The clinical and epidemiological features of the course of acute bacterial meningitis in various age groups of patients in the period from 2014 to 2018 are described. An analysis of 398 case histories of patients was performed. Patients were divided into 5 age groups. The inclusion criterion is the presence of bacterial meningitis of any etiology. Patients with serious meningitis of viral and tuberculous etiology were excluded. Statistical processing was carried out using the SPSS program (determination of compliance with Gauss law, descriptive statistics, determination of average values, relationships between disease indicators, Bonferroni correction). Risk factors were determined, the course of neuro infection in various age groups was revealed, the criteria and the timing of the diagnosis of meningitis.

This article provides a comparative description of changes in the level of growth hormone and blood cortisol in adolescents with the development of meningitis of various etiologies. The study was conducted in 2019 on 48 patients aged 10 to 19 years. In comparison, the groups of patients with acute bacterial and serous meningitis are presented. The results of the study help to determine what metabolic disorders can occur with meningitis of various etiological agents, which aggravates the course of the disease, increases the risk of complications and death, as well as to build a tactics of treatment and management of such patients. Particular attention is paid to the development of stress hyperglycemia — a condition that significantly aggravates the course of a generalized infectious and inflammatory process and increases the risk of complications from many body systems.

This article highlights the nature of the immune response in patients with acute bacterial meningitis in adolescents. Immunological examination was carried out in the acute period of the disease in patients aged 10 to 19 years. The hemogram, the nature of the cellular and humoral immune response, as well as the development of pro-inflammatory defense factors, C-reactive protein, and procalcitonin were used to evaluate the main components of the immune system.