Clinical and histopathological analysis of specific lesions of cutaneous sarcoidosis in Korean patients

Jung, Ye Jin; Roh, Mi Ryung

doi:10.3109/09546630903440098

Cited by 11 publications

(16 citation statements)

References 19 publications

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“…Tüm dünya-da yaygın olarak görülen bu hastalığın sıklığı, kış ve ilkbahar mevsiminde artış göstermektedir (3,6 Hastalık her iki cinsi tutmakla beraber kadınlardaki sıklığı biraz daha fazladır (1, 4). Yanardağ ve ark.…”

Section: Discussionunclassified

“…En sık görülen özgün sarkoidoz lezyonları makülopapüler lezyonlardır (2,3,5). Ancak son yıllarda yapılan bazı çalışmalarda nodüloplak lezyonların daha sık görüldüğü bildirilmiştir (6,10). Bizim çalışmamızda da nodü-loplak lezyonlar makülopapüler olanlardan daha sık bulundu.…”

Section: Discussionunclassified

“…Ayırıcı tanıda nekrobiyozis lipoidika, lenfomalar, Sweet sendromu ve deri eki tümörleri gibi birçok hastalık yer alır (1,6). Daha önce yapılan çalışmalarda kutanöz sarkoidoz için karakteristik olan çıplak kazeifiye olmayan granülom varlığı bizim çalışmamızda da eritema nodozumu olan hastalar hariç tüm hastalarda gösterilmiştir (6,11,14). Çalışmamızda sarkoidal granülomlar; bir hastada yüzeysel dermis, iki hastada derin dermis, yedi hastada tüm dermis ve dört hastada subkutan dokuda yerleşim göstermekteydi.…”

Section: Discussionunclassified

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A Retrospective Analysis of 15 Patients with Cutaneous Sarcoidosıs

Güler¹,

Demirel²,

Kontaş³

2011

Turk J Dermatol

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ÖzetAmaç: Sarkoidoz, sebebi bilinmeyen, kazeifiye olmayan granülomlarla karakterize multisitemik bir hastalıktır. Bu çalışmadaki amacımız; kutanöz sarkoidozlu hastalarımızın klinikopatolojik özelliklerini ve kutanöz sarkoidoz ile sistemik sarkoidoz arasında-ki ilişkiyi incelemekti. Gereç ve Yöntemler: Erciyes Üniversitesi Tıp Fakültesi, Deri ve Zührevi Hastalıklar Anabilim Dalı'nda 2005-2010 tarihleri arasında kutanöz sarkoidoz tanısı almış 15 hastanın tıbbi kayıtları geriye dönük olarak incelendi. Bulgular: On beş hastanın 12'si kadın, 3'ü erkekti. En sık görülen deri lezyon nodüloplak form (%66.6) idi. Lezyonların en sık yerleştikleri yerler baş-boyun (%40) ve alt ekstremiteler (%40) idi. Tüm hastaların birincil şikayetleri deri belirtileri olmasına rağmen 6 hastada pulmoner tutulum da tespit edildi. Sonuç: Çalışma verileri kutanöz sarkoidozlu hastalarda aynı anda sistemik hastalık bulgularının da eşlik edebileceğini göstermek-tedir. Bu yüzden dermatoloji bölümüne başvuran tüm kutanöz sarkoidozlu hastalarda sistemik tutulumun araştırılması uygun olacaktır. (Turk J Dermatol 2011; 5: 66-70 AbstractObjective: Sarcoidosis is a multisystemic disease characterized by non-caseating granuloma of unknown origin. The purpose of our investigation was to review our patients with cutaneous sarcoidosis in order to evaluate their clinicopathological features and the relationship of cutaneous sarcoidosis with systemic sarcoidosis. Materials and Methods:The medical records of 15 patients diagnosed with cutaneous sarcoidosis at Erciyes University, Dermatology Department between 2005 and 2010 were retrospectively reviewed. Results: Twelve patients were women, 3 patients were men. The most common presentation of cutaneous sarcoidal lesions was the nodulo-plaque form (66.6%) and the most common localization of the lesions were the head-and-neck and the lower extremities in six each (40%, each one). Although all of the patients' primary complaints were cutaneous symptoms, pulmonary involvement was noticed in 6 patients (40%) with cutaneous sarcoidosis. Conclusion:The data of the study suggest that cutaneous sarcoidosis mainly occurs at the onset of the systemic disease. Hence, all patients presenting to the dermatology departments with cutaneous sarcoidal granulomas require investigations for systemic sarcoidosis. (Turk J Dermatol 2011; 5: 66-70)

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Section: Discussionunclassified

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A Retrospective Analysis of 15 Patients with Cutaneous Sarcoidosıs

