Clinical and Epidemiological Characteristics of Pandemic Influenzae A/(H1N1) in Hospitalized Pediatric Patients at a University Hospital, Istanbul

Hançerli, Selda; Somer, Ayper; Salman, Nuran; Elshana, Hussam; Demirkol, Demet; Kanturvardar, Melis; Cıblak, Meral A.; Badur, Selim; Devecioğlu, Ömer

doi:10.5152/ced.2010.15

Cited by 4 publications

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“…The mean duration of fever was 4.8 days in these patients, which was similar to that of our patients (4.63 days). Fever (100%) and other symptoms and signs, reported by Hançerli et al [35] among hospitalized children in Istanbul included cough (82%), dyspnea (32%), vomiting (27%), myalgia (19%), headache (18%), rhinorhea (15%), diarrhea (13%), and sore throat (8%).…”

Section: Discussionmentioning

confidence: 86%

Virological and clinical characterizations of respiratory infections in hospitalized children

et al. 2013

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BackgroundThe purpose of this study was to determine the incidence and seasonal distribution of viral etiological agents and to compare their clinical manifestations and disease severity, including single and co infections.MethodsMultiplex reverse-transcription PCR was performed for the detection of viruses in nasopharyngeal aspirat. Disease severity was grouped using a categorization index as very mild/mild, and moderate/severe. Clinical and laboratory characteristics of hospitalized children with viral respiratory tract infection were analyzed.ResultsViral pathogens were detected in 103/155 (66.5%) of patients. In order of frequency, identified pathogens were respiratory syncytial virus (32.0%), adenovirus (26.2%), parainfluenza viruses type 1–4 (19.4%), rhinovirus (18.4%), influenza A and B (12.6%), human metapneumovirus (12.6%), coronavirus (2.9%), and bocavirus (0.9%). Coinfections were present in 21 samples. Most of the children had very mild (38.8%) and mild disease (37.9%). Severity of illness was not worse with coinfections. The most common discharge diagnoses were "URTI" with or without LRTI/asthma (n=58). Most viruses exhibited strong seasonal patterns. Leukocytosis (22.2%) and neutrophilia (36.6%) were most commonly detected in patients with adenovirus and rhinovirus (p<0.05). Monocytosis was the most remarkable finding in the patients (n=48, 53.3%), especially in patients with adenovirus (p<0.05).ConclusionsRSV and RhV were associated with higher severity of illness in hospitalized children. RSV found to account for half of LRTI hospitalizations. In AdV and FluA and B infections, fever lasted longer than in other viruses. Coinfections were detected in 21 of the patients. The presence of coinfections was not associated with increased disease severity.

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Section: Discussionmentioning

confidence: 86%

Virological and clinical characterizations of respiratory infections in hospitalized children

et al. 2013

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“…Severe neutropenia in influenza outbreaks also plays an important role in the development of secondary bacterial infections. 10,11 In this patients, respiratory tract infections played an important role in the etiology. Since the patients had non-specific symptoms and the clinic had a mild course, no examinations were performed to determine the causative agent.…”

Section: Discussionmentioning

confidence: 89%

Investigation of the incidence of vitamin B12 deficiency in leukopenia and neutropenia secondary to infection

Sarbay¹

2019

Int J Contemp Pediatr

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Background: Infections and nutritional deficiencies are the most common causes of the leucopenia and neutropenia. In this study, we aimed to find the incidence of vitamin B12 deficiency in patients with leukopenia and neutropenia secondary to infection.Methods: Between September 2018 and December 2018, patients who were referred to Diyarbakır Children Hospital's Pediatric Hematology and Oncology Clinic for leukopenia and/ or neutropenia were thought to develop secondary to infection retrospectively evaluated.Results: Of the 60 patients that evaluated, 23(38.3%) were female and 37(61.7%) were male. The mean age±SD was 4.75±4.5 years. Severe neutropenia was detected in 5(8.3%), moderate neutropenia in 31(51.7%) and mild neutropenia in 17(28.3%) patients. Neutrophil counts were within normal limits in 7(11.7%) patients. When vitamin B12 levels were examined, 17(28.3%) patients had B12 deficiency.Conclusions: Investigation and treatment of vitamin B12 deficiency in patients with leukopenia and neutropenia may shorten the duration of cytopenia and prevent the development of secondary complications.

