Protective effect of soy protein on collagen-induced arthritis in rat

Abstract

To evaluate preventive and therapeutic effects of soy protein on collagen-induced arthritis rats. Sprague-Dawley rats immunized with bovine type II collagen emulsified in adjuvant and treated with soy protein (7 g/kg), dexamethasone (1 mg/kg), and casein (in control groups) by daily gavages feedings for 30 days. Score of arthritis recorded every day for each paws of animal. Tumor necrosis factor-alpha, interleukin6, leptin, and adiponectin were measured in serums. Treatment with soy protein resulted in significant delay in time to onset of arthritis as well as significantly decreased arthritis incidence, clinical arthritis severity score, histopathological arthritis severity score, and in vivo cell-mediated immunity to collagen (P < 0.05). Administration of soy protein significantly suppressed the progression of collagen II-induced arthritis and inhibited the production of tumor necrosis factor-alpha, interleukin6, leptin, and adiponectin. Soy protein appeared to be a potent immunomodulatory inhibitor of collagen II-induced arthritis in rats. It could delay onset of RA and reduced cartilage erosion and synovitis inflammation. Therefore, it may be a useful protein in the prevention and treatment of rheumatoid arthritis patient.

Food-Derived Bioactive Peptides on Inflammation and Oxidative Stress

“…Feeding of soy protein isolate to rodents (which presumably generates bioactive short peptides through intestinal digestion) has shown beneficial effects on experimentally induced arthritis [53] and genetically predisposed atherosclerosis [54], through the induction of protective anti-inflammatory effects. Soybean peptides such as VPY and others have shown promise in controlling cytokine/chemokines levels, reduction of oxidative stress, and reversal of the tissue damage observed in animal models of colitis, suggesting potential applications in treatment of inflammatory bowel diseases [55, 56].…”

Therapeutic antioxidant and anti-inflammatory effects of laser acupuncture on patients with rheumatoid arthritis

“…RA is a chronic inflammation disease characterized by persistent joint synovitis, proliferation of the synovial cells, and destruction of the cartilage and bone in a symmetrical distribution . Multiple factors as mentioned before in the introduction are involved in the development of disease.…”

Contribution of Dietary Factors to Peroxisome Proliferator-Activated Receptor-Mediated Inflammatory Signaling in Arthritic Diseases

“…Optimization of the isoflavone content in soy protein should therefore be considered before it is used as a therapeutic agent-e.g., for metabolic syndrome [44,47]. A recent report by Mohammad Shahi et al [48] has demonstrated that the administration of soy protein to Sprague-Dawley rats protects them from collagen-induced arthritis (CIA), an animal model of human rheumatoid arthritis (RA).…”