“…1,10,11 ONFH is a devastating and progressive disease, which, if left untreated, will cause the collapse of the femoral head. 12,13 Consequently, approximately 70% of patients need hip replacement. 14- 16 While existing theories have pointed to the roles of intravascular coagulation and fat embolism as well as extravascular fat accumulation-mediated vascular constriction in the pathogenesis of ONFH, 17 the exact mechanism is still largely unknown.…”