Clinical and epidemiological comparison of patients affected by palmoplantar plaque psoriasis and palmoplantar pustulosis: a case series study

Brunasso, Alexandra Maria Giovanna; Puntoni, Matteo; Aberer, W.; Delfino, Chiara; Fancelli, Laura; Massone, Cesare

doi:10.1111/bjd.12223

Cited by 120 publications

(168 citation statements)

References 37 publications

Supporting

Mentioning

140

Contrasting

Unclassified

Order By: Relevance

“…While these two types overlap clinically, some evidence suggests that palmoplantar pustulosis may be a genetically distinct form of psoriasis. 51, 56, 57 In this study we focused on investigating the effects that anatomical involvement of the palms and soles can have on QoL, but future endeavors to compare patient-reported outcomes between the two subtypes of palmoplantar psoriasis may provide further insight.…”

Section: Discussionmentioning

confidence: 99%

Palmoplantar psoriasis is associated with greater impairment of health-related quality of life compared with moderate to severe plaque psoriasis

Chung

Duffin

Takeshita

et al. 2014

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Background The impact of palmoplantar psoriasis on health-related quality of life (QoL) is largely unknown. Objective To compare clinical characteristics and patient-reported outcomes between patients with palmoplantar psoriasis and moderate-to-severe plaque psoriasis. Methods We conducted a cross-sectional study of patients with plaque psoriasis (N=1,153) and palmoplantar psoriasis (N=66) currently receiving systemic or light treatment for psoriasis. Results Patients with palmoplantar psoriasis were more likely to report Dermatology Life Quality Index scores that correspond to at least a moderate impact on QoL (odds ratio [OR] 2.08; 95% confidence interval [CI], 1.20-3.61); problems with mobility (OR 1.98; 95% CI, 1.10-3.58), self-care (OR 3.12; 95% CI, 1.24-7.86), and usual activities (OR 2.47; 95% CI, 1.44-4.22) on the European Quality of Life-5 Dimensions questionnaire; and heavy topical prescription use of at least twice daily in the preceding week (OR 2.81; 95% CI, 1.63-4.85) than those with plaque psoriasis. Limitations Our assessment tools may not account for all dimensions of health-related QoL affected by palmoplantar disease, and these results may not be generalizable to patients with milder forms of psoriasis. Conclusion Patients with palmoplantar psoriasis suffer from greater health-related QoL impairment and are more likely to report heavy use of topical prescriptions than those with moderate-to-severe plaque psoriasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Palmoplantar psoriasis is associated with greater impairment of health-related quality of life compared with moderate to severe plaque psoriasis

Chung

Duffin

Takeshita

et al. 2014

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

show abstract

“…Another controversy is related to the classification of generalized PP alone or accompanied by PV as distinct subtypes with different etiologies [17]. Likewise, localized PP, which is often limited to palms and soles (i.e., palmoplantar pustulosis), has been regarded by several authors as a separate entity rather than a clinical variant of psoriasis [17, 18]. However, a close relationship between localized PP and PV is likely suggested by lack of significant epidemiologic differences, frequent coexistence in the same patients, and largely shared genetic background [18].…”

Section: Introductionmentioning

confidence: 99%

IL-6 as a Druggable Target in Psoriasis: Focus on Pustular Variants

Saggini

Chimenti

Chiricozzi

2014

Journal of Immunology Research

View full text Add to dashboard Cite

Psoriasis vulgaris (PV) is a cutaneous inflammatory disorder stemming from abnormal, persistent activation of the interleukin- (IL-)23/Th17 axis. Pustular psoriasis (PP) is a clinicopathological variant of psoriasis, histopathologically defined by the predominance of intraepidermal collections of neutrophils. Although PP pathogenesis is thought to largely follow that of (PV), recent evidences point to a more central role for IL-1, IL-36, and IL-6 in the development of PP. We review the role of IL-6 in the pathogenesis of PV and PP, focusing on its cross-talk with cytokines of the IL-23/Th17 axis. Clinical inhibitors of IL-6 signaling, including tocilizumab, have shown significant effectiveness in the treatment of several inflammatory rheumatic diseases, including rheumatoid arthritis and juvenile idiopathic arthritis; accordingly, anti-IL-6 agents may potentially represent future promising therapies for the treatment of PP.

show abstract

“…Иногда заболевание впервые возникало после длительного лечения пре-паратами лития. Курение и неблагоприятные фак-торы окружающей среды (высокая влажность и тем-пература) усугубляют его течение, также была выяв-лена более выраженная ассоциация между ладонно-подошвенным пустулезным псориазом и курением, особенно у женщин [1,8]. Отказ от курения был важным лечебным мероприятием, учитывая выяв-ленную аномальную реакцию на никотин [5].…”

Section: клиническая дерматология и венерология 6 2014unclassified

Pustular palmoplantar conditions

Bakhlykova¹,

Филимонкова²,

Kurlovich³

et al. 2014

Klin. dermatol. venerol.

View full text Add to dashboard Cite

Представлены анализ данных литературы, результаты собственных наблюдений наиболее часто встречающихся хронических заболеваний ладоней и подошв, протекающих с пустулизацией. К ним относят ладонно-подошвенный псориаз, ладонно-подошвенный пустулез, бактерид пустулезный Эндрюса, акродерматит стойкий пустулезный Аллопо. Рассмотрены особенности клинической картины, провоцирующие факторы, характер течения, вопросы дифференциаль-ной диагностики. Высказано отношение авторов к вопросам нозологической идентификации данной патологии. Ключевые слова: ладонно-подошвенный псориаз, ладонно-подошвенный пустулез, бактерид пустулезный Эндрюса, акродерматит стойкий пустулезный Аллопо.The literature data and authors' own observations of the most common chromic pustular palmoplantar diseases (palmoplantar psoriasis, palmoplantar pustulosis, pustular Andrew's bacterid, acrodermatitis continua of Hallopeau) are analyzed. The features of clinical presentation, provoking factors, the disease course, and problems of differential diagnosis are discussed. The authors share their opinion about nosological identification of this pathology.

show abstract

Clinical and epidemiological comparison of patients affected by palmoplantar plaque psoriasis and palmoplantar pustulosis: a case series study

Cited by 120 publications

References 37 publications

Palmoplantar psoriasis is associated with greater impairment of health-related quality of life compared with moderate to severe plaque psoriasis

Palmoplantar psoriasis is associated with greater impairment of health-related quality of life compared with moderate to severe plaque psoriasis

IL-6 as a Druggable Target in Psoriasis: Focus on Pustular Variants

Pustular palmoplantar conditions

Contact Info

Product

Resources

About