Clinical and epidemiological characterization of patients with psoriasis and the prescription of biological therapy in Venezuela: a cross-sectional study

Abstract

Introduction Psoriasis is a chronic disease that affects the skin. One hundred twenty-five million people around the world suffer from this condition. In specific groups of patients, the joints may also be involved. To control and follow-up patients with psoriasis, psoriasis area severity and dermatological quality of life measurements were established. Both parameters are necessary for the initiation of biological therapy, as specified in the psoriasis management guide (2015) of the national committee of rheumatological, immunological, and bone metabolism diseases of the Venezuelan Institute of Social Security. Objective To characterize the clinical and epidemiological variables and the prescription of biological therapy in patients with psoriasis who access the high-cost dispensing program of the Venezuelan Institute Social Security (IVSS) pharmacy. Methods This is a descriptive, cross-sectional study. Results A total of 374 patient records were assessed. The male gender was more frequent, with 56.1% (p <0.001), mostly from Caracas city. In comparing age groups with sex, a difference among these was observed (p <0.05). 57.5% previously used methotrexate, 6.68% biological, 3.2% topical steroids, and 31% did not report which type of previous therapy they had received. Amongst the clinical presentations, 70% corresponded to plaque psoriasis. 79% of the patients presented moderate activity according to the Psoriasis Area and Severity Index (PASI): Eleven percent were assessed with the Dermatology Life Quality Index (DLQI); 39% of them reported an extremely important effect. The anergic range of the Mantoux test represented 70.9% of the cases, and 0.3% took the booster evaluation. Chest X-ray was reported normal in 95% of the cases. The most demanded biological medicine was etanercept, in 52% of the cases. Conclusions Male gender and its association with psoriasis was an important finding. The need to improve the administrative components in completing the medication request formats and strengthen clinical measurements and good medical practice was also found.

Unmet needs in the management of psoriasis in Latin America: a systematic review

“…Studies from Venezuela 18 and Argentina 19 have reported similar rates of LTBI among Pso patients (10.4% and 16%, respectively). In Colombia, 20 the prevalence was significantly higher at 99%.…”

“… Was appropriate statistical analysis used? Descriptive cross-sectional studies Rada JR, et al 18 Figueroa P, et al 19 Úsuga F, et al 14 Lopes N, et al 6 Lopes LC, et al 17 Silveira MSN, et al 33 Gonçalves LMT, et al 21 Lopes N, et al 16 Was the sample frame appropriate to address the target population? Were study participants sampled in an appropriate way?…”

“…Rada et al investigated the prevalence of Latent Tuberculosis (LTBI) among 374 Venezuelan Pso patients 17 who were candidates for IMB treatment. 18 They found that 70.9% had a non-reactive Purified Protein Derivative (PPD) test, and 10.4% had a reaction of ≥10 mm. Figueroa et al reported a prevalence of LTBI of 16% and a 5% per year incidence rate among 93 Argentinian patients receiving systemic treatment.…”