Clinical and Economic Assessment of Diabetic Foot Ulcer Debridement with Collagenase: Results of a Randomized Controlled Study

Tallis, Arthur; Motley, Travis A.; Wunderlich, Robert P.; Dickerson, Jaime E.; Waycaster, Curtis; Slade, Herbert B.

doi:10.1016/j.clinthera.2013.09.013

Cited by 96 publications

(67 citation statements)

References 33 publications

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“…Only CCO treatment resulted in a statistically significant decrease from baseline in the mean future science group www.futuremedicine.com wound area at the end of treatment (-44.9%; p = 0.0164) and at the end of follow-up (-53.8%; p = 0.012) [40]. Corresponding changes for the SMG group were +0.8 and +8.1%.…”

Section: Discussion Of Clinical Effectivenessmentioning

confidence: 91%

“…Cost-effectiveness of CCO in DFU Two cost analyses of CCO debridement in patients with DFU also yielded estimates favoring CCO over alternative debridement methods [40,53]. In an analysis of results from a randomized, open-label trial of 55 patients with DFU using a three-state Markov model, Motley et al calculated that the number of epithelialized weeks was 25% greater in patients treated with the CCO plus serial sharp debridement (35 weeks) versus other debridement methods (28 weeks) [39,53].…”

Section: Discussion Of Economic Analysesmentioning

confidence: 99%

“…Tallis et al [40] conducted an economic analysis alongside a multicenter, open-label, 12-week RCT of 48 patients with DFU treated with either CCO or SMG after baseline surgical debridement (with further surgical debridement as deemed necessary in either group). Resource use estimates included frequency of selective sharp debridement procedures between groups (mean of 1 and 7 for CCO and SMG groups during the trial, respectively) and physician office visits (6 and 12 during the trial, for CCO and SMG groups, respectively) associated with the evaluation and management of patients with DFU and CCO use.…”

Section: Discussion Of Economic Analysesmentioning

confidence: 99%

See 2 more Smart Citations

Comparative cost and clinical effectiveness of clostridial collagenase ointment for chronic dermal ulcers

Waycaster¹,

Carter

Gilligan

et al. 2018

J. Comp. Eff. Res.

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Chronic dermal ulcers affect approximately 2.4-4.5 million people in the USA and are associated with loss of function, decreased quality of life and significant economic burden. Debridement is a critical component of wound care involving removal of nonviable tissue from chronic wounds to stimulate the granulation and epithelialization process. Clostridial collagenase ointment has been used as a method of wound debridement for more than 50 years and is currently the only enzymatic debriding ointment with US FDA approval. This review discusses the results of recent real-world studies that build upon the evidence demonstrating the clinical effectiveness, cost-effectiveness and safety of clostridial collagenase ointment across wound types and care settings.

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Section: Discussion Of Clinical Effectivenessmentioning

confidence: 91%

Section: Discussion Of Economic Analysesmentioning

confidence: 99%

Section: Discussion Of Economic Analysesmentioning

confidence: 99%

See 1 more Smart Citation

Comparative cost and clinical effectiveness of clostridial collagenase ointment for chronic dermal ulcers

Waycaster¹,

Carter

Gilligan

et al. 2018

J. Comp. Eff. Res.

Self Cite

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“…Recently, Tallis et al (2013) showed that the collagenase ointment is tolerable and clinically effective in providing non-viable tissue removal and allow effective scar [16].…”

Section: Discussionmentioning

confidence: 99%

Healing incisional surgical wounds using Rose Hip oil in rats

Cavalcante¹,

Pessoa²,

Júnior³

et al. 2017

int arch med

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“…A capacidade de decompor o colágeno sem afetar as propriedades de outras proteínas, tornou a colagenase uma ferramenta aplicável nas ciências médicas para limpar feridas necrosadas, escaras, cicatrizes pós-operatórias, em queimaduras, no tratamento de psoríase e pediculoses, em casos de implantes e perdas ósseas, em casos de lesões de mamilos de mulheres em aleitamento, no tratamento de cicatrizes hipertróficas, no tratamento de fibroma uterino, de isquemias do coração, de glaucoma, no reparo de cartilagem, de queloides, no de hérnia de disco intervertebral, no da celulite, no debridamento de úlceras de pessoas diabéticas e na regeneração dos tecidos da pele (Takahashi et al, 1999, Özcan et al, 2002, Watanabe, 2004, Arakawa et al, 2012, Alipour et al, 2016, Tallis et al, 2013, Brunengraber et al, 2014, Chandika et al, 2015.…”

Section: Aplicações Na Indústria Biomédica E Terapêuticaunclassified

Colagenasas do pescado y sus aplicaciones industriales

Oliveira

Cunha

Assis

et al. 2017

Pubvet

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RESUMO.Colagenases são grupos de enzimas capazes de clivar a tripla-hélice do colágeno não tendo ação sobre outro tipo de proteína. São obtidas a partir de uma vasta gama de fontes, tais como tecido animal e vegetal. Uma fonte promissora na atualidade é a partir de resíduos negligenciados do processamento do pescado, tais como vísceras internas (intestino). Esta revisão objetivou realizar um levantamento quantitativo da produção cientifica relacionada à colagenase do pescado, bem como dissertar sobre as principais características bioquímicas e aplicações industriais dessa protease, com ênfase nas colagenases extraídas a partir de organismos aquáticos. Dessa forma, através de análise do Scopus, no período de 1963 a 2016, foram detectadas 274 citações ao termo "collagenase fish". A produção cientifica pertinente a colagenase do pescado está intrinsicamente relacionada a necessidade industrial de fontes alternativas dessas proteases colagenolíticas, devido sua extensa aplicação industrial, tais como nos segmentos alimentícios, biomédicos, terapêuticos e têxtil.Palavras chave: Biotecnologia, enzimas, pescado, protease, resíduos Fish collagenases and its industrial applicationsABSTRACT. Collagenases are a group of enzymes capable of cleaving the triple-helix collagen, having no action on another type of protein. They are obtained from a wide range of sources, such as animal and plant tissue. A promising source at present is from neglected fish processing residues, such as internal viscera (intestine). This review aimed to quantify the scientific production related to fish collagenase, as well as to discuss the main biochemical characteristics and industrial applications of this protease, with emphasis on collagenases extracted from aquatic organisms. Thus, through analysis of Scopus, from 1963 to 2016, 274 citations were detected to the term "collagenase fish". The scientific production relevant to fish collagenase is intrinsically related to the industrial need for alternative sources of these collagenolytic proteases, due to their extensive industrial application, such as in the food, biomedical, therapeutic and textile segments.

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Clinical and Economic Assessment of Diabetic Foot Ulcer Debridement with Collagenase: Results of a Randomized Controlled Study

Cited by 96 publications

References 33 publications

Comparative cost and clinical effectiveness of clostridial collagenase ointment for chronic dermal ulcers

Comparative cost and clinical effectiveness of clostridial collagenase ointment for chronic dermal ulcers

Healing incisional surgical wounds using Rose Hip oil in rats

Colagenasas do pescado y sus aplicaciones industriales

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