Clinical and histological evaluation on application of platelet concentrates on depigmented gingival epithelium

Abstract

Background:The platelet concentrate is a windfall in the field of regenerative therapy in periodontology. It accelerates wound healing by excellent neovascularization and promoting fast cicatricle tissue remodeling.Aim:This study aims to evaluate clinically and histologically accelerated effect of platelet-rich fibrin (PRF) membrane and PRF matrix (PRFM) following depigmentation procedure.Materials and Methods:Eleven individuals were divided into three groups after depigmentation procedure. PRF membrane and PRFM gel were prepared as per standard protocol. Group A and B received PRF membrane and PRFM gel followed by periodontal dressing, respectively, and the only periodontal dressing was placed in Group C. The individuals were evaluated for visual analog scale (VAS) and healing index (HI) on 3rd and 5th day. Epithelization test and histologic analysis from punch biopsy were done on the 5th day. At 3rd month, reevaluation was performed.Results:The intergroup statistical analysis in respect to VAS, HI, epithelization test, and histologic analysis showed a statistically significant results with P < 0.001 in Groups A and B compared to Group C. Clinical evaluation of epithelization test and histologic analysis revealed better-wound healing and moderate to no inflammatory cell infiltrate in Groups A and B, respectively, as compared to Group C, which appeared more erythematous with dense inflammatory cells.Conclusion:Thus, the application of PRF membrane and PRFM gel has shown a successful approach to protect the raw wound area of depigmented sites with better patient comfort and faster healing.

Clinical and histological comparison of platelet-rich fibrin versus non-eugenol periodontal dressing in the treatment of gingival hyperpigmentation

“…They used PRF, PRF matrix (PRFM), and periodontal pack and the use of PRF was found to be superior as compared to PRFM and periodontal pack. [31] PRF group produced better results as release of GFs occurs in a steady manner over a period of 10 days whereas in first-generation PCs (PRFM), there is a rapid release of GFs as observed in our study group.…”

Biological and Mechanical Properties of Platelet-Rich Fibrin Membranes after Thermal Manipulation and Preparation in a Single-Syringe Closed System

“…The application of PRF membrane in oral and maxillofacial surgery is widespread, however, the right application of PRF and the outcome of the surgery also depends on the preparation method of the membrane, and also from the ability of surgeons, and from the complexity of the operation [ 22 , 23 , 24 , 25 , 26 ]. The membrane is capable of increasing the adhesion and proliferation capacity of gingival fibroblasts, thus PRF membrane is suitable for periodontal regeneration [ 27 , 28 , 29 ].…”

Despigmentación gingival mediante mucoabrasion en el sector anterior. Reporte de caso

“…Nuestra experiencia con los casos tratados confirma la practicidad y la simplicidad de la mucoabrasión, además de obtener resultados favorables en corto tiempo. La técnica también puede ser combinada con Plasma Rico en Fibrina (PRF) para acelerar el proceso de cicatrización [11][12][13] . Se considera que remover estas manchas permite mejorar la apariencia y la sonrisa del paciente; una sonrisa estética no solo crea un impacto en los espectadores, sino que también mejora la personalidad y la autoconfianza del individuo 14 .…”