on stress index in uncomplicated acute malaria infected adult individuals. 202 confirmed malaria infected patients were recruited for the study between the ages of 15-64 years of both sexes at the general outpatient clinic of the Federal Medical Centre, Ido-Ekiti, Nigeria. 129(63.9%) were males and 73(36.1%) were females. Mean± SD of cortisol, MDA, glucose and HDL in pre anti-malaria drug treatment of age group A were higher compared to other age groups; there is significant difference (p < 0.05) observed in cortisol and glucose. Plasmodium falciparum malaria infection is accompanied by increased production of reactive oxygen species which indicates the environment for oxidative stress. The level of stress induced by malaria parasite is corresponded to the severity of infection and age differences; this could be due to the number of exposure to mosquito bites which increases with age and also increase the level of immunity against malaria infection.

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“…Suppression of hemophagocytosisis responsible for hematological changes [6,28], and the observed low levels of RBC, Hb and PCV were probably caused by inhibition of hematopoiesis which led to anemia. Studies by Dangana and Kayode [29,30] reported decreased levels of PCV in typhoid and paratyphoid patients.The destruction of RBC and decrease in Hb were responsible for the decrease in MCH, MCV and MCHC. Treatment with the ethanolic extract of propolis produced a significant revival of different hematological parameters, such as RBC, Hb, PCV, WBC and neutrophils (p<0.05).Our investigations revealed a significant decrease in the WBC count in group 2 mice as compared to control mice (group 1), suggesting that typhoid leucopenia was caused by invasion of hemopoietic organs, such as the spleen and bone marrow with Salmonella which further slowed down leucopoiesis [31,32].…”

Section: Resultsmentioning

confidence: 99%

Effect of propolis extract on hematotoxicity and histological changes induced by Salmonella enterica serovar Typhimurium in BALB/c mice

Kalia

Kumar

Harjai

2016

ARCH BIOL SCI BELGRA

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Typhoid fever, a life-threatening disease, causes several pathological changes due to the involvement of one or more organs. In the present study, the effect of typhoid on hematological indices and spleen histology in infected mice were investigated. The ameliorative efficacy of the ethanolic extract of propolis was tested and compared with treatment with the typhoid drug,cefixime. BALB/c mice were divided into six groups: group1 was the normal control, group 2 was infected with Salmonella enteric serovar Typhimurium, group 3 was Salmonella infected and treated with cefixime, groups4 and 5 were Salmonella-infected mice treated with 100 mg and 300 mg of propolis respectively. Group 6 was given only 300 mg propolis without infection. Mice were killed after completion of treatment and examination of spleen histology and hematological studies were performed. Significant differences were observed in the propolis-treated group of mice as compared to the infected group without antibiotic, further confirming the ameliorative effect of propolis on Salmonella enterica serovar Typhimurium-induced toxicity in mice.

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Status of Selected Hematological and Biochemical Parameters in Malaria and Malaria-typhoid Co-infection

Cited by 27 publications

References 7 publications

Malaria and Hepatitis B co-infection in patients with febrile illnesses attending general outpatient unit of the Murtala Muhammed Specialist Hospital, Kano, Northwest Nigeria

Malaria and Hepatitis B co-infection in patients with febrile illnesses attending general outpatient unit of the Murtala Muhammed Specialist Hospital, Kano, Northwest Nigeria

Estimation of Stress Induces By Malaria Parasite Infection and Effect of Anti-malaria Drugs on Stress Index, Lipid Profile in Uncomplicated Acute Malaria Infected Adult Individuals

Effect of propolis extract on hematotoxicity and histological changes induced by Salmonella enterica serovar Typhimurium in BALB/c mice

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