Clinical and Chemical Correlates in Convulsions of the Newborn

Brown, Judson S.; Cockburn, F.; Forfar, J. O.

doi:10.1016/s0140-6736(72)90694-0

Cited by 84 publications

(38 citation statements)

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“…As the child during the first year life. grows, chest wall strength, compliance, and resistance improve, allowing the infant to sustain a high spontaneous minute ventila- (13), and still distress syndrome (RDS) develop bronchopulmonary dysplasia required mechanical ventilation at age 2 months, when they were (BPD) (2,5,8,16). This condition varies from mild, requiring considered eligible for study.…”

Section: Discussionmentioning

confidence: 99%

Improvement in Lung Mechanics as a Function of Age in the Infant with Severe Bronchopulmonary Dysplasia

et al. 1982

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Summarysulted in worsening respiratory failure. The turning point, occurring at a mean age of 7 months, was marked by a significant and Pulmonary function tests were performed in groups of sustained reduction in spontaneous respiratory rate (RR) and infants with bronchO~ulmOnar~ d~s~lasia; a group less than arterial carbon dioxide tension (Pacoz). Subsequently, gradual months of age with severe ventilator-dependent respiratory failure reductions in IMV rate were well tolerated; mean age of weaning (Group A), and a group 7-22 months of age during resolution of from IMV was 14 months. their disease (Group B). Group A patients had significantly eleIt is not known if improvements in pulmonary mechanics vated minute volume, low specific compliance, elevated inspiratory account for this clinically observed improvement in lung function. and expiratory pulmonary resistance, and low functional residual specific pulmonary function abnormalities documented in infants patients IninUte with BPD in the first year of life include high airway resistance whereas ins~iratOr~ pulmonary re-(1, lo), low dynamic compliance (1,3, lo), abnormal lung volumes sistance and functional residual capacity were within normal limits, (3, 22), abnormal gas exchange (3,7,22), and elevated minute and expiratory ~"'m"na'Y resistance was only slightly above ' 0' -volume (10). H~~~~~~, improvement in pulmonary mechanics as ma]. With the exception of minute volume, the differences between a function of age and somatic growth has not been documented. the groups were significant (P < 0.05). Sequential studies of ~r y~~ el al. (3) performed serial measurements of pulmonary resistance and compliance over 4-5 months in two patients in the function during the first year of life in infants with BPD. Eight younger group demonstrated that Or achieved of these patients died in the first year, and the three survivors had normal range. It is concluded that pulmonary mechanics improve persistently increased functional residual capacity (FRC), dewith age in the infant with broncho~u'mona~ d~s~lasia. creased dynamic compliance (CL), hypoxia, and carbon dioxide retention throughout the first year. There is little published data Speculation documenting changes in pulmonary function with age, and no T~~ high minute ventilation demonstrated in children with bran-studies account for the improvement in pulmonary function obchopulmonary dysplasia results from increased dead space ventiserved in Our patients. The purpose this was to lation. With low compliance and high resistance the young infant determine if in pulmonary mechanics Occur in cannot sustain the high minute ventilation required, and respiraassociation with Clinical improvement in ~u l m o n a r~ function tory failure ensues, requiring mechanical ventilation. As the child during the first year life. grows, chest wall strength, compliance, and resistance improve, allowing the infant to sustain a high spontaneous minute ventila- MATERIALS AND METHODS

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Section: Discussionmentioning

confidence: 99%

Improvement in Lung Mechanics as a Function of Age in the Infant with Severe Bronchopulmonary Dysplasia

et al. 1982

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“…Biochemical disturbances occur frequently in neonatal seizures either as an underlying cause or as an associated abnormality. 10,11 Metabolic disturbances could be more commonly transient and rapidly correctable or less commonly inherited as persistent causes.…”

Section: Introductionmentioning

confidence: 99%

Clinical and etiological profile of neonatal seizures: a tertiary care hospital based study

et al. 2015

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“…As many as 20% newborn in intensive care unit may have seizure activity at sometime 4,5 The overall prevalence is as low as 0.5% in term and as high as 21% in preterm babies 6,7 .…”

Section: Introductionmentioning

confidence: 99%