Clinical and biological factors predictive of malignancy in dermatomyositis

Abstract

EditorAlthough the paraneoplastic nature of a subset of dermatomyositis (DM) cases is unquestionable, the factors that indicate the coexisting cancer still remain unclear. Several predictive signs have been postulated as a marker of underlying malignancy: older age, male gender, rapid onset of the disease, presence of cutaneous necrosis, increased erythrocyte sedimentation rate (ESR), and increase or normality of creatine phosphokinase (CPK). [1][2][3][4][5][6][7][8] In order to identify potential risk factors for associated cancer in patients with DM, we reviewed clinical and laboratory data of 32 patients with DM (17 females and 15 males, aged 11-78 years), who have been treated during a 23-year period . Diagnosis of DM was based on the criteria of Bohan and Peter. 9 Typical cutaneous signs and muscular involvement (proximal muscle weakness and/or elevated muscle enzymes and/or electromyography findings and/or muscle histology) were observed in all patients. The main recorded data included an association with a cancer, age at the time of the diagnosis, gender, a rapid onset of symptoms (considered if the diagnosis was made within 3 months after the appearance of initial symptoms), signs of severity (presence of dysphonia, dyspnoea and/or dysphagia), some clinical features such as cutaneous necrosis (defined as cutaneous and/or mucosal necrotic lesions or ulcerations) and periungual erythema, evaluated ESR (superior to 40 mm during the first hour), serum muscle enzymes levels -CPK, lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) -as well as presence of antinuclear autoantibodies. Statistical analysis using Fisher's exact test for qualitative data and Mann-Whitney's test for quantitative data were performed to investigate differences between patients with and without associated malignancy. The difference was considered significant at P < 0.05.Malignant tumours were detected in 8 patients (25%), with equal number of female and male patients. Malignancies included colon cancer (2 patients), ovarian cancer (2 patients) and the remaining cancers were those of lung, breast, pancreas and prostate.The prevalence of predicting factors of malignancy is listed in Table 1. Cutaneous necrosis was presenting sign in 76% of our patients with cancer and in only 8.3% of the patients without cancer. Some previously published studies have pointed out that cutaneous necrosis is highly predictive of an associated cancer. 3-6 Including our trial, cutaneous necrosis is thought to increase the probability of occult malignancies in 27 (61%) of cases associated with cancer, opposite to 7 (8%) cases of DM without cancer. Since there is no clear definition for the term 'cutaneous necrosis', as this skin sign comprises a wide range of symptoms, from small digital necrosis to extensive skin and mucosal necrosis, these results, as pointed out by Burnouf et al., 4 must be analysed with reserve.

Factors Predicting Malignancy in Patients with Polymyositis and Dermatomyostis: A Systematic Review and Meta-Analysis

“…Of the included studies, 13 studies[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31] considered age as a variable. Out of these 13 studies, two studies[29], [30] provided age group-specific data: data for patients younger than 45 and data for patients 45 and older.…”

“…A meta-analysis of 11 studies[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [31] indicated that malignancy associated with PM/DM was associated with older age (WMD 10.93, 95% CI: 9.34 to 12.52). For patients with DM only,[19], [20], [21], [22], [23], [24], [25], [31] a similar difference was observed in data pooled from the eight relevant studies (WMD 10.63, 95% CI: 8.92 to 12.33). As noted, two estimates[29], [30] from two studies of PM/DM patients divided the subjects according to age by using “45” as the age divider.…”

“…A total of 16 studies[20], [21], [22], [23], [24], provided data on gender and included a total of 1171 patients (274 males, 23.40%). Findings from this analysis suggest that there was a significant association between male gender and malignancy associated with PM/DM.…”

“…The RR for all studies was 1.78 (95% CI: 1.40 to 2.27). The estimate for the 11[20], [21], [22], [23], [24], [25], [30], [31],[32],[33],[35] of DM patients only was 1.59 (95%CI: 1.12 to 2.25).…”

“…A meta-analysis of the five studies[19], [20], [23], [24], [28] involving cutaneous necrosis indicated that PM/DM patients with cutaneous necrosis faced a significantly higher risk of malignancy (RR, 3.36; 95% CI: 2.04 to 5.52). For patients with DM only,[19], [20], [23], [24] a similar difference was observed in the pooled data of the four relevant studies (RR, 3.95; 95% CI: 2.37 to 6.57).…”