Güler¹,

Demirel²,

Kontaş³

2011

Turk J Dermatol

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“…Cutaneous sarcoidosis with multisystem involvement is treated with topical steroids or systemic corticosteroids [5]. Asymptomatic patients with isolated lesions may not need systemic corticosteroids and they are followed up [6].…”

Section: Case Report Twomentioning

confidence: 99%

Isolated Cutaneous Sarcoidosis: A New Insight into the Old Entity

Kumar¹

2013

JCDR

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Cutaneous lesions are a part of common manifestation in multi-systemic sarcoidosis and skin involvement occurs in 20% to 35% of the patients with systemic disease. An exclusive cutaneous involvement is rare and it is reported in about 4%-5% of the patients of sarcoidosis. These lesions have been classified into specific and non-specific, depending on the presence of non-caseating granulomas, on histopathologic studies. In the present study, we are reporting two cases of isolated cutaneous sarcoidosis without systemic manifestations, which is a rare presentation. Sarcoidosis will continue to challenge even the most experienced clinicians with respect to a high degree of suspicion and further investigations for diagnosing and treating this disorder. CASE REPORT ONEA 57-years-old male presented with a raised erythematous lesion which measured 1.5x1.5 cm over the forehead. The lesion started as a papule and gradually progressed to the present size. There was no history of dyspnoea, prolonged fever or other systemic complaints. There was no significant family history which included that of tuberculosis. The haematological and biochemical investigations including angiotensin converting enzyme (ACE) levels, ESR, CRP, ANA and serum calcium showed normal values. The ophthalmological assessment was normal. CASE REPORT TWOA 38 year old male presented with a lesion which measured 2 x 1.5 cm over the elbow region, which was provisionally diagnosed as a neurofibroma. The biopsy showed well formed non caseating granulomas with asterioid bodies and Langhans giant cells and a histopathological diagnosis of sarcoidosis was offered. Further evaluation showed no organ involvement and no hilar lymphadenopathy.The patient showed no ocular involvement on ophthalmological assessment and other investigations were normal, including sputum for AFB culture. ACE levels were on higher side of the normal range.are misdiagnosed. The cutaneous lesions of Sarcoidosis assume a vast array of morphologies [2] and they are therefore considered as great mimickers in the dermatology practice. The specific types of lesions are lupus pernio, small and large nodules, small and large plaques and scar infiltrations. Lupus pernio is the most characteristic among the sarcoid skin lesions and it is seen as a chronic, persistent, bluish, indurated plaque with a predilection for nose and cheek, with nasal, mucosal and septal involvements [3].

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“…Sarkoidoz prevalansı, lezyon tipi, şiddeti, ekstrakutanöz tutulum gibi özellikleri ülkelere, farklı etnik gruplar ve cinsiyete göre değişkenlik göstermektedir 3 . Tüm dünyada yaygın olarak görülen bu hastalığın sıklığı, kış ve ilkbahar mevsiminde artış göstermektedir 4 . Tüm sarkoidoz vakalarının yaklaşık %25'inde (%9-37) deri tutulumu gözlenmekte iken hastaların %5,4-13,8'inde sadece deri tutulumu gözlenmektedir 1,5,6 .…”

Section: Introductionunclassified

Kutanöz Sarkoidozlu 27 Hastanın Retrospektif Analizi

Aydoğan¹,

Ozkan-Aydin²,

Tilki³

et al. 2013

Turkderm

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ÖzetAmaç:Sarkoidoz; nedeni bilinmeyen, nonkazeifiye granülomatöz histopatolojisi olan, özellikle akciğer, retiküloendotelyal sistem, göz ve deriyi tutan multisistemik bir hastalıktır. Tüm sarkoidozlu olgularda deri tutulumu %9-37 oranında bildirilirken, sadece deri tutulumu %5,4-13,8 arasındadır. Bu retrospektif çalışmada amaç sarkoidozlu hastalarımızın klinikopatolojik özelliklerini ve kutanöz sarkoidoz ile sistemik sarkoidoz arasındaki ilişkiyi incelemektir.

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Clinical and histopathological analysis of specific lesions of cutaneous sarcoidosis in Korean patients

Abstract: These data reveal the diversity of clinical and histopathologic findings of cutaneous sarcoidosis in Korea.

Cited by 11 publications

References 19 publications

A Retrospective Analysis of 15 Patients with Cutaneous Sarcoidosıs

A Retrospective Analysis of 15 Patients with Cutaneous Sarcoidosıs

Isolated Cutaneous Sarcoidosis: A New Insight into the Old Entity

Kutanöz Sarkoidozlu 27 Hastanın Retrospektif Analizi

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