Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review

Ho, Chung Liang; Wu, Chiu-Yen; Chen, Jeff Yi‐Fu; Wu, Chieh‐Shan

doi:10.3390/genes14071362

Cited by 13 publications

(3 citation statements)

References 119 publications

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“…However, the difference was not statistically significant. Hair loss continues to be one of the well-known symptoms of thyroid dysregulation, in cases of both deficient and excessive levels of thyroid hormones [31][32][33]. It is postulated that thyroid hormone signaling is necessary for correct stem cell activation from the hair bulge, and improper stem cell signaling may be associated with hair loss.…”

Section: Discussionmentioning

confidence: 99%

Non-Cicatricial Alopecia and Its Association with Anthropometric Measurements and Nutritional Laboratory Markers

Wróblewska-Kończalik,

Pawlaczyk,

Kolasiński

et al. 2024

Life

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Alopecia constitutes one of the most common dermatological disorders, and its steadily increasing prevalence is a cause for concern. Alopecia can be divided into two main categories, cicatricial/scarring and non-cicatricial/non-scarring, depending on the causes of hair loss and its patterns. The aim of this study was to investigate the relationship between anthropometric and nutritional laboratory parameters in Caucasian adult women and men with non-cicatricial alopecia. A total of 50 patients (37 with non-cicatricial alopecia and 13 healthy controls) were included in the study. Clinical examination and scalp trichoscopy were performed. The anthropometric and nutritional laboratory parameters were collected and analyzed. No statistically significant differences in the laboratory findings were found. The patients with non-cicatricial alopecia were statistically significantly younger as compared to the controls. An elevated risk of hair loss, which was detected among the younger participants, might be associated with a modern lifestyle and the so-called ‘Western diet’. It seems safe to assume that suboptimal nutrition and poor eating habits during childhood might constitute risk factors for early hair loss.

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Section: Discussionmentioning

confidence: 99%

Non-Cicatricial Alopecia and Its Association with Anthropometric Measurements and Nutritional Laboratory Markers

Wróblewska-Kończalik,

Pawlaczyk,

Kolasiński

et al. 2024

Life

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“…The exclusion criteria were patients with autoimmune diseases. 35–37 Exclusion of the above cases left a dataset containing 8167 controls and 408 cases of AA. All results can be found at: https://my.locuszoom.org/gwas/398185/?token=15220589b5234108b60edff3dcc5eaee .…”

Section: Methodsmentioning

confidence: 99%

Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles

Yang,

Liu,

Chen

et al. 2023

CCID

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Purpose Alopecia areata (AA) is one of the most prevalent autoimmune diseases affecting humans. Given that hair follicles are immune-privileged, autoimmunity can result in disfiguring hair loss. However, the genetic basis for AA in the Taiwanese population remains unknown. Materials and Methods A genome-wide association study was conducted using a cohort of 408 AA cases and 8167 controls. To link variants to gene relationships, we used 882 SNPs (P<1E-05) within 74 genes that were associated with AA group to build the biological networks by IPA software. HLA diplotypes and haplotypes were analyzed using Attribute Bagging (HIBAG)-R package and chi-square analysis. Results Seven single nucleotide polymorphisms (SNPs) including LINC02006 (rs531166736, rs187306735), APC (rs112800832_C_CAT), SRP19 (rs139948960, rs144784670), EGFLAM (rs16903975) and LDLRAD3 (rs79874564) were closely associated with the AA phenotype (P<5E-08). Examination of biological networks revealed that these genomic areas are associated with antigen presentation signaling, B cell and T cell development, Th1 and Th2 activation pathways, Notch signaling, crosstalk signaling between dendritic cells and natural killer cells, and phagosome maturation. Based on human leukocyte antigen (HLA) genotype analysis, four HLA genotypes (HLA-B*15:01-*40:01, HLA-DQA1*01:02-*03:03, HLA-DQA1*01:02, and HLA-DQB1*02:01) were found to be associated with AA (adjusted p-value<0.05). HLA-DQA1*01:02 is the most significantly related gene in the Taiwanese population (adjusted p-value = 2.09E-05). Conclusion This study successfully identified susceptibility loci associated with AA in the Taiwanese population. These findings not only shed light on the origins of AA within the Taiwanese context but also contribute to a comprehensive understanding of the genetic factors influencing AA susceptibility.

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“…Alopecia areata (AA) is an autoimmune disease characterised by the partial or complete sudden loss of hair from the scalp or other hairy parts of the body without scarring [130]. The fact that scarring is not observed in the course of this dermatosis is related to the fact that the hair follicle is not destroyed, but preserved [131].…”

Section: Alopecia Areatamentioning

confidence: 99%

The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases

Ryguła,

Pikiewicz,

Grabarek

et al. 2024

IJMS

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Dermatoses are an increasingly common problem, particularly in developed countries. The causes of this phenomenon include genetic factors and environmental elements. More and more scientific reports suggest that the gut microbiome, more specifically its dysbiosis, also plays an important role in the induction and progression of diseases, including dermatological diseases. The gut microbiome is recognised as the largest endocrine organ, and has a key function in maintaining human homeostasis. In this review, the authors will take a close look at the link between the gut–skin axis and the pathogenesis of dermatoses such as atopic dermatitis, psoriasis, alopecia areata, and acne. The authors will also focus on the role of probiotics in remodelling the microbiome and the alleviation of dermatoses.

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Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review

Cited by 13 publications

References 119 publications

Non-Cicatricial Alopecia and Its Association with Anthropometric Measurements and Nutritional Laboratory Markers

Non-Cicatricial Alopecia and Its Association with Anthropometric Measurements and Nutritional Laboratory Markers

Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles

The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases

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