Clinical and haematological responses of feline blood donors anaesthetised with a tiletamine and zolazepam combination

Abstract

This prospective study investigated the effect on clinical and haematological variables of the anaesthetic combination of tiletamine and zolazepam in feline blood donors. Blood (10 ml/kg bodyweight to a maximum volume of 60 ml) was collected from the jugular vein of 31 owned healthy cats anaesthetised with 2.5 mg/kg of tiletamine and 2.5 mg/kg of zolazepam intramuscularly. Rectal temperature (RT), systolic arterial pressure (SAP), mean arterial pressure (MAP), diastolic arterial pressure (DAP), heart rate (HR) and complete blood count (including red blood cells [RBC], haemoglobin [HB], haematocrit [HT], platelet [PLT] count, white blood cells [WBC], lymphocytes, neutrophils, eosinophils, monocytes and basophils) were evaluated pre- and postdonation. RT decreased significantly (P <0.01) after blood donation (mean change in RT -0.7°C). Significant increases in SAP (P = 0.03), MAP (P <0.01) and DAP (P <0.01) occurred after blood donation (mean increase 13 mmHg, 12 mmHg and 11 mmHg, respectively). Although RBC, HT, HB, WBC, PLT, neutrophil and monocyte counts decreased, and HR, and lymphocyte, eosinophil and basophil counts increased after blood donation this change was not statistically significant. Mean time from pre- to postdonation evaluation was 39 ± 11 mins (range 24-76 mins). None of the cats had evidence of pallor or collapse after recovery from anaesthesia. The collection of blood at 10 ml/kg bodyweight to a maximum volume of 60 ml in healthy cats using a low dose tiletamine and zolazepam anaesthetic appears to be well tolerated by feline blood donors.

Kedilerde İntranasal ve İntramusküler Zolazepam-Tiletamine Kombinasyonu Uygulamasının Karşılaştırılması

“…It has been stated that RT has tendency to decrease after administration of ZT combination due to muscle relaxation (13). In this study, RT decreased following the administration of ZT combination in both routes, which is consistent with previous report that used IM 2.5 mg/kg Zoletil in cats for sedation (14). In our study, SpO2 value was not significantly different between groups.…”

In vitro assessment of quality of citrate‐phosphate‐dextrose‐adenine‐1 preserved feline blood collected by a commercial closed system

“…There are various sedation and anesthesiologic protocols for feline blood donation . We chose an association of alfaxalone, midazolam, and butorphanol.…”

“…There are various sedation and anesthesiologic protocols for feline blood donation. 3,18,[25][26][27] We chose an association of alfaxalone, midazolam, and butorphanol. In our study, the chosen protocol allowed a In both human and veterinary medicine, bacterial contamination of blood products is still the most prevalent infectious risk in transfusion medicine.…”

Retrospective evaluation of unexpected events during collection of blood donations performed with and without sedation in cats (2010–2013)

“…Iazbik et al studied feline blood donors anesthetized with sevoflurane and found that their heart rate and blood pressure decreased significantly following blood donation, but did not report any adverse effects of this sedation . A final report described the use of a proprietary combination of tiletamine and zolazepam for sedation of feline blood donors and found that rectal temperature significantly decreased and blood pressure significantly increased following donation, but there were no instances of pallor or collapse after recovery from sedation . Although the cardiovascular effects seen in these studies appear minor, they are present, as are the risk of adverse effects (some of which may not have been detected in these studies) resulting in death.…”