Severe Renal Function Impairment in Adult Patients Acutely Poisoned with Concentrated Acetic Acid

Chibishev, Andon; Šikole, Aleksandar; Pereska, Zanina; Chibisheva, Vesna; Simonovska, Natasha; Orovchanec, Nikola

doi:10.2478/10004-1254-64-2012-2275

Cited by 10 publications

(12 citation statements)

References 14 publications

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“…1,19 In the Brusin review, nearly 60% of the 105 patients who developed pneumonia as a consequence of acid ingestion died, 7 whilst mortality approached 40% in those with systemic complications in patients studied by Chisishev. 2 Haemolysis and renal failure is reported in all cases of acute acetic acid poisoning. The exact mechanism remains unclear, though it is likely related to a combination of direct renal tubular damage by the acid itself and the effect of myoglobin deposition secondary to erythrocyte haemolysis.…”

Section: Discussionmentioning

confidence: 99%

“…Its most common form found for domestic use is that of dietary vinegar (2-6%) 1 ; however, highly concentrated solutions of up to 80% are frequently used in Eastern Europe and Russia in the production of homemade vegetable preservatives and cleaning solutions. 2 Consequently, its ease of access and high potency make it one of the most common forms of self-harm in Eastern Europe with mortality rates as high as 20%.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The exact mechanism remains unclear, though it is likely related to a combination of direct renal tubular damage by the acid itself and the effect of myoglobin deposition secondary to erythrocyte haemolysis. 2,20 Some authors have reported good outcomes following early plasmapheresis, thereby directly removing the caustic substance and preventing it from causing prolonged tubular damage. The benefits of one single session of plasmapheresis versus multiple courses have yet to be investigated.…”

Section: Discussionmentioning

confidence: 99%

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Successful management of 70% acetic acid ingestion on the intensive care unit: A case report

Ratcliffe

Baker

Smith

2017

Journal of the Intensive Care Society

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Acetic acid is an organic acid available in concentrations from 2 to 80%. Whilst lower concentrations of 2-6% are more commonly used as the table top condiment, vinegar, much stronger solutions are regularly used in Eastern Europe as food preservatives and cleaning solutions. Oral ingestion of greater than 12% has been reported to cause haemolysis, renal failure, shock and death. Most reported cases of deliberate or accidental poisoning are from Russia and Eastern Europe in the 1980s, with very little currently in western publications. We present the case of a female patient who attempted suicide by drinking 250 ml of 70% acetic acid. Her widespread gastrointestinal injuries were managed conservatively, and despite suffering extensive upper airway and renal complications, she was successfully decannulated and discharged home after a prolonged intensive care and hospital stay.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Successful management of 70% acetic acid ingestion on the intensive care unit: A case report

Ratcliffe

Baker

Smith

2017

Journal of the Intensive Care Society

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“…Most often these injuries can result in post corrosive complications such as stenosis and they can even end lethally due to perforation or tracheal necrosis (3,4). Acute poisonings with corrosive substances are almost regularly followed by complications such as acute renal failure, DIC, fistula, pneumonia, anemia; they usually prolong the hospital stay of patients and can be reason for fatal end in patients during the chronic phase (5). Unlike some systemic complications such as acute renal failure or DIC, which mainly result from acetic acid poisonings, respiratory complications can be found in patients poisoned by almost any corrosive substance, and the severity of the respiratory injuries depend on the type and the concentration of the chemical corrosive agent (6).…”

Section: Introductionmentioning

confidence: 99%

Respiratory Complications from Acute Corrosive Poisonings in Adults

Chibishev¹,

Simonovska²,

Boz̆inovska³

et al. 2014

Mater Sociomed

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Introduction: Acute corrosive poisonings are caused by ingestion of corrosive chemicals which are most commonly used as household agents. Intoxications with these kind of agents produce numerous and severe post-corrosive complications of the upper gastrointestinal tract. On the other hand, our experience showed that corrosive agents may also cause injuries of the respiratory system, which makes the treatment very hard and additionally complicates the severe clinical condition of the patient. Objective: The aim of the study is to show the incidence of respiratory complications in acute corrosive poisonings, the need of various clinical investigations and also the treatment and final outcome of these kind of poisoning. Methods: We retrospectively analyzed clinical records of 415 patients hospitalized and treated at the University clinic for toxicology and urgent internal medicine, in Skopje, Republic of Macedonia, in the period between 2007 and 2011. The protocol consisted of methods for analyzing the systemic complications, with an accent on the post-corrosive respiratory complications. Results: From the total number of patients even 98 (23.61%) exhibited systemic complications, from which 51 (52.04%) are respiratory complications. The majority of patients are female (n=40, 78.43%) and the most common complication is pneumonia (n=47). The youngest patient in this study was 14 and the oldest was 87 years old. Conclusion: Besides the gastrointestinal complications in the acute corrosive poisonings respiratory complications are also very often. They complicate the clinical state of patient and very often lead to fatal endings.

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Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid

Hou

Wang

et al. 2014

Br J Nutr

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Tributyrin (TBU) is a good dietary source of butyrate and has beneficial effects on the maintenance of normal intestinal morphology. The present study tested the hypothesis that dietary TBU supplementation could alleviate intestinal injury in the acetic acid (ACA)-induced porcine model of colitis. A total of eighteen piglets (25 d old) were randomly allocated to one of three treatment groups (control, ACA and TBU). The control and ACA groups were fed a basal diet and the TBU group was fed the basal diet supplemented with 0·1 % TBU. On day 15 of the trial, under anaesthesia, a soft catheter was inserted into the rectum of piglets (20 -25 cm from the anus), followed by administration of either saline (control group) or ACA (10 ml of 10 % ACA solution for ACA and TBU groups). On day 22 of the trial, after venous blood samples were collected, piglets were killed to obtain mid-ileum and mid-colon mucosae. Compared with the control group, the ACA group exhibited an increase (P,0·05) in lymphocyte counts, creatinine, PGE 2 , and malondialdehyde concentrations and diamine oxidase and inducible NO synthase activities in the plasma and lymphocyte density in the colon and a decrease in insulin concentrations and glutathione peroxidase activity, ileal villus height:crypt depth ratios and goblet cell numbers in the colon. These adverse effects of ACA were attenuated by TBU supplementation. Moreover, TBU prevented the ACA-induced increase in caspase-3 levels while enhancing claudin-1 protein and epidermal growth factor receptor (EGFR) mRNA expression in the colonic mucosa. Collectively, these results indicate that dietary supplementation with 0·1 % TBU alleviates ACA-induced intestinal injury possibly by inhibiting apoptosis, promoting tight-junction formation and activating EGFR signalling.

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Severe Renal Function Impairment in Adult Patients Acutely Poisoned with Concentrated Acetic Acid

Cited by 10 publications

References 14 publications

Successful management of 70% acetic acid ingestion on the intensive care unit: A case report

Successful management of 70% acetic acid ingestion on the intensive care unit: A case report

Respiratory Complications from Acute Corrosive Poisonings in Adults

Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid

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