Clinical and Histopathological Investigation of Seborrheic Keratosis

Roh, Nam Kyung; Hahn, Hyung Jin; Lee, Yang Won; Choe, Yong Beom; Ahn, Kyu Joong

doi:10.5021/ad.2016.28.2.152

Cited by 56 publications

(77 citation statements)

References 15 publications

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“…In addition to this classic appearance, SK can present many morphological “faces”; in fact, some SKs may be quite difficult to clinically distinguish from other diagnostic entities, such as squamous cell carcinoma, melanocytic nevi, or even malignant melanomas [3,4]. On histopathology, SK can be divided into six principle variants: acanthotic, hyperkeratotic, adenoid, irritated, clonal and melanoacanthoma [5]. …”

Section: Discussionmentioning

confidence: 99%

In vivo reflectance confocal microscopy features of a melanoacanthoma

Shahriari

Grant‐Kels

Rabinovitz

et al. 2016

Dermatol Pract Concept

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Efforts have been expended to evaluate the reflectance confocal microscopy (RCM) features of different clinical entities in order to more thoroughly delineate benign versus malignant features. In this way, RCM can help clinicians to be more selective in regard to undertaking appropriate skin biopsies and improving their benign to malignant ratio. Herein, we report a case of a histopathologically proven melanoacanthoma, a variant of seborrheic keratosis. There are scarce reports describing the RCM features of melanoacanthoma. Our case demonstrated RCM features that were suspicious for melanoma. More RCM images of this benign entity are needed to establish definitive diagnostic criteria.

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Section: Discussionmentioning

confidence: 99%

In vivo reflectance confocal microscopy features of a melanoacanthoma

Shahriari

Grant‐Kels

Rabinovitz

et al. 2016

Dermatol Pract Concept

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“…A fim de simplificar a denominação para essa condição, o termo melanoacantoma foi introduzido como um correspondente ao melanoepitelioma tipo I [6]. E mais recentemente, o melanoepitelioma tipo II foi denominado por alguns autores como uma queratose seborreica melanocítica [8,9]; no entanto, outros autores acreditam que os dois tumores são a mesma entidade e, por isso, devem ser unificadas pelo termo melanoacantoma [11]. Diferentemente, em medicina veterinária, não há distinção em tipos, utilizando-se inicialmente o termo melanocitoma-acantoma para denominar a proliferação histologicamente similar à lesão observada em humanos [2,5,7], e mais recentemente, melanoacantoma, similar à nomenclatura médica humana [3,10].…”

Section: Casounclassified

Melanocytoma-acanthoma in a Dog

Mazaro

Lorensetti

Herbichi

et al. 2019

Acta Scientiae. Vet.

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Background: Melanocytic neoplasms are skin tumors that often occur in dogs. However, melanocytoma-acanthoma, also called melanoacanthoma, is a benign melanocytic neoplasm rarely reported in this species, which has been described only three times in the veterinary literature. Briefly, this tumor is characterized by a single, painless, darkly pigmented and firm cutaneous papule or nodule. Histologically, it is composed of mixed populations of well-differentiated melanocytes and keratinocytes, unlike traditional melanocytic tumors (melanoma and melanocytoma). These cells are arranged in lobules surrounded by collagenous stroma. Melanocytes are large epithelioid cells containing varying amounts of melanin. Keratinocytes form anastomosing trabeculae with peripheral palisading, and small cysts containing amorphous or laminated keratin. The definitive diagnosis of melanocytoma-acanthoma is based on histopathological findings. This report describes a case of melanocytoma-acanthoma in a dog in Brazil. Case: A 9-year-old female miniature Schnauzer dog was examined at the Veterinary Hospital of the Federal University of Santa Maria, where a single, firm, pigmented papule was found in the auricle. The lesion had started 15 days earlier.Hematological tests and serum biochemistry profile were normal. An excisional biopsy of the papule was surgically removed and subjected to histopathological examination. The tissue was fixed in 10% neutral buffered formalin, processed routinely and embedded in paraffin wax. Sections were stained with hematoxylin and eosin (HE). A histopathological examination revealed a nonencapsulated, well-defined, extensive, densely cellular proliferation located in dermis. This proliferation was composed of lobules and nests of well-differentiated stratified squamous epithelium closely associated with neoplastic melanocytes, surrounded by thin bundles of fibrous stroma. A diagnosis of melanocytoma-acanthoma was established based on these histological features. Discussion: The first description of melanocytoma-acanthoma in humans was as melano-epithelioma, classified into subtypes I and II. Both subtypes are benign neoplasms composed of well-differentiated melanocytes and keratinocytes, which are distinguished from one another based on the amount and distribution of melanocytes. Type I melano-epithelioma is characterized by proliferative lobules of melanocytes and keratinocytes, including melanocytes scattered diffusely among keratinocytes. Type II melano-epithelioma involves only the proliferation of keratinocytes, while melanocytes are limited to the basal layer of keratinocyte lobules. To clarify this condition, some authors use the term "melanoacanthoma" to indicate the above-described type I melano-epithelioma, and seborrheic keratosis to indicate type II melano-epithelioma. However, other authors use the term melanoacanthoma to denote the two conditions (types I and II melano-epithelioma). On the other hand, veterinary medicine does not recognize subtypes, instead using the term melanocytoma-acanthoma...

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“…Although there is no strict consensus about the different subtypes of SK, most authors recognize the following: acanthotic (the most frequent), hyperkeratotic, adenoid, reticulated, clonal, irritated and melanoacanthoma. 1 In addition to the those classical histological forms, Neuhaus et al 2 described in 2006, 9 cases of SK with clear cells in their basal layer, mimicking the appearance of a SK overrun by a melanoma in situ. Here, we present a new case of SK with this peculiar characteristic and illustrate the immunoperoxidase features that allowed a proper diagnosis.…”

Section: Seborrheic Keratosis With Basal Clear Cells: Report Of a Casmentioning

confidence: 99%

“…Epidermolysis bullosa acquisita (EBA) is a rare autoimmune bullous disease (AIBD) induced by circulating immunoglobulin (Ig) G autoantibodies to type VII collagen that cause subepidermal blisters. 1 The most prevalent manifestation of coexisting AIBD and psoriasis is bullous pemphigoid, but EBA with psoriasis has been rarely reported. 2,3 The mechanism underlying the coexistence of AIBD and psoriasis has not been elucidated.…”

Section: Psoriasis Is a Chronic T-cell-mediated Inflammatory Diseasementioning

confidence: 99%