Clinical and histological prognostic factors in locally advanced oral cavity cancers treated with primary surgery

Noël, Vincent; Dassonville, O.; Chamorey, Emmanuel; Poissonnet, G.; Pierre, C.; Nao, E.-E.-M.; Peyrade, Fréd́eric; Bénézery, Karen; Viel, Dangelo Odair; Sudaka, Anne; Marcy, Pierre-Yves; Vallicioni, J; Démard, F; Santini, J; Bozec, Alexandre

doi:10.1016/j.anorl.2012.01.004

Cited by 17 publications

(8 citation statements)

References 19 publications

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“…Patient characteristics and related prognostic factors were in line with those reported in the literature in OCSCC. 29 , 30 Around two-thirds of patients in our series had locally advanced OCSCC with pathological stage III or IV disease. Association with both DFS and OS was consistent with the literature.…”

Section: Discussionmentioning

confidence: 80%

Prognostic value of tumor mutational burden in patients with oral cavity squamous cell carcinoma treated with upfront surgery

et al. 2021

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Background Oral cavity is the most prevalent site of head and neck squamous cell carcinomas (HNSCCs). Most often diagnosed at a locally advanced stage, treatment is multimodal with surgery as the cornerstone. The aim of this study was to explore the molecular landscape of a homogenous cohort of oral cavity squamous cell carcinomas (OCSCCs), and to assess the prognostic value of tumor mutational burden (TMB), along with classical molecular and clinical parameters. Patients and methods One hundred and fifty-one consecutive patients with OCSCC treated with upfront surgery at the Institut Curie were analyzed. Sequencing of tumor DNA from frozen specimens was carried out using an in-house targeted next-generation sequencing panel (571 genes). The impact of molecular alterations and TMB on disease-free survival (DFS) and overall survival (OS) was evaluated in univariate and multivariate analyses. Results Pathological tumor stage, extranodal spread, vascular emboli, and perineural invasion were associated with both DFS and OS. TP53 was the most mutated gene (71%). Other frequent molecular alterations included the TERT promoter (50%), CDKN2A (25%), FAT1 (17%), PIK3CA (14%), and NOTCH1 (15%) genes. Transforming growth factor-β pathway alterations (4%) were associated with poor OS ( P = 0.01) and DFS ( P = 0.02) in univariate and multivariate analyses. High TMB was associated with prolonged OS ( P = 0.01 and P = 0.02, in the highest 10% and 20% TMB values, respectively), but not with DFS. Correlation of TMB with OS remained significant in multivariate analysis ( P = 0.01 and P = 0.005 in the highest 10% and 20% TMB values, respectively). Pathological tumor stage combined with high TMB was associated with good prognosis. Conclusion Our results suggest that a high TMB is associated with a favorable prognosis in patients with OCSCC treated with upfront surgery.

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Section: Discussionmentioning

confidence: 80%

Prognostic value of tumor mutational burden in patients with oral cavity squamous cell carcinoma treated with upfront surgery

et al. 2021

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“…The staging of OSCC based on American Joint Committee on Cancer (AJCC) TNM system has been used for several years to estimate OSCC patients' survival in clinical practice 7 . However, the traditional TNM staging system is often inadequate as the prognosis of OSCC varies on a number of factors that are related to not only the tumor size, distant metastasis and nodal status, but also to the other clinical pathological features such as tumor site, tumor grade, nodal involvement, and presence of lymphovascular invasion, as well as to the patient speci c characteristics such as age, smoking and comorbidities 8 . Hence, the consideration of prognostic relevant clinical-pathologic factors could offer accurate prognostic information.…”

Section: Introductionmentioning

confidence: 99%

Nomograms to Predict the Prognosis in Locally Advanced Oral Squamous Cell Carcinoma After Curative Resection

Nie

Zhao

Shang³

et al. 2021

Preprint

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Background: Oral squamous cell carcinoma (OSCC), the dominant histologic type of oral cancer. Locally advanced OSCC remains a major therapeutic challenge. Our study aimed to develop and validate nomograms predicting survival prognosis in patients with locally advanced oral squamous cell carcinoma (OSCC) after curative resection. Methods: A total of 269 consecutive patients with primary OSCC who received curative resection between September 2007 and March 2020 were retrospectively enrolled in our study. Patients were randomly assigned to the training cohort (n=201) or the validation cohort (n=68). Multivariate Cox regression analyses were conducted to determine independent prognostic factors for overall survival (OS) and cancer specific survival (CSS) in the training set, which were used for the construction of nomogram models estimating 3-, and 5-year OS and CSS. We also evaluated the nomograms using concordance indices (c-index), calibration curves, and decision curve analyses (DCA), and compared those with the AJCC 8th staging system. The results were externally validated in the validation cohort.Results: Age, Kaplan-Feinstein (KFI) index, pT, the number of positive nodes and systemic inflammatory index (SII) were significant prognostic predictors for OS and CSS. The OS nomogram had c-index values of 0.712 in the training set and 0.697 in the validation set, while the CSS nomograms had c-index values of 0.709 in the training set and 0.675 in the validation set. These data were superior to those of AJCC 8th staging system, suggesting high discriminative ability of the nomograms. Calibration curves exhibited good agreement between observed and predicted survival. DCA curves indicated the nomograms were with potential clinical usefulness. These results were validated in the validation set.Conclusions: The novel nomograms incorporating clinically available characteristics for OS and CSS prediction were developed in the locally advanced OSCC patients after curative surgery. Validation revealed good discrimination and calibration, indicating the clinical utility of the nomograms in the individualized prognosis prediction of locally advanced OSCC after curative surgery.

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“…Mandible infiltration can be of periosteal fixation, cortical erosion, or medullary invasion. Deeper invasion has poor prognosis [35]…”

Section: Bone Invasionmentioning

confidence: 99%

Oral Squamous Cell Carcinoma: Diagnosis and Treatment Planning

Deshmukh

Shekar

2021

Oral and Maxillofacial Surgery for the Clinician

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The incidence of Oral Squamous Cell Carcinoma (OSCC) is on the rise. Association with tobacco and alcohol is well established. Transformation rates in premalignant lesions and conditions vary in the available literature. Oral cancer in other parts of the world has different etiology in contrast to Indian oral cancer. Because of this Indian OSCC may require different parameters for treatment than that of the other oral cancer. Its prognosis also may not be comparable to others.

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Clinical and histological prognostic factors in locally advanced oral cavity cancers treated with primary surgery

Abstract: The main prognostic factors identified in this study were clinical (age and comorbidity) and histological (pathological tumour size, bone invasion and surgical margins).

Cited by 17 publications

References 19 publications

Prognostic value of tumor mutational burden in patients with oral cavity squamous cell carcinoma treated with upfront surgery

Prognostic value of tumor mutational burden in patients with oral cavity squamous cell carcinoma treated with upfront surgery

Nomograms to Predict the Prognosis in Locally Advanced Oral Squamous Cell Carcinoma After Curative Resection

Oral Squamous Cell Carcinoma: Diagnosis and Treatment Planning

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