Clinical and Histopathological Evaluation of MDP/Collagen Induced Arthritis Rat Model (MCIA) after Treatment with Urtica Dioica, Plantago Major and Hypericum Perforatum L Herbal Mixture

Khalifeh, Mohammad; Hananeh, Wael M.; Al-Rukibat, Raida K.; Okour, O; Boumezrag, A

doi:10.1538/expanim.57.101

Cited by 11 publications

(18 citation statements)

References 14 publications

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“…The induction of RA was evaluated clinically by the observation of edema and erythema in the tibia-fibula (knee) and talocrural (ankle) joints 8,9,10. The measurement of edema in the tibia-fibula joint in the flexed position and in the talocrural joint in the neutral position was performed using a digital caliper ( Vonder ) one week after injection of the solution and on the day the animals were euthanized 7,11.…”

Section: Methodsmentioning

confidence: 99%

Effects of inhaled cigarette smoke on the myo-articular system of female rats with collagen-induced arthritis

Moreira

Gomes

Dresch

et al. 2011

Clinics

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Section: Methodsmentioning

confidence: 99%

Effects of inhaled cigarette smoke on the myo-articular system of female rats with collagen-induced arthritis

Moreira

Gomes

Dresch

et al. 2011

Clinics

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“…The Phytochemical analysis of U.dioica showed it contain (alkaloid, flavonoid, terpenoid, tannin, phenolic and several of minerals elements) which has hepatoprotective activity through its free radical scavenger. 14,43,44 The previous study has suggested that regucalcin can directly bind and stimulate Ca +2 pump activity. 45,46 Therefore, the phenolic compound of U.dioica may play an important role in decreasing Ca +2 pumping activity and maintain both cell homoeostasis and function that led to decrease regucalcin level [47][48][49] .…”

Section: Study Of the Effect Of Udioica On Regucalcin Levelmentioning

confidence: 99%

Assessment of Hepatoprotective Role of Phenolic Extract of Urtica Dioica and Silver Nanoparticles in Male Rat Induced by Carbon Tetra-Chloride

Kadhim¹,

Aldujaili²,

Homady³

2017

Rasayan J Chem

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This study showed the protective role of the phenolic extract of Urtica dioica and silver nanoparticles (AgNPS) on the hepatotoxicity effect via carbon tetrachloride (CCL4) within white male rats. Hundred and ten male albino rats weighing (200-250g) and aged (10-17week). Animals were housed in the animal house of faculty of Science/University of Kufa under control condition; light 12 and 12 dark hours and temperature (24±2C°).Animals divided into four groups as follows the control groups, carbon tetrachloride groups, phenolic extract groups, and silver nanoparticles, groups. Subdivided groups above depending on the concentration (250 and 500mg/kg) of phenolic extract, (10 and 5mg/kg) of silver nanoparticles for (two and three) month add to dosage after and before induced by carbon tetrachloride (five animals per group).The current study revealed the occurrence of a significant decrease (P≤0.05) in the level of regucalcin when the administered by phenolic extract and silver nanoparticles for (two and three months) compared with carbon tetrachloride group. Highly significant (p≤0.05) with the concentration of the (500mg/kg) for phenolic extract and (10mg/kg) for silver nanoparticles, and no significant observed between extract and silver nanoparticles for (two and three months) and before and after induced by the carbon tetrachloride.

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“…Each rat was immunized with 0.1 ml of the cold emulsion (0.1 mg CII) using a Hamilton glass syringe by subcutaneous injection into the base of the tail, 2-3 cm from the body on day 0. Rats were boosted subcutaneously by a second injection of 0.1 ml (0.1 mg CII) of the collagen emulsion also into the base of the tail 7 days after the first immunization [18,19].…”

Section: Induction Of Type II Collagen-induced Arthritismentioning

confidence: 99%

“…The arthritis score for each mouse was the sum of all paw scores where the highest score per mouse would be 16 [19].…”

Section: Clinical Assessment Of Arthritismentioning

confidence: 99%

“…Histopathological change in tarsal joints was scored using the following parameters: 0 = normal; 1 = mild inflammatory cell infiltration of synovium; 2 = moderately severe inflammatory cell infiltration with early cartilage loss; and 3 = severe inflammation with pannus formation, marked cartilage loss, and\or periarticular bone erosions. Three histological sections were reviewed for each of the right and left hind paws of each rat and a mean histopathologic severity score derived for the six histologic sections in each animal [19][20][21].…”

Section: Histopathological Examinationmentioning

confidence: 99%

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Protective effect of soy protein on collagen-induced arthritis in rat

et al. 2011

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To evaluate preventive and therapeutic effects of soy protein on collagen-induced arthritis rats. Sprague-Dawley rats immunized with bovine type II collagen emulsified in adjuvant and treated with soy protein (7 g/kg), dexamethasone (1 mg/kg), and casein (in control groups) by daily gavages feedings for 30 days. Score of arthritis recorded every day for each paws of animal. Tumor necrosis factor-alpha, interleukin6, leptin, and adiponectin were measured in serums. Treatment with soy protein resulted in significant delay in time to onset of arthritis as well as significantly decreased arthritis incidence, clinical arthritis severity score, histopathological arthritis severity score, and in vivo cell-mediated immunity to collagen (P < 0.05). Administration of soy protein significantly suppressed the progression of collagen II-induced arthritis and inhibited the production of tumor necrosis factor-alpha, interleukin6, leptin, and adiponectin. Soy protein appeared to be a potent immunomodulatory inhibitor of collagen II-induced arthritis in rats. It could delay onset of RA and reduced cartilage erosion and synovitis inflammation. Therefore, it may be a useful protein in the prevention and treatment of rheumatoid arthritis patient.

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Clinical and Histopathological Evaluation of MDP/Collagen Induced Arthritis Rat Model (MCIA) after Treatment with Urtica Dioica, Plantago Major and Hypericum Perforatum L Herbal Mixture

Abstract: This study was done to assess the effects of Urtica dioica, Plantago major and

Cited by 11 publications

References 14 publications

Effects of inhaled cigarette smoke on the myo-articular system of female rats with collagen-induced arthritis

Effects of inhaled cigarette smoke on the myo-articular system of female rats with collagen-induced arthritis

Assessment of Hepatoprotective Role of Phenolic Extract of Urtica Dioica and Silver Nanoparticles in Male Rat Induced by Carbon Tetra-Chloride

Protective effect of soy protein on collagen-induced arthritis in rat

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