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“…Bu nedenle birçok çalışmada CR'nin bakteriyel enfeksiyon tanısında kullanılabilecek güvenilir bir akut faz reaktanı olduğu bildirilmiştir (5,9,12,19,21). Ancak CRP değerlerinin yanık, travma ve otoinflamatuar hastalıklar gibi durumlarda, hatta birçok viral enfeksiyonda da yükselebildiği bildirilmiştir (4,6,7,24). Son dönem çalışmalarda bakteriyel enfeksiyonlarda CRP'nin prokalsitonine göre daha geç artış gösterdiği, duyarlılık ve özgüllüğünün daha düşük olduğu bildirilmektedir (5,10,11,15,23,26,27).…”

Section: Discussionunclassified

C-Reakti̇f Protei̇n Bakteri̇yel Enfeksi̇yon Tanisinda Güveni̇li̇r Bi̇r Beli̇rteç Mi̇di̇r?

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et al. 2017

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi

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Bu çalışmada, hastanede yatan süt çocuğu hastalarında, kesinleşmiş tanılar ile Creaktif protein (CRP) düzeylerinin karşılaştırılması ve CRP'nin bakteriyel enfeksiyon tanısında güvenilir bir belirteç olup olmadığının incelenmesi amaçlandı. Materyal ve metot: Yaşları bir-24 ay arası değişen 192 hastanın dosyaları geriye dönük olarak incelendi. Olguların yaş, cinsiyet ve tanı gibi demografik verileri ile lökosit, lenfosit, nötrofil, trombosit sayıları, hemoglobin, CRP düzeyleri ve eğer alınmışsa akciğer grafisi raporları, tam idrar tahlili, idrar kültürü, gayta mikroskopisi, gayta kültrü, kan kültürü, beyin omurilik sıvısı (BOS) mikroskopisi ve BOS kültürü sonuçları kaydedildi. Bulgular: Olguların 83'ü (% 43,2) kız ve 109'u (% 56,8) erkek idi. Olguların 78'i (% 40,6) bakteriyel enfeksiyon tanısı alırken, 114'ü (% 59,4) viral enfeksiyon tanısı aldı. Bakteriyel enfeksiyon grubunda ortalama CRP düzeyleri 1,94±3,28 mg/dl iken viral enfeksiyon grubunda 1,13±1,51 mg/dl idi (p = 0,001). İki grup arasında istatistiksel olarak anlamlı fark saptandı. ROC analizinde CRP'nin bakteriyel enfeksiyon saptamadaki duyarlılığı % 60,26, özgüllüğü % 45,61 (AUC [%95 Cl] 0,534 ve p = 0,429), pozitif öngörücü değeri % 43,09 ve negatif öngörücü değeri % 62,67 olarak hesaplandı. Sonuç: CRP değerlerinin bakteriyel enfeksiyonlarda viral enfeksiyonlara göre anlamlı düzeyde arttığı ancak bakteriyel enfeksiyonu viral enfeksiyondan ayırt etmedeki duyarlılık ve özgüllüğünün zayıf olduğu gözlendi.

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Clinical and Epidemiological Characteristics of Pandemic Influenzae A/(H1N1) in Hospitalized Pediatric Patients at a University Hospital, Istanbul

Cited by 4 publications

References 0 publications

Virological and clinical characterizations of respiratory infections in hospitalized children

Virological and clinical characterizations of respiratory infections in hospitalized children

Investigation of the incidence of vitamin B12 deficiency in leukopenia and neutropenia secondary to infection

C-Reakti̇f Protei̇n Bakteri̇yel Enfeksi̇yon Tanisinda Güveni̇li̇r Bi̇r Beli̇rteç Mi̇di̇r?

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