Clinical and electrophysiological examination of pinch strength in patients with amyotrophic lateral sclerosis

Lee, John D.; Heshmat, Saman; Heggie, Susan; Thorpe, Kathryn A; McCombe, Pamela A.; Henderson, Robert D.

doi:10.1002/mus.27111

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Therefore, muscle strength is a critical outcome measure used in clinical trials to diagnose and assess ALS progression. [59][60][61] In rodent models, assessing grip strength provides a straightforward means of determining changes in muscle strength as ALS progresses. This assessment is often called the paw grip endurance (PaGE) test.…”

Section: Grip Strength Assessment Of Hindlimbsmentioning

confidence: 99%

Behavioral Paradigms in Rodent Models of Amyotrophic Lateral Sclerosis

Yao

2024

MRAJ

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Amyotrophic lateral sclerosis (ALS) remains an untreatable neurodegenerative disease without a cure or effective treatment, mainly due to elusive underlying mechanisms. ALS is primarily characterized by motor neuron dysfunction in the brain and spinal cord. However, it also exhibits non-motor symptoms such as executive, behavioral, and language dysfunction, making it challenging to establish informative disease models for relevant preclinic and clinical research. The discovery of ALS- causing genes, such as C9orf72 and SOD1, has paved the way for developing various animal models. Among these models, rodents have emerged as particularly valuable, demonstrating unique ALS-related behavioral defects in multiple behavioral tests. These models enable further understanding of disease mechanisms and provide sensitive and precise functional assessments of ALS-related defects for drug development. This report endeavors to present a chronological overview of various behavioral assessments, encompassing motion ability tests, cognitive evaluations, sensory analyses, and other paradigms described in rodent models of ALS. Our goal is to summarize and compare the behavioral alterations observed in diverse rodent models of ALS with distinct gene mutations, thus providing comprehensive references and guidance for advancing pathogenic and therapeutic research in ALS.

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Section: Grip Strength Assessment Of Hindlimbsmentioning

confidence: 99%

Behavioral Paradigms in Rodent Models of Amyotrophic Lateral Sclerosis

Yao

2024

MRAJ

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“…Split hand, characterized by preferential weakness and wasting of the abductor pollicis brevis (APB) and first dorsal interosseous (FDI) muscles with relative sparing of the abductor digiti minimi muscle (ADM), has showed good sensitivity and specificity in the differential diagnosis of ALS (Figure 1). 3 Besides, split plus sign, 4 split pinch grip strength, 5 and split elbow 6 have been observed by both clinical assessment of muscle strength and electrophysiological studies in ALS patients. Through comparing pairs of muscle groups in a large ALS cohort, Ludolph et al found that the muscles known to receive the more pronounced corticomotoneuronal (CM) connections was significantly weaker.…”

Section: Introductionmentioning

confidence: 97%

Split Phenomenon of Fasciculation between Antagonistic Muscles in Amyotrophic Lateral Sclerosis: An Ultrasound Study

et al. 2023

Can. J. Neurol. Sci.

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Objective: Paresis of muscle groups in patients with amyotrophic lateral sclerosis (ALS) tends to present split phenomena. We explored the split phenomenon of fasciculation in multiple antagonistic muscle groups in ALS patients. Methods: One hundred and forty ALS patients and 66 non-ALS patients were included from a single ALS center. Muscle ultrasonography (MUS) was performed to detect fasciculation in elbow flexor-extensor, wrist flexor-extensor, knee flexor-extensor, and ankle flexor-extensor. Split phenomena of fasciculation between different antagonistic muscle groups were summarized, and the possible influence factors were analyzed through stratified analysis. Results: The frequency of split phenomenon of fasciculation intensity was significantly higher than those of muscle strength (26.1% vs. 7.1% for elbow flexor-extensor, 38.3% vs. 5.7% for wrist flexor-extensor, 37.9% vs. 3.0% for knee extensor-flexor, and 33.6% vs. 14.4% for ankle flexor-extensor) (P < 0.01). For muscles with 0–1 level of muscle strength (the Medical Research Council, MRC, score), significance difference in mean fasciculation intensity was observed only in ankle flexor-extensor. For muscles with 2–5 level of muscle strength, significant dissociation of fasciculation grade was common, especially among patients with slow rapid progression rate and both upper and lower motor neuron (UMN and LMN) involvement. As for non-ALS patients, no significant difference was observed in fasciculation intensity between antagonistic muscles. Conclusion: Split phenomenon of fasciculation between antagonistic muscles was common and relatively specific in ALS patients. Muscle strength, progression rate, and UMN involvement were influence factors of the split phenomenon of fasciculation intensity.

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The strength of associations between ultrasound measures of upper limb muscle morphology and isometric muscle strength: An exploratory study

Whang,

Debenham,

Ogalo

et al. 2024

Muscle and Nerve

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Introduction/AimsAssessing upper limb muscle strength is important for understanding health outcomes, such as daily function and mortality. Ultrasound (US) is increasingly used to evaluate muscle health, but the relationship between its measures of morphology and isometric strength has not been thoroughly explored in upper limb muscles. The aim of this study was to evaluate the associations between US morphological measures and isometric strength in functionally relevant upper limb muscles in healthy adults.MethodsTwenty‐four healthy volunteers (30.0 ± 10.8 years) underwent B‐mode, axial US scans of the first dorsal interosseus (FDI), flexor pollicis longus (FPL), biceps brachii (BB), brachialis (BR), and triceps brachii lateral head (TB). Participants performed corresponding maximal voluntary contractions (MVC), including first digit distal phalanx flexion, second digit abduction, and elbow flexion and extension. US images were segmented to obtain maximal muscle thickness (MT) and cross‐sectional area (CSA).ResultsStrong positive correlations were found between muscle strength and BB MT (r = .83; p < .001), BR CSA (r = .84; p < .001), and TB MT (r = .70; p < .001). Moderate positive correlations were found for strength and FDI CSA (r = .67; p < .001), FDI MT (r = .47; p < .05), FPL CSA (r = .54; p < .01), and FPL MT (r = .42; p < .05). No significant correlation was found between strength and BR MT (r = .16; p > .05).DiscussionOur data showed moderate‐to‐strong associations between US muscle morphology and strength, suggesting that US is likely a good biomarker for strength. However, its use is not “one size fits all.” Future investigations should continue to assess this relationship in different muscles and expand the generalizability to clinical populations.

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Clinical and electrophysiological examination of pinch strength in patients with amyotrophic lateral sclerosis

Abstract: Florbetapir and 18F-FDG PET/CT in systemic immunoglobulin light chain amyloidosis involving the peripheral nerves. Clin Nucl Med. 2016; 41(2):e115-e117.

Cited by 4 publications

References 18 publications

Behavioral Paradigms in Rodent Models of Amyotrophic Lateral Sclerosis

Behavioral Paradigms in Rodent Models of Amyotrophic Lateral Sclerosis

Split Phenomenon of Fasciculation between Antagonistic Muscles in Amyotrophic Lateral Sclerosis: An Ultrasound Study

The strength of associations between ultrasound measures of upper limb muscle morphology and isometric muscle strength: An exploratory study

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