Clinical and etiological characteristic, classification and treatment of aseptic corneal ulcers

Brzheskaya, I.V.; Вячеславовна, Бржеская Ирина; Somov, E.E; Евгеньевич, Сомов Евгений

doi:10.17816/ov11125-33

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…Trauma was most common causative factor 486(81%) this finding is supported by the work of Musch DC, Sugar A, Meyer RF et al and Titiyal JS, Negi S, Anand A, Tandon R, Sharma N, Vajpayee RB et al [16,17] . Most of the ulcer were 3 mm to 6 mm in size and Paracentral in location, this finding is similsr to the study of Mascarenhas J, Srinivasan M, Chen M, Rajaraman R, Ravindran M et al, Khare P, Shrivastava M, Kumar K et al and Brzheskaya I.V., Somov E.E [13,18,19] . Corneal ulcer associated with hypopyon in 22(12.5%) patients.…”

Section: Discussionsupporting

confidence: 83%

Microbiological profile and antimicrobial sensitivity pattern of culture positive bacterial keratitis: A prospective observational study

Satish¹,

M²,

Acharya³

2021

Int. J. Med. Ophthalmol.

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Background: Microbial keratitis is suppurative infection of cornea considered as emergency and potential threat to vision. Prompt diagnosis and treatment of microbial keratitis is required to prevent complication and blindness. So present study has been designed to determine bacteriological profile and sensitivity pattern of culture positive bacterial keratitis, risk factor associated it and treatment outcome. Material and Method: After enrolment of patients a detailed relevant history of patients regarding to mode of injury and predisposing factor were recorded and detailed clinical examination was done. Visual acuity of all patients was tested. Slit lamp biomicroscopy was performed and Corneal ulcer was examined properly. Under local anaesthesia with 4% lignocaine corneal scrap was taken from edge and base of ulcer. Sample was sent for gram stain, 10% KOH wet mount preparation, blood agar and Sabouraud's dextrose agar. Result: In present study out of 600 specimen 460(76.66%) patients were culture positive out of them 47.33% were fungal and remaining were bacterial(29.33%). Regarding bacteriological profile of culture positive corneal ulcer, we have observed that gram positive bacteria were common than gram negative. Among all staphylococcus aureus was common organism 54(30.68%). Discussion and Conclusion:From present study we can conclude that bacterial corneal ulcer is less common than funga ulcer. Regarding bacteriological profile of culture positive corneal ulcer, we have observed that gram positive bacteria were common than gram negative. Among all staphylococcus aureus was common organism followed by pseudomonas. Regarding sensitivity of common organism isolated staphylococcus was 100% sensitive to vancomycin and azithromycin, sensitivity to fluoroquinolones were from 60 % to 80 %. More than 80% pseudomonas was sensitive to fluoroquinolones and aminoglycosides. 77.27% patients were recovered at final follow up.

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Section: Discussionsupporting

confidence: 83%

Microbiological profile and antimicrobial sensitivity pattern of culture positive bacterial keratitis: A prospective observational study

Satish¹,

M²,

Acharya³

2021

Int. J. Med. Ophthalmol.

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“…According to WHO, blindness secondary to corneal disorders is one of the leading causes of loss of sight [ 12 ]. Each year, 1.5–2.0 million cases of monocular blindness secondary to various corneal lesions are documented worldwide [ 13 , 14 ]. The most frequent causes of corneal lesions include keratitis and corneal ulcers [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Concerning corneal ulcers in particular, the available clinical experience showed that they are a group of rare but very serious conditions, which are difficult to manage. For example, according to a number of authors, anatomical destruction of the eye is the ultimate outcome in 8-9% of the cases, and in 17% of the cases, enucleation is undertaken due to lack of treatment effect [ 13 ]. Corneal damage leading to corneal ulceration occurs as a combination of direct microbial invasion and a release of collagenases, secondary to host chemotaxis of leukocytes [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of therapeutic keratoplasty using corneal xenografts in patients with corneal ulcers

Turchyn

Krynytska

Кліщ

2019

rjo

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Objective. to assess the clinical efficacy of keratoplasty using a corneal xenograft in patients with corneal ulcers of various etiologies.Methods. A total of 46 patients (49 eyes) with complicated corneal ulcers (perforated or with impending perforation) have been operated. Freeze-dried corneal xenografts have been used for keratoplasty.Results. Our results showed that postoperative period after xenogeneic keratoplasty in patients with corneal ulcers was uneventful and the transplant underwent gradual resorption. In all patients with non-infected corneal erosions, ulcers healed completely and corneal fistulas were fully closed. The implanted corneal xenograft undergoes complete resorption between 2 to 3 months.Conclusions. Given the shortages of donor material, the demonstrated efficacy of using corneal xenografts in patients with complicated corneal ulcers requiring therapeutic keratoplasty allows recommending corneal xenografts for wide use to relieve inflammation and to preserve the eye.

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“…Local disorders include herpetic keratitis and paralytic lagophthalmos) leading to severe trophic impairments in the cornea. 9 The most common location for ulcers is the central cornea with >6 mm in size.…”

Section: Clinical Features Of Corneal Ulcer Patientsmentioning

confidence: 99%

Microbiological Profile of Corneal Ulcer in Dr. Mohammad Hoesin General Hospital Palembang, Indonesia: July to September 2021

Aziztama

Tribowo

2022

sjo

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Introduction: Microbial agents cause infectious processes, which may result in corneal inflammation leading to corneal necrosis, ulceration, and perforation. This disorder is one of the major etiologies of monocular blindness in developing countries in Asia, Africa, and the Middle East. The etiology of corneal ulcers varies in different regions. Methods: This research is a descriptive study approach. Data obtained from the medical records of patients who were registered as corneal ulcer patients in Dr. Mohammad Hoesin Palembang from July 2021 to September 2021. Results: A total of 9 patients were diagnosed with a corneal ulcer. The number of corneal ulcer patients was more in male patients (77.8%). The age of patients varies from 16 years to 63 years, and most elderly patients are diagnosed with this condition. Predisposing factors are unknown in most patients. The most common location for ulcers is the central cornea (88.9%), with >6 mm in size. Hypopyon is found in 2 patients (22.2%), while perforation and corneal melting in 1 patient consecutively. The most common microbiological profiles of corneal ulcer patients in this study are unspecified (66.7%), while ulcers due to bacteria in the second place of the microbiological profile (33.3%) consist of Enterobacter aerogenes, Staphylococcus epidermidis, and Pantoea spp and sensitive to almost all kinds of antibiotics. Conclusion: The most common microbiological profiles of corneal ulcer patients in this study are unspecified, while ulcer due to bacteria in the second place of the microbiological profile consists of Enterobacter aerogenes, Staphylococcus epidermidis, and Pantoea spp and sensitive to almost all kinds of antibiotics.

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Clinical and etiological characteristic, classification and treatment of aseptic corneal ulcers

Cited by 3 publications

References 10 publications

Microbiological profile and antimicrobial sensitivity pattern of culture positive bacterial keratitis: A prospective observational study

Microbiological profile and antimicrobial sensitivity pattern of culture positive bacterial keratitis: A prospective observational study

Clinical efficacy of therapeutic keratoplasty using corneal xenografts in patients with corneal ulcers

Microbiological Profile of Corneal Ulcer in Dr. Mohammad Hoesin General Hospital Palembang, Indonesia: July to September 2021

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