Clinical and epidemiological profile of cleft lip and palate patients in Peru, 2006 – 2019

Peña-Soto, Claudio; Arriola-Guillén, Luis Ernesto; Díaz-Suyo, Antonio; Flores-Fraile, Javier

doi:10.4317/jced.58976

Cited by 6 publications

(5 citation statements)

References 21 publications

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“…The analysis of blood samples from non-syndromic children with CL, CLP and CP revealed genomic sequences previously linked to OFCs and new (250) sequences, with different methylation occurring in the embryonic period [ 17 ]. These results support the hypothesis that the three subtypes may have different aetiology [ 3 , 18 ].…”

Section: Introductionsupporting

confidence: 88%

Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review

Inchingolo

Fatone²,

Malcangi

et al. 2022

Children

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OFCs (orofacial clefts) are among the most frequent congenital defects, but their etiology has yet to be clarified. OFCs affect different structures and functions with social, psychological and economic implications in children and their families. Identifying modifiable risk factors is mandatory to prevent the occurrence of non-syndromic OFCs (NSOFCs). PubMed, Cochrane Library, Scopus and Web of Science were searched from 1 January 2012 to 25 May 2022 and a total of 7668 publications were identified. Studies focusing on the risk factors of NSOFCs were selected, leading to 62 case-control and randomized clinical trials. Risk factors were categorized into non-modifiable and modifiable. The first group includes genetic polymorphisms, gender of the newborn, ethnicity, and familiarity. Within the second group, risk factors that can only be modified before conception (consanguinity, parental age at conception, socio-economical and educational level, area of residency and climate), and risk factors modifiable before and after conception (weight, nutritional state, acute and chronic diseases, psychophysical stress, licit and illicit drugs, alcohol, smoke, pollutants and contaminants) have been distinguished. This study provides a wide overview of the risk factors of NSOFCs, focusing on modifiable ones, to suggest new perspectives in education, prevention, medical interventions and clinical research.

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Section: Introductionsupporting

confidence: 88%

Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review

Inchingolo

Fatone²,

Malcangi

et al. 2022

Children

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“…[7] In another study conducted in Peru, [15] cleft palate was unilateral (309 out of 3923), while bilateral was (154 out of 3923). [15] Our findings that mothers aged 35 or more are at higher risk of cleft palate go in line with a previous study. [5] In contrast, a Nigerian study [16] showed age <25 was associated with a higher risk of having a child with a cleft defect.…”

Section: Discussionmentioning

confidence: 97%

“…In comparison to a previous study conducted in the Kingdom of Saudi Arabia, [ 7 ] the number of patients with unilateral cleft palate was 14 out of 130 with an estimated rate of 11%, while bilateral was 11 out of 130 with an estimated rate of 8%. [ 7 ] In another study conducted in Peru, [ 15 ] cleft palate was unilateral (309 out of 3923), while bilateral was (154 out of 3923). [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

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Cleft lip and palate risk factors among otorhinolaryngology: Head and neck surgery patients in two hospitals

Darjazini Nahas,

Hmadieh,

Audeh

et al. 2023

Medicine

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Cleft lip and/or palate is the most prevalent type of head and neck deformity, accounting for 65% of cases. The occurrence of this condition is influenced by both genetic and environmental factors. Cleft defects are classified into 2 types: syndromic cleft lip and palate syndrome and non-syndromic cleft lip and palate syndrome. Cleft lip with or without cleft palate is the most common type of cleft defect, and the surgical repair is the primary treatment option for patients. Our study was a retrospective case–control study that included 132 cases of patients with cleft defects and 132 healthy babies without cleft defects serving as controls. Personal information, including the name, age, and origin of the participants, was collected. Additionally, we collected information on all potential risk factors, including medical history, daily habits, consanguinity between parents, and family history. Information was collected in Excel and analyzed using the Statistical Package for Social Sciences and a Chi-Square test was performed to determine the results and their relationship to cleft lip and palate. Our study identified various risk factors that have a significant association with cleft lip and palate with a P-value <5% in addition to factors that are not considered risk factors. Using relative risk analysis, we were able to rank the top 5 most significant and influential risk factors. The most impactful factor was not taking folic acid during pregnancy. The primary risk factors associated with cleft lip and palate include a family history of the condition, lack of folic acid supplementation, maternal age over 35 years, and high temperatures exceeding 39 °C. Consequently, we recommend that mothers who intend to conceive should take folic acid supplements at a dose of 0.4 to 0.8 mg during the initial trimester of pregnancy. Additionally, we advise careful monitoring of all risk factors, particularly during the first trimester of pregnancy.

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“…40,41 The oral and dental problems that occur in these patients are characterized by dental anomalies in addition to scarring results of orthopedic and early maxillary surgery that interfere with proper oral hygiene maneuvers and consequently increase the risk of dental caries and periodontal disease. In view of the above, it is important that students about to graduate and dental professionals have knowledge of preventive strategies (dietary patterns, oral hygiene, use of sealants and varnishes, among others) [42][43][44][45] as well as criteria for the proper diagnosis and treatment of patients with CLP in order to avoid oral problems that compromise their general health. The evaluation of knowledge in this regard is an essential tool to improve the performance of students as it evidences their preparation for the clinical field in this topic.…”

Section: Discussionmentioning

confidence: 99%

Sociodemographic Factors Associated with Knowledge About Management of Cleft Lip and Palate Patients in Peruvian Dental Students: A Logistic Regression Analysis

Luyo-Peñafiel,

Briceño-Vergel,

Ladera-Castañeda

et al. 2023

AMEP

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Background: Cleft lip and palate are relatively frequent craniofacial alterations caused by the lack of union of the frontonasal processes with the maxillary processes during the first weeks of intrauterine life. This study evaluated the sociodemographic factors associated with the level of knowledge about management of cleft lip and palate (CLP) patients in Peruvian dental students. Methods: This analytical, observational, cross-sectional and prospective study evaluated 191 dental students belonging to two branches of a private Peruvian university (one branch in the capital city and the other in a province), from September to November 2022. A validated questionnaire of 14 closed multiple-choice questions was used. A logit model was used to evaluate the influence of the variables: sex, age, academic year of study, marital status, relationship with CLP persons, place of origin and area of residence, on the level of knowledge of the students considering a significance level of p<0.05. Results: Of the total, 77%, 22.5% and 0.5% presented a poor, fair and good level of knowledge, respectively, on the dental management of the patient with cleft lip and palate. In addition, those who lived in urban areas were 2.8 times more likely to have poor knowledge about the dental management of patients with CLP, compared to those who lived in non-urban areas (OR = 2.83; 95% CI: 1.26-6.33). Finally, sex, age, marital status, place of origin, academic year of studies and relationship with CLP persons were not considered influential factors (p>0.05). Conclusion: Most of the students showed a poor level of knowledge about the dental management of patients with cleft lip and palate, a risk factor being that the students live in an urban area. It is recommended that educational authorities include selected topics on CLP in subjects related to infant, child and adolescent care.

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Clinical and epidemiological profile of cleft lip and palate patients in Peru, 2006 – 2019

Cited by 6 publications

References 21 publications

Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review

Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review

Cleft lip and palate risk factors among otorhinolaryngology: Head and neck surgery patients in two hospitals

Sociodemographic Factors Associated with Knowledge About Management of Cleft Lip and Palate Patients in Peruvian Dental Students: A Logistic Regression Analysis

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