Clinical and hemodynamic features of Eisenmenger syndrome patients at the time of first admission: a tertiary referral-center experience

Abstract

Bu çalışmanın özeti, 21-24 Mayıs 2011 tarihlerinde Gothenburg -Sweden'da yapılan ESC Heart Failure Kongresi'nde poster bildirisi olarak sunulmuştur. ABSTRACTObjective: In this study, patients admitted with the diagnosis of Eisenmenger syndrome (ES) in a tertiary referral center were analyzed. Methods: The data of 20 consecutive patients (mean age: 27.6+1.8 years, 7 male and mean follow-up time: 35.6±9.1 months) with ES were retrospectively analyzed. Demographic characteristics, symptoms, physical examination, laboratory and hemodynamic parameters were analyzed at the time of first admission.Results: The most frequent underlying heart diseases were ventricular septal defect (VSD) with complex congenital disease (n:8, 40%) and isolated VSD (n:7, 35%). 6-minute walking test distance was 347.9±33.7 meters and 15 patients (75%) had a functional capacity of NYHA Class III, at the time of admission. ES was diagnosed with catheterization in all patients and mean systolic pulmonary arterial pressure measured by catheterization was 112±6.8 mmHg. Pulmonary function tests, FVC (forced vital capacity), FEV 1 (forced expiratory volume), FEV 1 /FVC values were respectively, 3.1±0.4, 2.5±0.4 L and 76.7±3.3%. Metabolic tests were performed in all patients at the first visit. Mean VO2 max was 16.7 ±1.0 ml / kg/min and VE/VCO2 rate was 53.9±3.2%. Although PH and partial pressure of carbon dioxide levels were within normal range in blood gas analysis, oxygen saturation and partial pressure of oxygen levels were low. Conclusion:The most common underlying heart disease of ES patients is VSD. In this cases exercise capacity is restricted and this restriction is reflected in laboratory parameters. (

Registry of Patients With Pulmonary Hypertension Presented to Ain-Shams University Hospitals

“…In our study, the mean 6MWT was 218.75 meters ± 65.58 (range 120-340) in adult patients with Eisenmenger syndrome This was lower than a study conducted by Güngör et al who reported that mean 6MWD was 347 meters in patients with Eisenmenger syndrome (10) . This was lower also form the mean 6MWT from REHAB registry which was 370.0 meters (280.0-451.5) (6) .…”

Six-minute walk test in pulmonary arterial hypertension

“…In a study from Turkey, the mean 6MWD was found to be 184 m with the highest values (201 m) observed in the patient group with PAH associated with congenital heart disease and the lowest value (159 m) observed in the patient group in PAH associated with connective tissue diseases ( 16 ). In another study, Güngör et al ( 17 ) reported that mean 6MWD was 347 m in patients with Eisenmenger syndrome.…”