Clinical and Epidemiological Features of Acute Corrosive Poisonings

Chibishev, Andon; Pareska, Zenina; Chibisheva, Vesna; Simonovska, Natasa

doi:10.5455/medarh.2012.66.s11-s15

Cited by 14 publications

(22 citation statements)

References 19 publications

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“…This study found that most of cases ingested alkaline caustic agents (48.9%). Many studies reported that alkaline agents are the most common and widely spread caustic agents used as household and industrial cleaners and are easily available at home (Lakshmi et al,2013).While, Chibishev et al (2012) found that, toxicity was commonly due to acidic agents compared with alkaline agents.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors Predicting Stricture Formation and Death in Patients with Caustic Ingestion

Mahmoud

Mohammed

Husseini

et al. 2019

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Background: Caustic ingestion is still a difficult medical problem, and the outcome is often unexpected. Objectives: This study assessed the usefulness of intoxication data, clinical data and some laboratory parameters in predicting the outcome following caustic ingestion, and test the applicability of DROOL Score (DS) as a prognostic indicator of oesophageal stricture. Methods: Ninety-two patients with caustic ingestion admitted to Poison Control Centre Ain Shams University (PCCASU), during the period from 1st June to November 30, 2015 were prospectively studied. Diagnoses of stricture made via barium study. Results: Sixty-six percentage of cases were children under 5 years. In 48.9% of cases, the caustic agent was alkaline. Symptoms and signs can adequately predict the outcome of corrosive patients. DROOL Score and Total Leucocytic Count (TLC) ≥ 20,000 are useful tools for predicting both stricture formation and mortality, in addition blood pH ˂ 7.2 can also predict mortality. A new value of DS ≤ 5.5 to predict stricture formation and mortality of corrosive patients was proposed. Conclusion: Clinical manifestations can adequately predict the outcome also; DS and TLC ≥ 20,000 have predictive value for outcome prediction of corrosive patients. Moreover, blood pH ˂ 7.2 can predict mortality. A new value of DS ≤ 5.5 was identified as a prognostic indicator of outcome in caustic patients.

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Section: Discussionmentioning

confidence: 99%

Risk Factors Predicting Stricture Formation and Death in Patients with Caustic Ingestion

Mahmoud

Mohammed

Husseini

et al. 2019

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…The present study showed that alveolar opacities were seen in chest X-ray in 75% of corrosive poisoning cases due to aspiration pneumonitis. Chibishev et al, (2012) reported that patients poisoned by any corrosive substance can develop respiratory complications which depend on the type and the concentration of the corrosive substance.…”

Section: Discussionmentioning

confidence: 99%

Prospective Study on Acute Poisoning Related Deaths in Menoufia Poisoning and Addiction Control Center (MPCC), Menoufia University Hospitals

Zanaty

2017

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Introduction: Acute poisoning is a common medical emergency that causes morbidity and mortality. Acute poisoning fatality is of medical, legal and social significance. Aim of the work: The present work aimed at describing the demographic, characters of deaths due to acute poisoning (type and manner of poisoning), management and mechanism of death. Subjects and Methods: Prospective study on deaths due to acute poisoning which admitted to MPCC through a period from 1-1-2015 to 31-12-2016. Cases were evaluated. The results were further studied by statistical tests. Results: During the study period, 4,834 acute poisoned cases were admitted in MPCC. Among which 78 cases (1.6) % were died. The most common age of deaths was 7-18 years 41% followed, by age >18-30 years 33.3%. Females surpassed males (59%), students accounted 41% followed by farmers 23%. The majority of deaths were single and from rural areas. More than fifty percent of poisoned cases were due to Aluminum phosphide followed by insecticides 25%. Oral ingestion was the prominent method of intake 94.4%. Suicidal intention was more common than accidental cases (74.4 % versus 25.6%). Suicide was significantly common in females age groups (7-18) and (>18-30) years mainly in students and non-worker cases.. Metabolic acidosis was significantly correlated to Aluminum phosphide and insecticides, while hypoxia was significantly associated with Dormex and corrosive poisoning. ECG changes showed arrhythmia in Aluminum phosphide poisoning. Meanwhile bradycardia was associated to dormex and insecticides poisoning. Low blood cholinesterase level was significantly present in insecticides poisoned cases. There was significant relation to cardiac arrest as a cause of death to Aluminum phosphide cases. Conclusion and recommendation: Suicide was significantly common in females age groups (7-18) and (>18-30) years mainly in students and non-worker cases. The majority of cases were single and from rural areas. Most commonly used agents are aluminum phosphide and insecticides. Cardiac arrest was the main cause of death in aluminum phosphide poisoned cases. The mortality due to poisoning can be reduced by conducting educational programs in rural areas, restrict the availability of aluminum phosphide and insecticides, keep pesticides away from easy to use for suicide and providing needy people by poison information danger.

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“…The time elapsed from acid ingestion to hospitalisation varied between one and six hours [(3.45±1.36) h], that is, well within the optimal time frame for urgent EGD of less than 24 h after ingestion (9).…”

Section: Resultsmentioning

confidence: 99%

Severe Renal Function Impairment in Adult Patients Acutely Poisoned with Concentrated Acetic Acid

Chibishev¹,

Šikole

Pereska³

et al. 2013

Archives of Industrial Hygiene and Toxicology

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Acetic acid is a widely used organic acid with corrosive properties that depend on its concentration. If acetic acid is ingested in concentrations above 30 % it may severely damage the upper gastrointestinal tract and cause intravascular haemolysis, which can result in severe kidney and liver disorders and disseminated intravascular coagulation. In this retrospective study, we analysed acetic acid ingestion data collected at the University Clinic for Toxicology of Skopje, Macedonia from 1 January 2002 to 31 December 2011. The analysis included systemic complications, kidney damage, and the outcomes in particular. Over the ten years, 84 patients were reported at the Clinic to have ingested highly concentrated acetic acid. Twenty-eight developed kidney disorders, while the remaining 56 had no complications. Fatal outcome was reported for 11 patients, seven of whom had systemic complications and four severe gastrointestinal complications.

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Clinical and Epidemiological Features of Acute Corrosive Poisonings

Cited by 14 publications

References 19 publications

Risk Factors Predicting Stricture Formation and Death in Patients with Caustic Ingestion

Risk Factors Predicting Stricture Formation and Death in Patients with Caustic Ingestion

Prospective Study on Acute Poisoning Related Deaths in Menoufia Poisoning and Addiction Control Center (MPCC), Menoufia University Hospitals

Severe Renal Function Impairment in Adult Patients Acutely Poisoned with Concentrated Acetic Acid

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