Successful management of 70% acetic acid ingestion on the intensive care unit: A case report

Ratcliffe, Andrew; Baker, Andrew; Smith, Daniel A.

doi:10.1177/1751143717711062

Cited by 12 publications

(5 citation statements)

References 18 publications

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“…Toxins capable of causing periportal necrosis are more commonly encountered in human medicine, and include 2-chloropropane, albitocin, alloxan, allyl compounds, cocaine, manganese compounds, pemphigus vulgaris toxin, ferrous sulfate, lamotrigine, mesalamine, phosphorus, synthalin, and acetic acid. 15,19 Of the few compounds with known toxic mechanisms, the majority do not require bioactivation, and cause periportal injury via the direct cytopathic effect of the highest concentration of toxin carried by the portal blood. 7,18…”

Section: Discussionmentioning

confidence: 99%

Clinical and pathologic features of acute bovine liver disease in Australia

et al. 2021

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Acute bovine liver disease (ABLD) is a sporadic hepatic disease affecting cattle in southern Australia, characterized histologically by striking periportal hepatocellular necrosis. The cause of ABLD is unknown; however, the seasonality and acute presentation of outbreaks suggest mycotoxin involvement. We describe here the clinical and pathologic findings of ABLD in 45 naturally affected cattle from 13 outbreaks occurring from 2010 to 2019 in Victoria, Australia. Outbreaks occurred in herds located along the southern coastal plain of Victoria and were observed most frequently in lactating dairy cattle. Clinical signs commonly included a combination of mild photosensitization, progressive neurologic signs, and hypogalactia, which preceded death by ≤ 48 h. All affected animals had marked elevations in activities of glutamate dehydrogenase, aspartate aminotransferase, and gamma-glutamyl transferase. At autopsy, the most common lesions were serosal petechiae and/or gastrointestinal hemorrhage, and hepatomegaly with a pronounced hepatic reticular pattern. The principal histologic lesion was widespread—severe periportal hepatocellular coagulative necrosis and erythrocyte pooling—which often extended to massive necrosis. Lesions in other organs were uncommon. Our study of ABLD suggests involvement of a potent hepatotoxin that is either directly cytopathic or requires bioactivation by periportal-specific enzymes.

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Section: Discussionmentioning

confidence: 99%

Clinical and pathologic features of acute bovine liver disease in Australia

et al. 2021

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“…A link between acetic acid consumption and ketosis has been demonstrated in animal studies. [ 28 ] Reports of complications or fatalities related to vinegar or acetic acid ingestion are mostly secondary to consumption of concentrated forms of acetic acid [ 29 – 31 ]. We did find one fatality reported to homicidal massive ingestion of dietary vinegar in a pediatric patient [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Severe Metabolic Acidosis: A Case of Triple Hit with Ketogenic Diet, Vinegar, and Metformin in an Obese Patient

Rana

Mansoor

Assad

et al. 2020

Case Reports in Nephrology

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Obesity is an epidemic with high burden of disease. It is directly proportional to increased risk of morbidity and mortality. Ketogenic diet and herbal supplements have recently gained popularity amongst patients struggling with weight loss. There are limited data available for most of these supplements contrary to the claims laid by the mainstream media. Due to lack of awareness, this patient population is at high risk of adverse effects. We present a case of severe acidosis secondary to ketogenic diet and acetic acid (vinegar) ingestion. The use of dietary acetic acid is usually well tolerated; however, in this case, the large quantities and presence of acute renal injury may have worsened the acidosis. Severe ketosis in setting of ketogenic diets is a serious complication, which is infrequently reported in literature. Many of these diets and supplements may seem harmless, but as our case illustrates, when combined with other risk factors, patients can face adverse effects and even hospitalization. It is imperative that such dietary practices are physician supervised to avoid complications. With the recent surge of over-the-counter weight loss supplements and fat diets, physicians need to engage in dietary discussion with patients when attempting to lose weight.

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“…Acetic acid is commonly used to decrease the pH of a chitosan solution, which increases the solubility of chitosan in the solution [ 63 , 64 ]. However, acetic acid is considered a hazardous solvent [ 64 , 65 ]. Alternatively, Cui et al [ 66 ] used an ionic liquid (IL), 1-ethyl-3-methylimidazolium acetate ([EMIM]AC), in order to dissolve chitosan and prepare membranes.…”

Section: Membrane Fabricationmentioning

confidence: 99%

Polymers and Solvents Used in Membrane Fabrication: A Review Focusing on Sustainable Membrane Development

et al. 2021

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(1) Different methods have been applied to fabricate polymeric membranes with non-solvent induced phase separation (NIPS) being one of the mostly widely used. In NIPS, a solvent or solvent blend is required to dissolve a polymer or polymer blend. N-methyl-2-pyrrolidone (NMP), dimethylacetamide (DMAc), dimethylformamide (DMF) and other petroleum-derived solvents are commonly used to dissolve some petroleum-based polymers. However, these components may have negative impacts on the environment and human health. Therefore, using greener and less toxic components is of great interest for increasing membrane fabrication sustainability. The chemical structure of membranes is not affected by the use of different solvents, polymers, or by the differences in fabrication scale. On the other hand, membrane pore structures and surface roughness can change due to differences in diffusion rates associated with different solvents/co-solvents diffusing into the non-solvent and with differences in evaporation time. (2) Therefore, in this review, solvents and polymers involved in the manufacturing process of membranes are proposed to be replaced by greener/less toxic alternatives. The methods and feasibility of scaling up green polymeric membrane manufacturing are also examined.

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Successful management of 70% acetic acid ingestion on the intensive care unit: A case report

Cited by 12 publications

References 18 publications

Clinical and pathologic features of acute bovine liver disease in Australia

Clinical and pathologic features of acute bovine liver disease in Australia

Severe Metabolic Acidosis: A Case of Triple Hit with Ketogenic Diet, Vinegar, and Metformin in an Obese Patient

Polymers and Solvents Used in Membrane Fabrication: A Review Focusing on Sustainable Membrane Development

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