This article provides a comparative description of changes in the level of growth hormone and blood cortisol in adolescents with the development of meningitis of various etiologies. The study was conducted in 2019 on 48 patients aged 10 to 19 years. In comparison, the groups of patients with acute bacterial and serous meningitis are presented. The results of the study help to determine what metabolic disorders can occur with meningitis of various etiological agents, which aggravates the course of the disease, increases the risk of complications and death, as well as to build a tactics of treatment and management of such patients. Particular attention is paid to the development of stress hyperglycemia — a condition that significantly aggravates the course of a generalized infectious and inflammatory process and increases the risk of complications from many body systems.