Clinical and economic burden of herpes zoster and postherpetic neuralgia in patients from the National Skin Centre, Singapore

Chen, Qiping; Hsu, Tun-Ying; Chan, Roy; Kawai, Kosuke; Acosta, Camilo J.; Walia, Anuj; Pan, Jiun Yit

doi:10.1016/j.dsi.2015.04.002

Cited by 7 publications

(14 citation statements)

References 25 publications

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“…HZ: herpes zoster; HZO: herpes zoster ophthalmicus; PHN: postherpetic neuralgia. Articles included: dermatological/soft tissue infection, 26 , 49 , 69 disseminated HZ, 51 , 54 , 68 , 70 , 71 ear-related/Ramsay-hunt syndrome, 54 , 68 , 71 encephalitis, 51 , 54 , 68 lower respiratory tract infection, 49 meningitis, 51 , 68 , 72 , 73 meningitis encephalitis, 71 neurological, 26 , 51 , 68–70 , 72 ocular/ophthalmic, 26 , 49 , 51 , 54 , 55 , 68–72 , 74–76 PHN, 26 , 27 , 35 , 46 , 47 , 52–54 , 59 , 68–71 , 75 , 77–89 vision loss, 90 , 91 and other. 26 , 51 , 54 , 70 , 72 , 92 .…”

Section: Resultsmentioning

confidence: 99%

“…Total all-cause direct medical cost per HZ case varied by geographical regions, at approximately USD 833–870 in Australia, 51 USD 188 in China, 53 USD 382–484 in Japan, 69 , 70 USD 265 in Korea, 101 and USD 371 in Singapore 75 (all costs converted to 2022-adjusted USD to facilitate comparison; Table 3 ). The direct medical cost per hospitalized HZ case was around USD 5,735 in Hong Kong 71 and USD 3,080 in Taiwan.…”

Section: Resultsmentioning

confidence: 99%

“… 47 Costs were also higher for HZ patients with PHN or other HZ-related complications than those without complications ( Table 3 ). 53 , 69 , 70 , 75 …”

Section: Resultsmentioning

confidence: 99%

“… 99 In Singapore, indirect cost due to absenteeism at work was the highest in the labor-productive age group of 50–59 years. 75 In Japan, indirect cost due to absenteeism in patients and caregivers increased with age owing to higher productivity loss among caregivers of older patients, and represented 19% of total HZ-related costs from the societal perspective. 69 …”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

A systematic literature review of the epidemiology and burden of herpes zoster in selected locales in Asia Pacific

Chen,

Abrahamson,

et al. 2024

Human Vaccines & Immunotherapeutics

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Herpes zoster (HZ) is a painful rash which typically affects older adults. This is of concern in Asia-Pacific given its aging population. As HZ epidemiology and burden are evolving, this systematic literature review aimed to update the current understanding of HZ burden and associated costs for selected Asia-Pacific locales. MEDLINE and Embase were searched for English articles of HZ studies conducted in Australia, China, Hong Kong, Japan, Korea, New Zealand, Singapore, and Taiwan. Eligible outcomes included HZ incidence and prevalence, occurrence of HZ-related complications, healthcare resource utilization, costs, and HZ-associated quality of life outcomes. This paper focused on HZ data in the general adult population ( N = 90 articles). Substantial HZ-related disease and economic burden were observed in these locales, consistent with global trends. These findings reinforce the increasing burden of HZ and need for preventive strategies, which may include raising awareness and encouraging timely vaccination.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“… 47 Costs were also higher for HZ patients with PHN or other HZ-related complications than those without complications ( Table 3 ). 53 , 69 , 70 , 75 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

A systematic literature review of the epidemiology and burden of herpes zoster in selected locales in Asia Pacific

Chen,

Abrahamson,

et al. 2024

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

show abstract

“…In Singapore, the cost of treating one patient with PHN is approximately SGD 414.69 [90]. The disease burden of PHN in China remains low.…”

Section: Individual and Social Effectsmentioning

confidence: 99%

An analysis and visualization of postherpetic neuralgia research between 1985 and 2022 using scientometrics

Cao

Zhang

et al. 2023

Preprint

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Background This study aimed to highlight the status of research on PHN between 1985 and 2022 through a bibliometric analysis and a historical review. Methods The Web of Science database was searched, and 3,386 relevant articles were included in the study. Bibliometric analysis was used to review the field distribution, regional distribution, and research topic evolution. Results Trends identified in the literature indicate that research on PHN is increasing globally. The United States is the leading country, and the University of California system is the leading institution in terms of publications. Glaxosmithkline had the highest number of citation bursts, indicating its important role in PHN research and drug development. PHN is primarily associated with older age and immunosuppression. Treatment mainly involves pharmacological, nonpharmacological, and interventional treatments, although data supporting the use of physical interventions are lacking. The main psychophysiological effects experienced by patients with PHN are anxiety, insomnia, and depression. Additionally, PHN results in a significant economic burden. Two vaccines have been approved for herpes zoster. Finally, animal models of PHN are inadequate. Conclusions The findings of this study provide valuable information for future research on PHN, e.g., research is needed on the mechanism of PHN, the development of suitable animal models, and the long-term effects of interventional treatment.

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Systematic Literature Review of Herpes Zoster Disease Burden in Southeast Asia

San Martin,

Aunhachoke,

Batac

et al. 2023

Infect Dis Ther

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Clinical and economic burden of herpes zoster and postherpetic neuralgia in patients from the National Skin Centre, Singapore

Cited by 7 publications

References 25 publications

A systematic literature review of the epidemiology and burden of herpes zoster in selected locales in Asia Pacific

A systematic literature review of the epidemiology and burden of herpes zoster in selected locales in Asia Pacific

An analysis and visualization of postherpetic neuralgia research between 1985 and 2022 using scientometrics

Systematic Literature Review of Herpes Zoster Disease Burden in Southeast Asia

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